What Is New from the Canadian Paediatric Society Committee on Infectious Diseases and Immunization?

Robinson, Joan

doi:10.1155/2014/861346

Cited by 5 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both age and sex modulate UTI incidence. It is estimated that 8-10% of girls and 2-3% of boys will suffer from a symptomatic urinary infection before the age of 7 [3][4][5][6][7][8]. Between 50 and 80% of patients with febrile UTI have acute pyelonephritis (APN) [9].…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone to prevent kidney scarring in acute pyelonephritis: a randomized clinical trial

et al. 2022

View full text Add to dashboard Cite

Background Urinary tract infection (UTI) is one of the most common bacterial infections in childhood and is associated with long-term complications. We aimed to assess the effect of adjuvant dexamethasone treatment on reducing kidney scarring after acute pyelonephritis (APN) in children. Methods Multicenter, prospective, double-blind, placebo-controlled, randomized clinical trial (RCT) where children from 1 month to 14 years of age with proven APN were randomly assigned to receive a 3-day course of either an intravenous corticosteroid (dexamethasone 0.30 mg per kg/day) twice daily or placebo. The late technetium 99 m-dimercaptosuric acid scintigraphy (> 6 months after acute episode) was performed to assess kidney scar persistence. Kidney scarring risk factors (vesicoureteral reflux, kidney congenital anomalies, or urinary tract dilatation) were also assessed. Results Ninety-one participants completed the follow-up and were finally included (dexamethasone n = 49 and placebo n = 42). Both groups had similar baseline characteristics. Twenty participants showed persistent kidney scarring after > 6 months of follow-up without differences in incidence between groups (22% and 21% in the dexamethasone and placebo groups, p = 0.907). Renal damage severity in the early DMSA (β = 0.648, p = 0.023) and procalcitonin values (β = 0.065 p = 0.027) significantly modulated scar development. Vesicoureteral reflux grade showed a trend towards significance (β = 0.545, p = 0.054), but dexamethasone treatment showed no effect. Conclusion Dexamethasone showed no effect on reducing the risk of scar formation in children with APN. Hence, there is no evidence for an adjuvant corticosteroid treatment recommendation in children with APN. However, the study was limited by not achieving the predicted sample size and the expected scar formation. Trial registration Clinicaltrials.gov, NCT02034851. Registered in January 14, 2014. Graphical abstract “A higher resolution version of the Graphical abstract is available as Supplementary information.”

show abstract

Section: Introductionmentioning

confidence: 99%

Dexamethasone to prevent kidney scarring in acute pyelonephritis: a randomized clinical trial

et al. 2022

View full text Add to dashboard Cite

show abstract

“…UTIs, including cystitis and pyelonephritis, are the most common infectious diseases in childhood [2]. E. coli accounts for as much as 90% of the community-acquired and 50% of the nosocomial UTIs [3].…”

Section: Introductionmentioning

confidence: 99%

Isolation of Pathogenic Gram-Negative Bacteria from Urinary Tract Infected Patients

Salih¹,

Alrabadi²,

Thalij³

et al. 2016

OJMM

View full text Add to dashboard Cite

This study investigated the susceptibility pattern of different bacteria isolated from urinary tract infection to different antibiotics. 83 uropathogen bacteria were isolated from 300 urine samples taken from patients attended to Tikrit Teaching Hospital from March, 2011 through February, 2012. The patients were males and females aged between 4 days to 95 years. Bacteria obtained from urine samples were cultured and tested for antimicrobial susceptibility to 16 kinds of antibiotics. Urine samples were cultured on different media and incubated, thereafter bacteria were isolated and purified by streaking four times on the same media; isolates were identified depending on morphological, microscopic, and biochemical characteristics. The isolated strains of bacteria were tested for their susceptibility to some antibiotics using disk diffusion method. The antagonistic activity was evaluated by observing a clear zone of inhibition growth. The results showed that the bacterial species of Eschericia coli, Proteus mirabilis, Klebsiella pneumonia, Citrobacter diversus, Citrobacter freundii, Enterobacter aerogenes, Yersinia pestis, Pseudomonas aeruginosa, Klebsiella oxytoca and Hafnia alvei were identified in 44 (53%), 18 (21.7%), 4 (4.8%), 4 (4.8%), 3 (3.6%), 3 (3.6%), 3 (3.6%), 2 (2.4%), 1 (1.2%) and 1 (1.2%), respectively, of the isolates. The results of antimicrobial susceptibility test showed that 83 (100%) isolates were resistant to Ampicillin, Rifampicin and Erythromycin. 75 (90.3%) isolates were resistant to Cefotaxime, 67 (80.7%) isolates were resistant to Tobramyci. 66 (79.5%), 65 (78.3%), 56 (67.4%) and 48 (57.8%) isolates showed susceptibility to Nalidixic acid, Tetracycline, Nitrofurantoin, Chloramphenicol, respectively. 45 (54.2%) isolates were resistant to Azithromycin, Norfloxacin and Ciprofloxacin. Meropenem, Gentamicin, Amikacin, and Imipenem show significant effect on 35 (42.1%), 32 (38.5%), 27 (32.5%) and 1 (1.2%) isolates, respectively. In conclusion, significant bacteria count isolated from urine samples is pathogenic. The most effective antibiotic in inhibiting the bacterial growth M. K. Salih et al. 60was Imipenem while Ampicillin, Rifampicin and Erythromycin showed no effect on all 83 isolates (100%).

show abstract

“…The Pediatricians of Ontario position is intended to provide medical opinion, in addition to statements issued by the National Advisory Committee on Immunization (NACI) ( 6 , 7 ) and/or Canadian Immunization Committee, and the Canadian Paediatric Society ( 8 , 9 ). In advocating the benefits of 4CMenB immunization to public health policy makers and to Ontario pediatricians in frontline practice, the present position paper should broaden the use of the 4CMenB vaccine ( Figure 1; bold arrows ).…”

Section: Unique Contribution Of the Pediatricians Of Ontario In Shapimentioning

confidence: 99%

The Role of Pediatricians as Key Stakeholders in Influencing Immunization Policy Decisions for the Introduction of Meningitis B Vaccine in Canada: The Ontario Perspective

Yamashiro¹,

Cutcliffe²,

Dobson³

et al. 2015

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Invasive meningococcal disease is a rapidly progressing infection that can lead to death within 24 h of onset or cause serious life-threatening disabilities. Serogroup B is now the most common form in Canada. In Ontario, the Pediatrics Section of the Ontario Medical Asso ciation and the Pediatricians Alliance of Ontario have developed five recommendations regarding immunization policy with a primary focus on providing the vaccine for children. The recommendations presented by the authors are intended to assist practicing clinicians in advocating for the benefits of the new serogroup B vaccine and to spark discussion and build consensus regarding vaccination policies.

show abstract

What Is New from the Canadian Paediatric Society Committee on Infectious Diseases and Immunization?

Cited by 5 publications

References 13 publications

Dexamethasone to prevent kidney scarring in acute pyelonephritis: a randomized clinical trial

Dexamethasone to prevent kidney scarring in acute pyelonephritis: a randomized clinical trial

Isolation of Pathogenic Gram-Negative Bacteria from Urinary Tract Infected Patients

The Role of Pediatricians as Key Stakeholders in Influencing Immunization Policy Decisions for the Introduction of Meningitis B Vaccine in Canada: The Ontario Perspective

Contact Info

Product

Resources

About