What Is the Prevalence of Clinically Significant Endoscopic Findings in Subjects With Dyspepsia? Systematic Review and Meta-analysis

ACG and CAG Clinical Guideline: Management of Dyspepsia

“…Th e quality of evidence is low as there is no study evaluating undiagnosed dyspepsia. Th e results are therefore indirectly applied to this population with the assumption that most dyspepsia patients in North America will have FD ( 73 ). TCAs are unlikely to have a major impact on peptic ulcer disease or gastro-esophageal refl ux disease and so their effi cacy in the general dyspepsia population is likely to be lower than estimated in the systematic review.…”

Functional Dyspepsia

“…In most cases, the cause can be clarified by means of upper gastrointestinal endoscopy, a test that generally shows that less than 10% of patients with dyspepsia have a peptic ulcer, less than 1% have gastroesophageal cancer, and more than 70% have functional dyspepsia. 8 Celiac disease is the great mimic of many gastrointestinal disorders, but its frequency is not significantly increased among persons who report dyspepsia. 9 The patient's medication history should be reviewed, but medication is not usually implicated in causing the dyspepsia.…”

The Rome III Criteria for the Diagnosis of Functional Dyspepsia in Secondary Care Are Not Superior to Previous Definitions

“…13,14 The cost of managing dyspepsia may be reduced if upper GI symptoms could accurately distinguish between organic and functional dyspepsia (FD), but a systematic review has suggested that symptoms perform poorly in this regard. 15 The commonest organic finding at upper GI endoscopy in Western populations with dyspepsia is erosive esophagitis, 16 and over the last 20 years definitions of the condition have been refined substantially, [17][18][19][20] with the main aim of excluding patients with gastro-esophageal reflux disease (GERD), in an attempt to enrich the number of patients with FD.…”