What is the origin of dyspnoea in smokers without airway disease?

Clini, Enrico; Beghè, Bianca

doi:10.1183/13993003.01170-2016

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…(World Health Organization, 2011) Physical inactivity, a common finding in smokers, has also been mechanistically linked to a plethora of nontransmissible diseases (World Health Organization, 2010; Lee et al, 2012). There is, therefore, increasing awareness of the link between exercise intolerance and smoking (Clini et al, 2016); moreover, the last decades witnessed a growing debate on the consequences of preclinical chronic obstructive pulmonary disease (COPD) – the prototype of a smoking-related disease – on clinical outcomes, including exercise intolerance (Caram et al, 2016; Chen et al, 2016; Rhee et al, 2017; Soriano et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Cardiopulmonary and Muscular Interactions: Potential Implications for Exercise (In)tolerance in Symptomatic Smokers Without Chronic Obstructive Pulmonary Disease

et al. 2019

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Smoking and physical inactivity are important preventable causes of disability and early death worldwide. Reduced exercise tolerance has been described in smokers, even in those who do not fulfill the extant physiological criteria for chronic obstructive pulmonary disease (COPD) and are not particularly sedentary. In this context, it is widely accepted that exercise capacity depends on complex cardio-pulmonary interactions which support oxygen (O 2 ) delivery to muscle mitochondria. Although peripheral muscular factors, O 2 transport disturbances (including the effects of increased carboxyhemoglobin) and autonomic nervous system unbalance have been emphasized, other derangements have been more recently described, including early microscopic emphysema, pulmonary microvascular disease, ventilatory and gas exchange inefficiency, and left ventricular diastolic dysfunction. Using an integrative physiological approach, the present review summarizes the recent advances in knowledge on the effects of smoking on the lung-heart-muscle axis under the stress of exercise. Special attention is given to the mechanisms connecting physiological abnormalities such as early cardio-pulmonary derangements, inadequate oxygen delivery and utilization, and generalized bioenergetic disturbances at the muscular level with the negative sensations (sense of heightened muscle effort and breathlessness) that may decrease the tolerance of smokers to physical exercise. A deeper understanding of the systemic effects of smoking in subjects who did not (yet) show evidences of COPD and ischemic heart disease – two devastating smoking related diseases – might prove instrumental to fight their ever-growing burden.

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Section: Introductionmentioning

confidence: 99%

Cardiopulmonary and Muscular Interactions: Potential Implications for Exercise (In)tolerance in Symptomatic Smokers Without Chronic Obstructive Pulmonary Disease

et al. 2019

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“…Merokok dapat menyebabkan atau berkontribusi pada timbul dan berkembangnya berbagai penyakit paru-paru (misalnya COPD, fibrosis paru, TBC, dan kanker paru) dan penyakit diluar sistem pernapasan (seperti hipertensi, aritmia, penyakit jantung). Dan sebagian pasien dengan penyakit diatas datang dengan dispnea sebagai gejala utama sebelum diagnosis ditegakkan (Clini et al, 2016).…”

Section: Faktorunclassified

Hubungan Lama Paparan Polusi Udara Dan Perilaku Merokok Terha¬dap Fungsi Paru Pada Driver Ojek Online

Monica

Suwarno

Hidayah

2021

JMN

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Increasing levels of air pollution in Jakarta will have serious health impacts for those exposed, such as online motorcycle taxi drivers. Smoking behavior by online motorcycle taxi drivers can also cause health problems in the form of decreased lung function. This research aimed to figure the relationship between duration of exposure to air pollution and smoking behavior to lung function in online motorcycle taxi drivers at Jakarta. This research used a descriptive correlation design with cross-sectional approach which conducted in June-July 2020. There were 106 online motorcycle taxi drivers selected using accidental sampling technique. Lung function measured using the mMRC dyspnoe scale and distributed using google form. The results of this study found that the mostly 97,7% online motorcycle taxi drivers worked > 40 hours/ week, 68,9% online motorcycle taxi drivers categorized of mild smoking, 60,4% online motorcycle taxi drivers had no dyspnea symptoms (grade 0). Statistical analysis using chi-square showed that there is a significant relationship between smoking behavior with lung function (p-value 0,001), however, there is no significant relationship between duration of exposure to air pollution with lung function (p-value 0,056). It’s expected that online motorcycle taxi drivers can use masks while working to reduce exposure to air pollution and lesser to quit smoking.

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What is the origin of dyspnoea in smokers without airway disease?

Cited by 2 publications

References 21 publications

Cardiopulmonary and Muscular Interactions: Potential Implications for Exercise (In)tolerance in Symptomatic Smokers Without Chronic Obstructive Pulmonary Disease

Cardiopulmonary and Muscular Interactions: Potential Implications for Exercise (In)tolerance in Symptomatic Smokers Without Chronic Obstructive Pulmonary Disease

Hubungan Lama Paparan Polusi Udara Dan Perilaku Merokok Terha¬dap Fungsi Paru Pada Driver Ojek Online

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