What causes the onset of psychosis?

Broome, Matthew R.; Woolley, James B.; Tabraham, Paul; Johns, Louise; Bramon, Elvira; Murray, Graham; Pariante, Carmine M.; McGuire, Philip; Murray, Robin M.

doi:10.1016/j.schres.2005.02.007

Cited by 163 publications

(121 citation statements)

References 86 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…Anhedonia has been hypothesized to be a core feature of schizophrenia [349-351], and it has been suggested that individuals with high levels of social anhedonia are more likely to develop schizophrenia-spectrum disorders [352], although the link between anhedonia and the so-called schizophrenia prodrome has not been firmly established [353]. The centrality of incentive motivation deficits to schizophrenia is suggested by the long-standing hypotheses regarding the role of DA disturbances in the pathophysiology of the disorder [354-356].…”

Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

View full text Add to dashboard Cite

This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate disorders to disease classification is discussed, followed by a review of the neurobiology of reward circuitry. We next consider preclinical animal models and clinical evidence of reward-pathway dysfunction in a range of disorders, including psychiatric disorders (i.e., substance-use disorders, affective disorders, eating disorders, and obsessive compulsive disorders), neurodevelopmental disorders (i.e., schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorders, Tourette’s syndrome, conduct disorder/oppositional defiant disorder), and genetic syndromes (i.e., Fragile X syndrome, Prader–Willi syndrome, Williams syndrome, Angelman syndrome, and Rett syndrome). We also provide brief overviews of effective psychopharmacologic agents that have an effect on the dopamine system in these disorders. This review concludes with methodological considerations for future research designed to more clearly probe reward-circuitry dysfunction, with the ultimate goal of improved intervention strategies.

show abstract

Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

View full text Add to dashboard Cite

show abstract

“…32 The diagnosis was based on assessment by 2 experienced clinicians using the Comprehensive Assessment for the ARMS (CAARMS) 33 and a consensus meeting with the clinical team. An individual can meet criteria for ARMS in 1 or more of 3 ways: 1) a recent decline in function coupled with either schizotypal personality disorder or a first-degree relative with psychosis, 2) attenuated positive symptoms and 3) a brief psychotic episode of less than 1 week's duration that resolves without antipsychotic medication.…”

Section: Participantsmentioning

confidence: 99%

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

Fusar‐Poli

Crossley

Woolley

et al. 2011

jpn

Self Cite

View full text Add to dashboard Cite

“…23 The diagnosis was based on assessment by two experienced clinicians using the Comprehensive Assessment for the ARMS (CAARMS), 8 and a consensus meeting with the clinical team. All subjects were antipsychotic naive at the time of the fMRI scanning.…”

Section: Subjectsmentioning

confidence: 99%

Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis

et al. 2009

View full text Add to dashboard Cite

What causes the onset of psychosis?

Cited by 163 publications

References 86 publications

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis

Contact Info

Product

Resources

About