What, if all alerts were specific – Estimating the potential impact on drug interaction alert burden

Pilot evaluation of an optimized context-specific drug–drug interaction alerting system: A controlled pre-post study

“…We found only one study that described the implementation of this type of customization and the authors did not report the effect on alert specificity and overriding [31]. Although the inclusion of context factors in the CDS logic for adjustment of the severity of a DDI alert was proposed in several studies, the implementation of context-aware DDI screening systems is limited [15,17,30,45]. Duke et al [16] reported that they implemented a contextaware DDI screening system (i.e.…”

“…Optimizing strategies for improving alert specificity were also proposed by Seidling et al [15]. They reported that for the vast majority (n = 83) of a subset of 100 critical DDI alerts, the alert severity depends on individual patient data, factors related to the prescription, the co-medication, or combinations of these.…”

Potential drug-related problems detected by electronic expert support system: physicians’ views on clinical relevance

“…Perhaps the results indicate DDI alerts involving acetylsalicylic acid being less clinically relevant. These results are valuable for increasing the specificity of alerts [42,43]. Table 2 The 10 most common substances prescribed in the study population (n = 2868 medications), involved in alerts (n = 1141 medications), and changed as stated for an alert (n = 94)…”

Drug-interactions of azole antifungals with selected immunosuppressants in transplant patients: strategies for optimal management in clinical practice

“…Ideally, no 'alert fatigue' exist and warnings are tailored and graded for severity to increase the usefulness for assessment of DDIs [20,21]. So, if well designed, this tool can facilitate decision-making DDIs of azoles with immunosuppressants Lempers et al 39…”