What do I need to know about penicillin antibiotics?

Barker, Charlotte I. S.; Germovsek, Eva

doi:10.1136/archdischild-2015-309068

Cited by 11 publications

(4 citation statements)

References 15 publications

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“…In clinic, the most commonly used antimicrobial agents are antibiotics, which include natural antibiotics and synthetic antibiotics. Penicillin is a typical natural antibiotic which is produced by fungal metabolism[1]. Synthetic antibiotics, such as quinolones, are the most common type of antibiotics today and play important roles in the treatment of clinical diseases[2].…”

Section: Introductionmentioning

confidence: 99%

Effects of various antimicrobial agents on multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells

Li¹,

Yue²

2019

WJSC

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Antimicrobial drugs of several classes play an important role in the treatment of bone and joint infections. In addition to fighting pathogenic microorganisms, the effects of drugs on local tissues and cells are also related to the course and prognosis of bone and joint infections. The multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells (MSCs) is essential for tissue repair after local injury, which is directly related to the recovery of bone, cartilage, and medullary adipose tissue. Our previous studies and the literature indicate that certain antimicrobial agents can regulate the differentiation potential of bone marrow-derived MSCs. Here, in order to systematically analyze the effects of various antimicrobial drugs on local tissue regeneration, we comprehensively review the studies on the effects of these drugs on MSC differentiation, and classify them according to the three differentiation directions (osteogenesis, chondrogenesis, and adipogenesis). Our review demonstrates the specific effects of different antimicrobial agents on bone marrow-derived MSCs and the range of concentrations at which they work, and provides a basis for drug selection at different sites of infection.

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Section: Introductionmentioning

confidence: 99%

Effects of various antimicrobial agents on multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells

Li¹,

Yue²

2019

WJSC

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“…Additionally, penicillin−V was also identified as a significant metabolite, exhibiting a high VIP score and average importance. While penicillin antibiotics are known for their safety and low toxicity in neonates, the severity of the use of empirical antibiotics in preterm infants has also been reported [27,28]. The detection of these drugs in high concentrations in urine and systemic circulation suggests a significant association between material transfer between preterm infants and mothers.…”

Section: Investigating the Diverse Physiological Mechanisms And Drug ...mentioning

confidence: 99%

Biochemical Profiling of Urine Metabolome in Premature Infants Based on LC−MS Considering Maternal Influence

Mok,

Song,

Hahn

et al. 2024

Nutrients

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In this study, Liquid Chromatography–Mass Spectrometry (LC-MS)-based metabolomics profiling was conducted to elucidate the urinary profiles of premature infants during early and late postnatal stages. As a result, we discovered significant excretion of maternal drugs in early−stage infants and identified crucial metabolites like hormones and amino acids. These findings shed light on the maternal impact on neonatal metabolism and underscore the beneficial effects of breastfeeding on the metabolism of essential amino acids in infants. This research not only enhances our understanding of maternal–infant nutritional interactions and their long−term implications for preterm infants but also offers critical insights into the biochemical characteristics and physiological mechanisms of preterm infants, laying a groundwork for future clinical studies focused on neonatal development and health.

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“…Penicillin, such as amoxicillin, is one of the most prescribed antibiotics due to its effectiveness in managing a wide range of common infections, cost-friendly and availability (Barker et al, 2017). Penicillin consists of the lactam ring, which is joined to a five-membered ring containing a thioether group as well as an amine group located in the positions first and fourth, respectively (Hoemann, 2012).…”

Section: Literature Reviewmentioning

confidence: 99%

Stability studies of reconstituted oral amoxicillin suspension (125mg/5ml) under different temperature storage conditions

Obat

Kipsang

Maru

2022

Editon Cons. j. res. med. health sci.

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The research objective was to determine the physical stability and concentration of amoxicillin reconstituted oral suspension (125mg/5ml) stored under room temperature of 25°C and refrigeration temperature of 2-8°C days 1, 3, and 7. Three different brands of amoxicillin samples were used. Samples from the reconstituted amoxicillin suspension was assayed by HPLC to determine the concentration of the active and examined physically for taste, odour and colour change. The drug concentration for all three brands during the seven days ranged from 88.94 per cent - 102.17 per cent for refrigerated and 89.57-99.7 per cent for reconstituted amoxicillin at room temperature. The odour for days 1, 3 and 7 is fruity. The colour was pale yellow for days 1 and 3, while on day 7, it was creamy yellow. The taste was sweet on days 1 and 3, while on day 7, it was sweet/low bitter. The three brands maintained their potency and physical stability as required in the British pharmacopoeia. The reconstituted antibiotic suspensions must be stored at room temperature or in a refrigerator to maintain potency throughout their use. However, a good number of patients do not adhere to storage specifications resulting in the degradation of the product and subsequent loss of potency. The results for day one for all the drugs fall within the accepted range, drug K has its percent concentration the lowest, and microbiological studies should be done on this drug to ascertain microbial stability.

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What do I need to know about penicillin antibiotics?

Cited by 11 publications

References 15 publications

Effects of various antimicrobial agents on multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells

Effects of various antimicrobial agents on multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells

Biochemical Profiling of Urine Metabolome in Premature Infants Based on LC−MS Considering Maternal Influence

Stability studies of reconstituted oral amoxicillin suspension (125mg/5ml) under different temperature storage conditions

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