What is the ongoing activity of sympathetic neurons?

Skok, V. I.; Ivanov, A. Ya.

doi:10.1016/0165-1838(83)90079-6

Cited by 45 publications

(45 citation statements)

References 7 publications

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“…In addition, anatomical studies show that there is considerable branching of individual preganglionic axons to innervate from 50 to 200 ganglion cells (Purves & Wigston, 1983). Since many preganglionic inputs are subthreshold, several inputs must sum to generate an action potential in the ganglion cell (McLachlan, 1974;Skok & Ivanov, 1983). Therefore, a loss of tonic activity (by blockade of the RVLM) in a small number of preganglionic axons could cause the loss of activity in many postganglionic neurones.…”

Section: K Ha Yes and L C 1ea Vrermentioning

confidence: 99%

Selective control of sympathetic pathways to the kidney, spleen and intestine by the ventrolateral medulla in rats.

Hayes

Weaver

1990

The Journal of Physiology

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SUMMARY1. Electrical activity of multifibre renal, splenic, mesenteric and greater splanchnic nerves and 13th thoracic white rami was recorded in artificially respired, urethaneanaesthetized rats. Discharge of neurones in the rostral ventrolateral medulla was blocked by unilateral microinjections of the inhibitory amino acid glycine and effects on the electrical activity of these sympathetic nerves were compared.2. Blockade of the rostral ventrolateral medulla caused greater decreases in discharge of renal than splenic nerves and had no consistent effect on mesenteric nerves. This blockade also decreased the discharge of the preganglionic white rami more than that of the preganglionic splanchnic nerves.3. Postganglionic responses to rostral ventrolateral medulla blockade were always greater than preganglionic responses.4. The arterial pressure and renal nerve responses to rostral ventrolateral medulla blockade in urethane-anaesthetized rats were not different from those in rats anaesthetized with a-chloralose.5. These findings demonstrate that pre-and postganglionic sympathetic pathways to the kidney are more dependent upon excitatory drive from the rostral ventrolateral medulla than pathways directed to the spleen and intestine.

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Section: K Ha Yes and L C 1ea Vrermentioning

confidence: 99%

Selective control of sympathetic pathways to the kidney, spleen and intestine by the ventrolateral medulla in rats.

Hayes

Weaver

1990

The Journal of Physiology

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“…Phasic neurones receive one or a few large, suprathreshold synaptic inputs from preganglionic motor neurones located in the spinal cord (Skok & Ivanov, 1983;Hirst & McLachlan, 1986). As a consequence, they function primarily as relay neurones connecting the central nervous system to peripheral organs.…”

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confidence: 99%

Potassium currents in rat prevertebral and paravertebral sympathetic neurones: control of firing properties.

Wang

McKinnon

1995

The Journal of Physiology

124

134

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1. Intracellular recordings were made from rat sympathetic neurones in isolated superior cervical ganglia (SCG), coeliac ganglia (CG) and superior mesenteric ganglia (SMG). 2. Based on their response to a maintained depolarizing current stimulus, neurones were classified as 'phasic' or 'tonic'. All neurones in the SCG were phasic, 85 % of the neurones in the SMG and 58 % of the neurones in the CG were tonic, and the remainder were phasic.3. The voltage response of phasic and tonic neurones around threshold to a constant current step was markedly different. The response of phasic neurones was biphasic with an initial depolarizing response followed by significant repolarization of the membrane potential. In contrast, tonic neurones became more depolarized during a prolonged current step. 4. The underlying currents were studied using single-electrode voltage-clamp recording. The M-current was present in all phasic neurones, but was very weak or absent in tonic neurones. 5. An A-current was apparent in both phasic and tonic neurones. The voltage-dependent activation, steady-state inactivation, and current density of the A-current were all similar in phasic and tonic cells. 6. A low-threshold, slowly inactivating outward current (D2-current) was observed exclusively in tonic neurones. The slow inactivation of this current appeared to underlie the slow depolarizing ramp seen in response to a maintained depolarizing current step. 7. Computer simulations, based on the voltage-clamp data, suggested that the different firing properties of phasic and tonic neurones could be accounted for by differential expression of the M-current.

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“…1. The shape of APs generated by most of these neurons (the absence of "a step" on the rising phase) corresponds to that of APs of the so-called type 1 earlier recorded in the BA of SCG neurons in the rabbit [2,8] and rat [7]. Such APs are known to be evoked by presynaptic activation via a single preganglionic fiber [8].…”

Section: Resultsmentioning

confidence: 98%

“…The activity of SCG neurons of the rat was recorded using an approach similar to the earlier described [7,8]. Animals were anesthetized by urethane (i.p., 1.0 g/kg).…”

Section: Methodsmentioning

confidence: 99%

Background Activity of Neurons of the Superior Cervical Ganglion That Innervate the Submandibular Gland in the Rat

Maslov

2005

Neurophysiology

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In in situ acute experiments, we intracellularly recorded the background activity (BA) from neurons of the superior cervical ganglion, which were antidromically identified by stimulation of the postganglionic nerve in close proximity to the submandibular salivary gland of the rat. According to the pattern of BA, these neurons could be classified into two groups; the respective units probably differ from each other in the number of active converging synaptic inputs. We hypothesize that these neurons are involved in the control of different aspects of function of the gland.

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What is the ongoing activity of sympathetic neurons?

Cited by 45 publications

References 7 publications

Selective control of sympathetic pathways to the kidney, spleen and intestine by the ventrolateral medulla in rats.

Selective control of sympathetic pathways to the kidney, spleen and intestine by the ventrolateral medulla in rats.

Potassium currents in rat prevertebral and paravertebral sympathetic neurones: control of firing properties.

Background Activity of Neurons of the Superior Cervical Ganglion That Innervate the Submandibular Gland in the Rat

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