The unprecedented outbreak of the COVID-19 pandemic has forced governments to devise national strategies to curtail its spread. The present study analyzes the national strategies of India and the United States for the COVID-19 vaccine roll out. The paper presents an ontology of COVID-19 vaccine roll out, maps the national strategies, identifies, analyzes the emphases and gaps in them, and proposes corrections to the same. The analysis shows that the national strategies are selective in their focus and siloed in their approach. They must be systematized to address the emerging challenges effectively. Thus, there is need for a systemic understanding and analysis to reinforce the effective pathways to manage vaccine roll out, reposition the ineffective ones, and engineer new ones through feedback and learning.