What do we know about self-reported fatigue in systemic lupus erythematosus?

Cleanthous, Sophie; Tyagi, Manavi; Isenberg, David; Newman, Stanton

doi:10.1177/0961203312436863

Cited by 81 publications

(63 citation statements)

References 65 publications

(197 reference statements)

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“…Fatigue improved by an approximate average of 4 points (post-intervention) and 3 points (four months post-intervention) in intervention participants, which is greater than the minimum clinically significant change suggested for interpreting change scores in lupus trials[46–47]. It is notable that while the mean fatigue score for intervention participants decreased post-intervention, the mean fatigue score for control participants actually increased.…”

Section: Discussionmentioning

confidence: 81%

An intervention to reduce psychosocial and biological indicators of stress in African American lupus patients: The balancing lupus experiences with stress strategies study

Williams¹,

Penfield²,

Kamen³

et al. 2014

OJPM

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Objective Very little is known about the impact of psychosocial stress on African American lupus patients. Due to the exposure of African Americans to a unique trajectory of stressors throughout life, it may be critical to understand the relationship between psychosocial stress and underlying biological mechanisms that influence disease activity and pathology in this high risk group. Methods The Balancing Lupus Experiences with Stress Strategies (BLESS) study piloted the validated “Better Choices, Better Health” Chronic Disease Self-Management Program (CDSMP) in 30 African-American lupus patients participating in the SLE Clinic Database Project at the Medical University of South Carolina (MUSC). Measures of psychosocial and biological indicators of stress were collected in all of the patients in each of the study conditions before and after intervention activities, as well as four months post-intervention, to assess the effectiveness of the program in reducing perceived and biological indicators of stress. Results Participation in the workshops had large effects upon depression (d=1.63 and d = 1.68), social/role activities limitations (d =1.15), health distress (d =1.13 and d = 0.78), fatigue (d =1.03), pain (d =0.96), and lupus self-efficacy (d =0.85). Neither the differences in cortisol or DHEA levels pre- and post-intervention were found to be significantly different between intervention participants and controls. Conclusion The intervention workshops acted to reduce perceived stress and improve quality of life. Our findings imply that comparable, if not more significant gains in relevant health indicators are possible in African American patients when provided the opportunity to participate in CDSMP’s.

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Section: Discussionmentioning

confidence: 81%

An intervention to reduce psychosocial and biological indicators of stress in African American lupus patients: The balancing lupus experiences with stress strategies study

Williams¹,

Penfield²,

Kamen³

et al. 2014

OJPM

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“…Fatigue accompanies inflammation and is frequently reported among patients with a wide range of chronic inflammatory conditions. The prevalence of fatigue in patients with RA, defined as a score of > 20 on the fatigue visual analogue scale, was reported to be 41% in one study, and fatigue is among the most commonly reported phenomena in multiple sclerosis, pSS and SLE . In inflammatory diseases, as well as in cancer‐related fatigue, the fatigue has sometimes been related to altered or increased proinflammatory cytokine production .…”

Section: Fatigue In Chronic Diseasesmentioning

confidence: 99%

“…The prevalence of fatigue in patients with RA, defined as a score of > 20 on the fatigue visual analogue scale, was reported to be 41% in one study, 66 and fatigue is among the most commonly reported phenomena in multiple sclerosis, pSS and SLE. [67][68][69][70] In inflammatory diseases, as well as in cancer-related fatigue, the fatigue has sometimes been related to altered or increased proinflammatory cytokine production. 71,72 However, in general there seems to be a poor correlation between disease activity and the severity of fatigue.…”

Section: Fatigue In Chronic Diseasesmentioning

confidence: 99%

Fatigue in psoriasis: a phenomenon to be explored

et al. 2015

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Summary Fatigue is a prevalent and substantial phenomenon in many patients with chronic inflammatory diseases, often rated by patients as the most troublesome symptom and aspect of their disease. It frequently interferes with physical and social functions and may lead to social withdrawal, long‐standing sick leave and disability. Although psychological and somatic factors such as depression, sleep disorders, pain and anaemia influence fatigue, the underlying pathophysiological mechanisms by which fatigue is generated and regulated are largely unknown. Increasing evidence points towards a genetic and molecular basis for fatigue as part of the innate immune system and cellular stress responses. Few studies have focused on fatigue in dermatological diseases. Most of these studies describe fatigue as a phenomenon related to psoriatic arthritis and describe the beneficial effects of biological agents on fatigue observed in clinical studies. It is therefore possible that this problem has been underestimated and deserves more attention in the dermatological community. In this review, we provide a definition and explanation for chronic fatigue, describe some commonly used instruments for measuring fatigue, and present hypothetical biological mechanisms with an emphasis on activation of the innate immune system and oxidative stress. An overview of relevant clinical studies covering the theme ‘psoriasis and fatigue’ is given.

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“…25 It is not included in the ACR criteria but it can significantly affect behavior and function, 26 is extremely common in SLE, and often does not respond to traditional SLE treatments. 27 In this respect, quality-of-life questionnaires usually include fatigue, so although they should not replace more comprehensive neurologic and psychological instruments, they are useful to include in the diagnostic repertoire.…”

Section: Symptoms Of Npslementioning

confidence: 99%

Neuropsychiatric Symptoms in Lupus

Gulinello¹,

Wen²,

Putterman³

2012

Psychiatric Annals

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CME Educational Objectives 1. Learn the symptoms, diagnostic procedures, and prevalence of neuropsychiatric lupus (NPSLE). 2. Understand the current hypotheses regarding the putative mechanisms underlying NPSLE. 3. Become familiar with some of the current strategies for treatment of NPSLE and understand their limitations. The neuropsychiatric aspects of systemic lupus erythematosus have been less studied than the peripheral aspects of the disease, and the importance of neuropsychiatric symptoms has been underestimated. Furthermore, until recently, the diagnostic criteria were not standardized and were not sufficiently based on systematic evidence from preclinical and clinical data.

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What do we know about self-reported fatigue in systemic lupus erythematosus?

Cited by 81 publications

References 65 publications

An intervention to reduce psychosocial and biological indicators of stress in African American lupus patients: The balancing lupus experiences with stress strategies study

An intervention to reduce psychosocial and biological indicators of stress in African American lupus patients: The balancing lupus experiences with stress strategies study

Fatigue in psoriasis: a phenomenon to be explored

Neuropsychiatric Symptoms in Lupus

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