What is infection?

Thomson, Philip D.; Smith, David J.

doi:10.1016/0002-9610(94)90003-5

Cited by 78 publications

(34 citation statements)

References 13 publications

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“…A swab sample can also provide a semiquantitative estimation of the microbial load (e.g., light growth to heavy growth, or Ͼ10 5 CFU/ml), which is considerably easier to perform than a fully quantitative analysis. A correlation between semiquantitative swab data and quantitative biopsy data has previously been demonstrated (8,23,132,139,235,239).…”

Section: Wound-sampling Methodsmentioning

confidence: 70%

“…The acquisition of deep tissue during biopsy following initial debridement and cleansing of superficial debris is recognized as being the most useful method for determining the microbial load and the presence of invasive pathogens (76,173,235). Tissue is obtained aseptically and is then weighed, homogenized, serially diluted, and cultured on selective and nonselective agar media under aerobic and anaerobic conditions to provide quantitative and qualitative information.…”

Section: Wound-sampling Methodsmentioning

confidence: 99%

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Wound Microbiology and Associated Approaches to Wound Management

2001

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The majority of dermal wounds are colonized with aerobic and anaerobic microorganisms that originate predominantly from mucosal surfaces such as those of the oral cavity and gut. The role and significance of microorganisms in wound healing has been debated for many years. While some experts consider the microbial density to be critical in predicting wound healing and infection, others consider the types of microorganisms to be of greater importance. However, these and other factors such as microbial synergy, the host immune response, and the quality of tissue must be considered collectively in assessing the probability of infection. Debate also exists regarding the value of wound sampling, the types of wounds that should be sampled, and the sampling technique required to generate the most meaningful data. In the laboratory, consideration must be given to the relevance of culturing polymicrobial specimens, the value in identifying one or more microorganisms, and the microorganisms that should be assayed for antibiotic susceptibility. Although appropriate systemic antibiotics are essential for the treatment of deteriorating, clinically infected wounds, debate exists regarding the relevance and use of antibiotics (systemic or topical) and antiseptics (topical) in the treatment of nonhealing wounds that have no clinical signs of infection. In providing a detailed analysis of wound microbiology, together with current opinion and controversies regarding wound assessment and treatment, this review has attempted to capture and address microbiological aspects that are critical to the successful management of microorganisms in wounds

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Section: Wound-sampling Methodsmentioning

confidence: 70%

Section: Wound-sampling Methodsmentioning

confidence: 99%

Wound Microbiology and Associated Approaches to Wound Management

2001

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“…In the absence of objective data indicative of infection, treatment of colonization is usually avoided due to its cost and the risk of adverse reactions and of induction of microbial resistance. The standard definitions of infection and colonization are not helpful clinically in determining the significance of the isolation of certain microbes from wounds and body sites that are normally sterile (49). At present, efforts to establish guidelines for the treatment of states of microbial colonization in the hospital setting are limited by an inadequate understanding of the pathogenesis of colonization and the aspects of the host-microbe relationship that influence the development of infection after colonization.…”

Section: Inadequacy Of Lexicon In Clinical Practicementioning

confidence: 99%

“…Ancient usage of this term includes the idea that disease was caused by invisible agents that entered the body (17). However, whereas some authors consider an infection to be the outcome of a tissue invasion (26,49), others have used the word to include initial contact between parasite and host (42,55,56) and others have defined the term to include disease causation (4,15).…”

Section: Integrated Lexicon To Describe Host-pathogen Interactionmentioning

confidence: 99%

Host-Pathogen Interactions: Basic Concepts of Microbial Commensalism, Colonization, Infection, and Disease

2000

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“…B. bei β-hämo-lysierenden Streptokokken von Bedeutung [19,34]. Semiquantitative Wundabstriche erwiesen sich als hilfreich, um die Ausprägung der Bakterienzahl einordnen zu können, obgleich es keinen spezifischen Grenzwert gibt [39].…”

Section: Diagnoseunclassified