What is the most relevant standard of success in assisted reproduction?: Is BESST (birth emphasizing a successful singleton at term) truly the best?

Griesinger, Georg

doi:10.1093/humrep/deh237

Cited by 36 publications

(24 citation statements)

References 9 publications

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“…A broad discussion on this topic has already taken place. For regular IVF, a good standard appears to be the term singleton live birth rate per initiated ART cycle (Min et al, 2004) or alternatively the live birth rate per ovarian stimulation started (Griesinger et al, 2004), whereby the percentage of multiple pregnancies is specified.…”

Section: Specific Data To Be Offered To Candidate-freezersmentioning

confidence: 99%

Social egg freezing: for better, not for worse

Mertes

Pennings

2011

Reproductive BioMedicine Online

104

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The possibility for healthy women to cryopreserve their oocytes in order to counter future infertility has gained momentum in recent years. However, women tend to cryopreserve oocytes at an age that is suboptimal from a clinical point of view -in their late thirties -when both oocyte quantity and quality have already considerably diminished and success rates for eventually establishing a pregnancy are thus limited. This also gives rise to ethical concerns, as the procedure is seen as giving false hope to (reproductively speaking) older women. We evaluate which measures can be taken to turn social freezing into a procedure that is both clinically and ethically better than the current practice. The main objective of these measures is to convince those women who are most likely to (want to) reproduce at an above average age to cryopreserve their oocytes at a time when this intervention is still likely to lead to a life birth and to discourage fertility clinics from specifically targeting women who have already surpassed the age at which good results can be expected.

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Section: Specific Data To Be Offered To Candidate-freezersmentioning

confidence: 99%

Social egg freezing: for better, not for worse

Mertes

Pennings

2011

Reproductive BioMedicine Online

104

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“…For trials to be eligible, we had to be able to extract data on at least one of the following outcomes, as recommended [14][15][16][17] : clinical pregnancy (that is, presence of at least one gestational sac or fetal heartbeat, confirmed by transvaginal ultrasound 18 ), ongoing pregnancy (that is, pregnancy beyond 12 weeks of gestation, as confirmed by fetal heart activity on ultrasound), or live birth. We included cross over trials only if relevant outcome data from the first phase (that is, before the cross over occurred) were available.…”

Section: Identification Of Studiesmentioning

confidence: 99%

Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis

Manheimer

Zhang

Udoff

et al. 2008

BMJ

174

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“…We also must take into consideration the underlying cause of infertility. Some researchers favor the expansion of eSET criteria [35], while others oppose such an expansion [36,37], and there is no common consensus worldwide [38][39][40][41]. The development of the technology that can expand the implementation of eSET with strict safeguards should result in an overall improvement of ART.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of possible criteria for elective single embryo transfer

Sato

Fukuda

Kanamori

et al. 2010

Reprod Medicine & Biology

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Purpose A major problem of assisted reproductive technology (ART) is multiple gestation, which impacts neonatal and perinatal medicine. The literature contains a number of reports that elective single embryo transfer (eSET) is effective for the control of multiple pregnancies; however, to date, uniform criteria have not been established. Methods Using logistic regression analysis based on the results of ART in our department from January 2005 to July 2006, our eSET criteria were established. We conducted a comparative study of the clinical pregnancy rate, multiple gestation rate, and delivery rate before and after eSET (before-eSET and after-eSET groups, respectively). Results As a result of the analysis, our eSET criteria included all three of the following: (A) patient age B37, (B) previous IVF/ICSI trials B5, and (C) acquisition of two or more good-quality embryos. Based on our criteria, the after-eSET group was not found to have a decrease in the pregnancy rate; however, the multiple gestation rate decreased as compared to the before-eSET group. In addition, as a result of various evaluations of the eSET group, interesting findings were revealed. Conclusions In the after-eSET group, our eSET criteria achieved a decrease in the multiple pregnancy rate without a decrease in the pregnancy rate.

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What is the most relevant standard of success in assisted reproduction?: Is BESST (birth emphasizing a successful singleton at term) truly the best?

Cited by 36 publications

References 9 publications

Social egg freezing: for better, not for worse

Social egg freezing: for better, not for worse

Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis

Evaluation of possible criteria for elective single embryo transfer

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