What Effect Does Controlling Platelets Have on Atherosclerosis?

Numano, Fujío; Kishi, Yukio; Ashikaga, Takashi; Hata, Akinori; Makita, Taro; Watanabe, Ryoji

doi:10.1111/j.1749-6632.1994.tb17334.x

Cited by 10 publications

(5 citation statements)

References 6 publications

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“…15). 37 These data suggest that adhesion of platelets onto the vessel wall is the event responsible not only for the formation of thrombus, but also for causing intimal damage to the vessel wall and that prevention of platelet aggregation must be essential for the prevention of thrombus formation and vascular damage 38,39. Antiplatelet drugs, such as serotonin antagonists or thromboxane A 2 antagonists, were only partially effective in the prevention of endothelial damage.…”

Section: Plateletopathy As Atherogenesismentioning

confidence: 99%

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Numano¹

2001

Annals of the New York Academy of Sciences

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Section: Plateletopathy As Atherogenesismentioning

confidence: 99%

“…Pyridonolcarbamate and/or phthalazinol synthesized by us demonstrated an antiplatelet effect and prevented vascular injury. As a matter of fact, I have been maintaining many of my patients under good control by regularly monitoring and adjusting platelet aggregation activity 38…”

Section: Plateletopathy As Atherogenesismentioning

confidence: 99%

Farewell Address

Numano¹

2001

Annals of the New York Academy of Sciences

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“…It is tempting to speculate that cytokine release during platelet activation or release by endothelial cells exposed to platelet-released products may contribute to the accelerated atherosclerosis reported in uremia (5). In fact, a recent study demonstrated a cytotoxic effect of activated platelets on endothelial cells characterized by an increase of intracellular Ca2+ and a decrease of nitric oxide production, which may cause plasma1 infiltration including blood cells and lipids (21).…”

Section: Table L Percentages Of Platelets Expressing P-selectin On mentioning

confidence: 99%

In Vivo Evaluation of Platelet Activation by Different Cellulosic Membranes

et al. 1997

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rapid increase at 45 min HD reverting to baseline at 120 min HD. The degree of echinocytosis may inversely affect the ESR. Because echinocytes have a negative influence on the ESR and the number of echinocytes fluctuates during dialysis, for the ESR to have diagnostic value, it is necessary to determine the number of echinocytes and the ESR simultaneously. ReferencesBrecher G, Be& M. Present status of spiculated red cells and their relationship to the disco-echinocytes transformation: A critical review. Blood 1972;40:33344. Reinhart WH, Chien S. Red cell rheology in stomatocyteechinocyte transformation: Roles of cell geometry and cell shapes. Blood 1986671 101-8. Owen JS, Brown DJC, Harry DS, McIntyre N. Beaven GH, Isenberg H, Gratzer WB. Erythrocyte echinocytosis in liver disease. Role of abnormal plasma high density lipoproteins. J CIin Invest 1988;76:2275-85. Singh A, Reinhart WH. The influence of fractions of abnormal erythrocytes on aggregation. Eur J Clin Invest 1991;6 597-600. 5. Reinhart WH, Singh A, Straub PW. Red blood cell aggregation and sedimentation: The role of the cell shape. Br J Haematol 198973551-6. 6. Harlan WR, Shaw WA, Zeklowitz M. Echinocytes and acquired deficiency of plasma lipoproteins in burned patients. Arch Intern Med 1976;136714. 7. Hones B, Walker TF, Chahwala SB, Thompson MG, Hick-man JA. The effect of phorbol esters on human erythrocyte morphological discocyte-echinocyte transition. Exp Cell Res 8. Udden MM, O'Rear Ed.A, Kegel H, McIntire LV, Lynch EC. Decreased deformability of exythrocytes and increased intracellular calcium in Datients with chronic renal failure. Clin Hemorheol 1984,44?3-81. Gillertt MPT, Teixeira V, Dimenstein R. Decreased plasma 1ecithin:cholesterol acyltransfer and associated changes in plasma and red cell lipids in uremia. Nephrol Dial Transplant Schardt W, Wardle EN. Plasma lysolecithin in uraemia. Clin Chim Acta 1975;63:223-5. Goldberg DM, Chajek-Shad T. Effect of chronic heparin administration on serum lipolytic activity and some aspects of lipid metabolism. Biochim Eiophys Actu 1990;1047:103-11. Reinhart WH, Chien S. Echinocyte-Stomatocyte transformation and shape control of human red blood cells: Morphological aspects. A m J Hematol 1987;241-14. Jain SK. The accumulation of malynyldialdehyde. a product of fatty acid peroxidation, can disturb aminophospholipid organizations in the membrane bilayer of human erythrocytes. J Biol Chem 1984,259:33914. Luciak M, Trznadel K. Free oxygen species metabolism during haemodialysis with different membranes. Nephrol Dial Transplant 1991;66670. Neveceral P, Markert M, Wanters 1P. Role of protein adsorption on haemodialysis induced complement activation and neutrophil defects. Nephrol Dial Transplant 1995;103724. Kon K, Maeda N, Shiga T. The influence of deformation of transformed erythrocytes during flow on the rate of oxygen release.Abstract: This study was undertaken to evaluate platelet activation in vivo induced by different cellulosic membranes by measuring the expression of P-selectin on the platelet surface du...

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“…Platelets play important roles in hemostasis, with activated platelets adhering to injured vessel walls and then initiating platelet aggregation (24). At the same time platelets have cytotoxic effects on endothelial cells that are manifested by increased levels of Ca 2+ and decreased levels of EDRF (endothelial cell relaxing factor/nitric oxide).…”

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Coronary heart disease: How do the benefits of ω‐3 fatty acids compare with those of aspirin, alcohol/red wine, and statin drugs?

Basu

Pernecky

Sengupta

et al. 2006

J Americ Oil Chem Soc

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At the present time the primary cause of death of most Americans is cardiovascular disease. Approximately 20 million Americans are currently being treated with some form of statin drugs as a means to lower their blood cholesterol levels, and many of these same people also consume some combination of omega‐3 FA, aspirin, and alcohol/red wine because of clinical data indicating that each of these, taken alone, seems to improve mortality. Recent studies with omega‐3 FA have demonstrated a positive impact on mortality from coronary heart disease as well as from “all causes,” and this article compares their metabolic benefits with those of aspirin, alcohol/red wine, and statin drugs. The article suggests that these four compounds may have synergistic qualities and that clinical trials to study this possibility are warranted.

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What Effect Does Controlling Platelets Have on Atherosclerosis?

Cited by 10 publications

References 6 publications

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Farewell Address

In Vivo Evaluation of Platelet Activation by Different Cellulosic Membranes

Coronary heart disease: How do the benefits of ω‐3 fatty acids compare with those of aspirin, alcohol/red wine, and statin drugs?

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