What Is the Effect of Metabolic Syndrome without Hypertension on Left Ventricular Hypertrophy?

Al-Daydamony, Mohammad M.; Tahlawi, Mohammad El

doi:10.1111/echo.13247

Cited by 21 publications

(9 citation statements)

References 28 publications

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“…In this respect, our findings are also in agreement with those reported by Al-Daydamony and El-Tahlawi et al, who found a significant positive correlation between LVMI and TG levels in patients with metabolic syndrome without hypertension [27].…”

Section: Discussionsupporting

confidence: 93%

Lipid profile and left ventricular geometry pattern in obese children

et al. 2020

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Background: Left ventricular hypertrophy (LVH) is an important risk factor for cardiovascular and all-cause mortality. Previous studies reported conflicting results concerning the relationship between serum lipid levels and left ventricular geometry pattern. We sought to explore the relationship between standard serum lipid profile measures with left ventricular geometry pattern in obese children. Patients and methods: In this cross-sectional study, a total of 70 obese children were examined. Fasting blood samples were taken to measure total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TGs), glucose, and insulin. Based on these values TG/HDL ratio, BMI and HOMA index were calculated. We also measured the average 24-h ambulatory systolic blood pressure (SBP) and two-dimensional (2/D) transthoracic echocardiography was performed to determine left ventricular mass index (LVMI) and relative wall thickness (RWT). Multiple regression analyses were conducted to explore relationships between study variables and the LVMI or RWT as outcome variables. The final model with LVMI included TG/HDL ratio, BMI, 24 h-average SBP, age and sex, while for the RWT we included BMI, insulin, age and sex. Results: Our study included 70 children (65.71% boys and 34.29% girls) median age (14 years, IQR = 12-16)." We demonstrated independent and positive association of TG/HDL ratio, BMI and 24 h-average SBP with LVMI (effect = 3.65, SE = 1.32, p < 0.01; effect = 34.90, SE = 6.84, p < 0.01; effect = 0.32, SE = 0.12, p < 0.01, respectively). On the other hand, in model with RWT as outcome variable, only BMI and insulin were significantly linked (BMI: effect = 13.07, SE = 5.02, p = 0.01 Insulin: effect = 2.80, SE = 0.97). Conclusion: Increased TG/HDL ratio in obese children is associated with the development of eccentric left ventricular hypertrophy while increased BMI and insulin were associated with concentric left ventricular hypertophy.

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Section: Discussionsupporting

confidence: 93%

Lipid profile and left ventricular geometry pattern in obese children

et al. 2020

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Section: Discussionsupporting

confidence: 93%

Lipid profile and left ventricular geometry pattern in obese children

Bjelaković

Stefanutti

Vuković

et al. 2020

Preprint

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Background: Left ventricular hypertrophy (LVH) is an important risk factor for cardiovascular and all-cause mortality. Previous studies reported conflicting results concerning the relationship between serum lipid levels and left ventricular geometry pattern. We sought to explore the relationship between standard serum lipid profile measures with left ventricular geometry pattern in obese children. Patients and methods : In this cross-sectional study, a total of 70 obese children were examined. Fasting blood samples were taken to measure total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TGs), glucose, and insulin. Based on these values TG / HDL ratio, BMI and HOMA index were calculated. We also measured the average 24-hour ambulatory systolic blood pressure (SBP) and two-dimensional (2/D) transthoracic echocardiography was performed to determine left ventricular mass index (LVMI) and relative wall thickness (RWT). Multiple regression analyses with stepwise selection were conducted to explore relationships between study variables and the LVMI or RWT as outcome variables. The final model with LVMI included TG/HDL ratio, BMI, 24h-average SBP, age and sex, while for the RWT we included BMI, insulin, age and sex. Results : Our study included 70 children (65.71% boys and 34.29% girls) with median age (14 years, IQR=12-16)." We demonstrated independent and positive association of TG/HDL ratio, BMI and 24h-average SBP with LVMI (effect=3.65, SE=1.32, p<0.01; effect=34.90, SE=6.84, p<0.01; effect=0.32, SE=0.12, p<0.01, respectively). On the other hand, in model with RWT as outcome variable, only BMI and insulin were significantly linked (BMI: effect=13.07, SE=5.02, p=0.01 Insulin: effect=2.80, SE=0.97). Conclusion: Increased TG/HDL ratio in obese children is associated with the development of eccentric left ventricular hypertrophy while increased BMI and insulin were associated with concentric left ventricular hypertophy.

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“…Results from a study by Al-Daydamony MM et al [7] investigated the impact of metabolic syndrome (MetS) on LVM in a population with and without hypertension and their findings support our results. They found a significantly positive correlation between increased LVM and fasting blood glucose (r = 0.52, P < 0.0001), but also a significantly positive correlation between LVM and HbA1c (r = 0.42, P < 0.0001).…”

Section: Discussionsupporting

confidence: 88%

“…Increased LVM is associated with increased all-cause mortality [1, 2] and recurrent MI [4]. Hypertension [5] and aortic valve stenosis [6] are well-known causes of increased LVM, but dysglycemia has also been thought to influence LVM [7, 8]. The prevalence of dysglycemia is increasing worldwide and is a well-known risk factor of cardiovascular disease, which increases morbidity and mortality [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Dysglycemia and increased left ventricle mass in normotensive patients admitted with a first myocardial infarction: prognostic implications of dysglycemia during 14 years of follow-up

Pararajasingam

Løgstrup

Høfsten

et al. 2019

BMC Cardiovasc Disord

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Background Left ventricle mass (LVM) can be influenced by various conditions including hypertension and/or inherent cardiomyopathies. Dysglycemia is also thought to exert an anabolic effect on heart tissue by hyperinsulinemia and thereby promoting increased LVM. The primary aim of this study was to assess the influence of dysglycemia on LVM evaluated by an oral glucose tolerance test (OGTT) in patients admitted with a first myocardial infarction (MI) without hypertension. The secondary aim was to assess the impact of dysglycemia on major adverse cardiovascular events (MACE) and all-cause mortality during long-term follow-up. Methods Patients admitted with a first MI without known history of hypertension were included. All patients without previously known type 2 diabetes mellitus (T2DM) had a standardized 2-hour OGTT performed and were categorized as: normal glucose tolerance (NGT), impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) and newly detected T2DM (new T2DM). LVM was measured by echocardiography using Devereaux formula and indexed by body surface area. Multivariate linear regression analysis was used to assess the impact of confounders (dysglycemia by OGTT, known T2DM, age, sex and type of MI) on LVM. Cox proportional hazard model was used to assess the impact of dysglycemia on all-cause mortality and a composite endpoint of MACE (all-cause mortality, MI, revascularisation due to stable angina, coronary artery bypass graft, ischemic stroke or hemorrhagic stroke). Results Two-hundred-and-five patients were included and followed up to 14 years. In multivariate regression analysis, LVM was only significantly increased in patients categorized as new T2DM (β = 25.3; 95% CI [7.5–43.0]) and known T2DM (β = 37.3; 95% CI [10.0-64.5]) compared to patients with NGT. Patients with new T2DM showed higher rates of MACE and all-cause mortality compared to patients with IFG/IGT and NGT; however no significantly increased hazard ratio was detected. Conclusions Dysglycemia is associated with increasing LVM in normotensive patients with a first acute myocardial infarction and the strongest association was observed in patients with new T2DM and patients with known T2DM. Dysglycemia in normotensive patients with a first MI is not an independent predictor of neither MACE nor all-cause mortality during long-term follow-up compared to normotensive patients without dysglycemia. Electronic supplementary material The online version of this article (10.1186/s12872-019-1084-5) contains supplementary material, which is available to authorized users.

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What Is the Effect of Metabolic Syndrome without Hypertension on Left Ventricular Hypertrophy?

Abstract: Even in the absence of hypertension, MetS patients had significantly higher LV wall thickness, LV mass and LVMI, and incidence of LVH than control subjects.

Cited by 21 publications

References 28 publications

Lipid profile and left ventricular geometry pattern in obese children

Lipid profile and left ventricular geometry pattern in obese children

Lipid profile and left ventricular geometry pattern in obese children

Dysglycemia and increased left ventricle mass in normotensive patients admitted with a first myocardial infarction: prognostic implications of dysglycemia during 14 years of follow-up

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