With the Ebola virus outbreak in West Africa, it is expected that whatever the transmitting cause and spread of the virus, it has affected the economic, political and socio-economy activities with an immense strain on the health sector. The scope of this study is the most populous nation in Africa, Nigeria. The quantitative method adopted provided results from questionnaires, which were analysed and resulted in providing the underlined significant role of globalisation in the development of Nigeria business activities and socio-psychological impact of the epidemic virus on globalisation. This is in line with the cross-border spread of the disease in generating bi-lateral strain amongst the affected countries, thus been envisioned from the spread of Ebola Virus. In the course of the paper, epidemics of such degrees in the past were reviewed by looking at how they surfaced, resurfaced and combated. The paper stresses on the role of globalisation in spreading, maintaining and eliminating the virus and its socio-economic implications in Nigeria and her related activities. This paper concludes that Nigerians are aware of the socio-economic benefits and ills of globalisation and they are convinced that the country had been impacted by it. Notably, disasters are proposed to be preventable with adequate systemized agency who will be saddled with epidemic control in Nigeria, resulting in a continuous notable success rather than having a haphazard control mechanism with business activities in negativity aside its disruption.