Wettability and surface chemistry of crystalline and amorphous forms of a poorly water soluble drug

Investigation of Atypical Dissolution Behavior of an Encapsulated Amorphous Solid Dispersion

“…A lower shift observed in case of ACSD, suggested that the PVP hydrophilic sites were less accessible to water and it was partially interacting with both A-CLB and water molecules to form an interlinked structure. The greater polar surface free energy of A-CLB compared with its crystalline counterpart 24 can also promote this phenomenon. Conversely, in PM-ACSD and CCSD, the drug remained relatively noninteracted, which allowed PVP to hydrogen bond with water and display greater mobility.…”

Experimental and Computational Methods Pertaining to Surface Tension of Pharmaceuticals

“…Contact angle is one of the most widely used techniques in the surface characterization and wettability of pharmaceuticals formulations. The sessile drop technique is commonly used for estimating contact angle of pharmaceutical powders (Buckton, 1993), drug-carrier adhesion (Podczeck et al, 1996), compaction and granulation (Puri et al, 2010), emulsion stability (Hansen and Fagerheim, 1998), human biological fluids (Noordman et al, 1999) and dynamic wettability properties of contact lens hydrogels (Ketelson et al, 2005).…”

“…In order to meet challenges and develop new and better performing pharmaceutical products, knowledge of surface tension and its measurements techniques is of utmost importance. Amongst many techniques used for characterizing the surface energies of pharmaceuticals are the surface tension measurements, contact angle and wettability tests (Buckton, 1988;Chamarthy et al, 2009;Puri et al, 2010). The objective of this chapter is to introduce experimental and computational methods of surface tension measurment in the pharmaceutical industry.…”

A Review on Encapsulation of Oils

“…It has been proved that powders in crystalline state have lower interaction with water, while amorphous solids contain polar energetic sites having hydrogen bonding capacity with water molecules [60]. In a study dealing with encapsulation of annatto seed oil with whey protein isolate or modified starch by spray drying or freeze drying techniques, it was reported that all microparticles, independent from the type of wall material and drying method used, exhibited amorphous state [61].…”