What is the Optimal Preoperative Imaging Modality for Assessing Peritoneal Cancer Index? An Analysis From the United States HIPEC Collaborative

Lee, Rachel; Zaidi, Mohammad Y.; Gamboa, Adriana C.; Speegle, Shelby; Kimbrough, Charles W.; Cloyd, Jordan M.; Leiting, Jennifer L.; Grotz, Travis E.; Lee, Andrew; Fournier, Keith F.; Powers, Benjamin D.; Dineen, Seán; Baumgartner, Joel M.; Veerapong, Jula; Clarke, Callisia N.; Sussman, Jeffrey J.; Patel, Sameer H.; Hendrix, Ryan J.; Lambert, Laura; Walle, Kara A. Vande; Abbott, Daniel E.; LaRocca, Christopher J.; Raoof, Mustafa; Fackche, Nadege; Johnston, Fabian M.; Staley, Charles A.; Maithel, Shishir K.; Russell, Maria C.

doi:10.1016/j.clcc.2019.12.002

Cited by 16 publications

(13 citation statements)

References 15 publications

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“…Their studies indicated that the benefits of HIPEC diminished as the CC score increased, and CC score was the most significant independent prognostic factor for patient survival ( Glehen et al, 2004 ). As expected, patients undergoing incomplete cytoreduction faced increased morbidity with poorer survival ( Lee et al, 2020 ).…”

Section: Introductionmentioning

confidence: 77%

Concurrent hysterectomy and bilateral salpingo-oophorectomy during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for non-gynecologic cancers

Riggs

Lin

Kim

et al. 2020

Gynecologic Oncology Reports

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Section: Introductionmentioning

confidence: 77%

Concurrent hysterectomy and bilateral salpingo-oophorectomy during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for non-gynecologic cancers

Riggs

Lin

Kim

et al. 2020

Gynecologic Oncology Reports

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“…Contrast-enhanced CT is generally considered as the preferred first-line diagnostic imaging modality for detecting peritoneal metastasis in clinical practice considering its low cost and fast scanning time. Compared to CT, the use of MRI can improve the sensitivity for detecting small peritoneal tumors owing to its ability to provide different soft tissue contrast by modifying the imaging sequences and parameters [ 16 , 17 ]. However, MRI is sensitive to motion artifacts and the MRI image quality may degrade in patients with poor breath-hold capability and contraindications to antiperistaltic agents.…”

Section: Discussionmentioning

confidence: 99%

“…Very few studies have compared the performance of CT-PCI and MRI-PCI for patients with peritoneal metastasis from a specific type of cancer. In patients with colon cancer, Lee et al [ 17 ] reported a fair agreement between CT-PCI and OP-PCI (ICC = 0.359) and an almost perfect agreement between MRI-PCI and OP-PCI (ICC = 0.854). Similar results were reported by van ‘t Sant et al [ 19 ], who reported a fair to moderate agreement between CT-PCI and OP-PCI (ICC = 0.39 to 0.44) and an almost perfect agreement between MRI-PCI and OP-PCI (ICC = 0.83 to 0.88).…”

Section: Discussionmentioning

confidence: 99%

Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction

Lin

Huang

et al. 2021

Diagnostics

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Background: This study aimed to investigate the adding value of MRI over CT for preoperative cytoreductive surgery with hyperthermic intraperitoneal chemotherapies (CRS/HIPEC). Methods: Imaging and intraoperative peritoneal cancer index (PCI) were calculated in 62 patients with peritoneal metastasis. Predictive models for the completeness of cytoreductive score using PCI data were established using decision tree algorithms. Results: In gastric cancer patients, a large discrepancy and poor agreement was appreciated between CT and surgical PCI, and a nonsignificant difference was noted between MRI and surgical PCI. In colon cancer patients, a better agreement and higher correlation with a smaller error was observed in PCI score using MRI than in that using CT. However, the addition of MRI to CT was limited for appendiceal and ovarian cancer patients. For predicting incomplete cytoreduction, CT models yielded inadequate accuracy while MRI models were more accurate with fair discrimination ability. Conclusions: CT was suitable for estimating PCI and surgery outcome in appendiceal and ovarian cancer patients, while further MRI in addition to CT was recommended for colon and gastric cancer patients. However, for classifying patients with peritoneal carcinomatosis into complete and incomplete cytoreduction, MRI was more effective than CT.

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“…However, though radiographic PCI has been shown to correlate with intraoperative PCI, use of radiographic PCI remains controversial, and its measurement in clinical practice is not standard practice. 11 Thus, our aim was to determine purely preoperative predictors associated with OS in patients considered for concomitant LR and CRS/HIPEC using a large, multi-institutional database. Patients were categorized into two groups based on whether or not they had an LR, defined as a formal parenchymal resection.…”

Section: Introductionmentioning

confidence: 99%

“…Criteria included in the nomogram were number of liver metastases, peritoneal carcinomatosis index (PCI), and type of surgery (CRS/HIPEC alone, LR alone, or concomitant LR and CRS/HIPEC). However, though radiographic PCI has been shown to correlate with intraoperative PCI, use of radiographic PCI remains controversial, and its measurement in clinical practice is not standard practice 11 . Thus, our aim was to determine purely preoperative predictors associated with OS in patients considered for concomitant LR and CRS/HIPEC using a large, multi‐institutional database.…”

Section: Introductionmentioning

confidence: 99%

A novel preoperative risk score to optimize patient selection for performing concomitant liver resection with cytoreductive surgery/HIPEC

Lee

Gamboa

Turgeon

et al. 2020

Journal of Surgical Oncology

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Background: While parenchymal hepatic metastases were previously considered a contraindication to cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC), liver resection (LR) is increasingly performed with CRS/HIPEC. Methods: Patients from the US HIPEC Collaborative (2000-2017) with invasive appendiceal or colorectal adenocarcinoma undergoing primary, curative intent CRS/HIPEC with CC0-1 resection were included. LR was defined as a formal parenchymal resection. Primary endpoints were postoperative complications and overall survival (OS). Results: A total of 658 patients were included. About 83 (15%) underwent LR of colorectal (58%) or invasive appendiceal (42%) metastases. LR patients had more complications (81% vs. 60%; p = .001), greater number of complications (2.3 vs. 1.5; p < .001) per patient and required more reoperations (22% vs. 11%; p = .007) and readmissions (39% vs. 25%; p = .014) than non-LR patients. LR patients had decreased OS (2-year OS 62% vs. 79%, p < .001), even when accounting for peritoneal carcinomatosis index and histology type. Preoperative factors associated with decreased OS on multivariable analysis in LR patients included age < 60 years (HR,

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What is the Optimal Preoperative Imaging Modality for Assessing Peritoneal Cancer Index? An Analysis From the United States HIPEC Collaborative

Cited by 16 publications

References 15 publications

Concurrent hysterectomy and bilateral salpingo-oophorectomy during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for non-gynecologic cancers

Concurrent hysterectomy and bilateral salpingo-oophorectomy during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for non-gynecologic cancers

Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction

A novel preoperative risk score to optimize patient selection for performing concomitant liver resection with cytoreductive surgery/HIPEC

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