What are the roles of macrophages and monocytes in human pregnancy?

Tang, Manshu; Hu, Xiaohui; Liu, Zhaozhao; Kwak‐Kim, Joanne; Liao, Aihua

doi:10.1016/j.jri.2015.08.001

Cited by 72 publications

(59 citation statements)

References 73 publications

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“…Innate immune system: Several authors have suggested that the maternal innate immune system may be more active in pregnancy to compensate for a possible repression of adaptive immune system and that this overactivity may be responsible for pregnancy complications including PTL and preeclampsia [34]. We studied the response to LPS measuring the circulating cytokines and although there was a marked increase in the most cytokines/chemokines in both pregnant and NP mice, only the response of the anti-inflammatory cytokine, IL-4, was greater in pregnant mice.…”

Section: Discussionmentioning

confidence: 99%

The response of the innate immune and cardiovascular systems to LPS in pregnant and nonpregnant mice†

Zöllner

Howe

Edey

et al. 2017

Biology of Reproduction

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Sepsis is the leading cause of direct maternal mortality, but there are no data directly comparing the response to sepsis in pregnant and nonpregnant (NP) individuals. This study uses a mouse model of sepsis to test the hypothesis that the cardiovascular response to sepsis is more marked during pregnancy. Female CD1 mice had radiotelemetry probes implanted and were time mated. NP and day 16 pregnant CD-1 mice received intraperitoneal lipopolysaccharide (LPS; 10 μg, serotype 0111: B4). In a separate study, tissue and serum (for RNA, protein and flow cytometry studies), aorta and uterine vessels (for wire myography) were collected after LPS or vehicle control administration. Administration of LPS resulted in a greater fall in blood pressure in pregnant mice compared to NP mice. This occurred with similar changes in the circulating levels of cytokines, vasoactive factors, and circulating leukocytes, but with a greater monocyte and lesser neutrophil margination in the lungs of pregnant mice. Baseline markers of cardiac dysfunction and apoptosis as well as cytokine expression were higher in pregnant mice, but the response to LPS was similar in both groups as was the ex vivo assessment of vascular function. In pregnant mice, nonfatal sepsis is associated with a more marked hypotensive response but not a greater immune response. We conclude that endotoxemia induces a more marked hypotensive response in pregnant compared to NP mice. These changes were not associated with a more marked systemic inflammatory response in pregnant mice, although monocyte lung margination was greater. The more marked hypotensive response to LPS may explain the greater vulnerability to some infections exhibited by pregnant women. Pregnancy enhances LPS-induced hypotension, 2017, Vol. 97, No. 2 Summary SentenceIn pregnant mice, nonfatal sepsis is associated with a more marked hypotensive response but not a greater immune response.

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Section: Discussionmentioning

confidence: 99%

The response of the innate immune and cardiovascular systems to LPS in pregnant and nonpregnant mice†

Zöllner

Howe

Edey

et al. 2017

Biology of Reproduction

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“…The changes in the innate immune system during pregnancy are characterised by increased numbers of circulating monocytes and granulocytes, resulting in a higher number of total leukocytes (Tang et al 2015). Peripheral monocyte numbers are higher, mainly due to …”

Section: Maternal Circulationmentioning

confidence: 99%

“…These monocytes are pro-inflammatory, producing IL-1β, IL-6 and TNF-α (Tang et al 2015) ( Table 1) and are recruited into gestational tissues, especially the decidua, during labour (Tang et al 2015). Peripheral circulating leukocytes have also been noted to display early chemotactic responsiveness during late gestation, which would aid their infiltration into uterine tissues (Gomez-Lopez et al 2013).…”

Section: :3mentioning

confidence: 99%

“…The placenta is a site of peripheral monocytic activation, where monocytes encounter the villous trophoblast (Tang et al 2015). Studies of placental cells and tissue in vitro have demonstrated their ability to respond to inflammatory stimuli such as pathogenic bacteria, LPS or IL-1 with increased production of cytokines (IL-1, IL-6, IL-10), chemokines (macrophage chemotactic protein-1 (MCP-1), IL-8) and prostanoids (Denison et al 1998, Goodwin et al 1998, Gniesinger et al 2001.…”

Section: Choriodecidua (Cd)mentioning

confidence: 99%

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Myometrial cytokines and their role in the onset of labour

Sivarajasingam

Imami

Johnson

2016

Journal of Endocrinology

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Human labour is an inflammatory event, physiologically driven by an interaction between hormonal and mechanical factors and pathologically associated with infection, bleeding and excessive uterine stretch. The initiation and communicators of inflammation is still not completely understood; however, a key role for cytokines has been implicated. We summarise the current understanding of the nature and role of cytokines, chemokines and hormones and their involvement in signalling within the myometrium particularly during labour.

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“…Dysregulation of the interaction among macrophage, NK and T-cells may lead to PE [31][32][33]. According to study of Lockwood et al excess macrophage-derived TNF-a production interferes with normal stepwise spiral artery remodelling and leading to PE.…”

Section: Discussionmentioning

confidence: 99%

Are There Any Differences Between the Distribution of Placental Bed Leukocyte Subtypes and Plasma Cytokine Levels of Preeclamptic and Healthy Pregnants?

Özkan

Devici

Şi̇mşek

et al. 2017

Journal of Advanced Medical Sciences and Applied Technologies

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Objectives: Preeclampsia (PE) is associated with impaired decidual leukocyte and plasma cytokine balance compared with normal pregnancy. We aimed to investigate maternal plasma levels of Interferon-gamma (IFN-g), Tumor Necrosis Factor-alpha (TNF-a), Transforming Growth Factor-beta (TGF-b), Interleukin-4 (IL4), IL6, IL10, IL17, IL35, suppressor of Cytokine Signalling-3 (SOCS3) and placental bed leukocytes in preeclamptic and healthy pregnants. Materials & Methods:This study was conducted with 40 preeclamptic and 40 normotensive pregnants. Cytokine levels were studied with enzyme-linked immunosorbent assay. CD8, CD56 and CD163 antigens were analysed by immunohistochemical study on placental bed biopsies. Results:In preeclamptic women; IFN-g and TGF-b levels were significantly higher and IL-35 levels were significantly lower than those of controls. CD8, CD56 and CD163 positivity of preeclamptic group were not significantly higher than those of controls. CD8 staining showed negative correlation with plasma IL17 levels. CD163 staining showed negative correlation with TNF-a/IL4 ratio. TNF-a/IL4 ratio showed minimal influence on placental bed CD163 staining. Conclusion:Slightly increased placental bed CD8, CD56 and CD163 positive leukocytes and increased plasma IFN-g, TGF-b and decreased plasma IL35 levels of preeclamptic pregnants indicate an aberrant cell mediated immunity in PE. We could not say yet that this condition is whether result or reason. New studies are needed to discuss our results.

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What are the roles of macrophages and monocytes in human pregnancy?

Cited by 72 publications

References 73 publications

The response of the innate immune and cardiovascular systems to LPS in pregnant and nonpregnant mice†

The response of the innate immune and cardiovascular systems to LPS in pregnant and nonpregnant mice†

Myometrial cytokines and their role in the onset of labour

Are There Any Differences Between the Distribution of Placental Bed Leukocyte Subtypes and Plasma Cytokine Levels of Preeclamptic and Healthy Pregnants?

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