2017
DOI: 10.1136/archdischild-2017-313538
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What dose of aspirin should be used in the initial treatment of Kawasaki disease?

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Cited by 12 publications
(9 citation statements)
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“…However, effect of aspirin on development of CAAs is inconclusive. During the acute phase of illness, aspirin should be administered at high (50-100 mg/kg/day) or moderate (30-50 mg/kg/day) doses 6-8 hourly [59,60]. Anti-inflammatory dose of aspirin is usually continued until 48-72 h after the patient becomes afebrile.…”
Section: Aspirin and Anticoagulation Therapymentioning
confidence: 99%
“…However, effect of aspirin on development of CAAs is inconclusive. During the acute phase of illness, aspirin should be administered at high (50-100 mg/kg/day) or moderate (30-50 mg/kg/day) doses 6-8 hourly [59,60]. Anti-inflammatory dose of aspirin is usually continued until 48-72 h after the patient becomes afebrile.…”
Section: Aspirin and Anticoagulation Therapymentioning
confidence: 99%
“…11 All children should receive high-dose aspirin in addition to IVIG: Incorrect While aspirin (ASA) has been almost universally used in treatment of KD since its first description, it has not been shown in randomised control trials to prevent CAA at any dose. 12 Some centres give high-dose ASA for anti-inflammatory effect during the acute illness, at doses ranging from 30 to 100 mg/kg/day and for variable duration. All children should receive at least low-dose ASA (3-5 mg/kg/day) as an anti-platelet agent until follow-up echocardiography confirms normal coronary arteries.…”
Section: A Viral Infection Makes Kd Unlikely: Incorrectmentioning
confidence: 99%
“…In patients treated with IVIG, there is no evidence that aspirin at anti-inflammatory doses (ie, 30 mg/kg/day (Europe, Australia) or 80–100 mg/kg/day (USA)) further reduces the risk of coronary artery aneurysms. Many experts therefore recommend only the use of low-dose (3–5 mg/kg/day) aspirin for its antiplatelet (antithrombotic) effects 3…”
Section: Key Points From the 2017 Aha Kawasaki Disease Guidelinementioning
confidence: 99%
“…The mainstay of acute therapy is a single infusion of IVIG with aspirin. Anti-inflammatory doses of aspirin have no added benefit over and above the anti-inflammatory effect of IVIG 3 4. Therefore, it may be reasonable to use only antiplatelet (antithrombotic) low-dose (3–5 mg/kg/day) aspirin from the outset.…”
Section: Critical Appraisalmentioning
confidence: 99%