2019
DOI: 10.1016/j.lfs.2019.04.042
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What is the role of peptide fragments of collagen I and IV in health and disease?

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Cited by 121 publications
(86 citation statements)
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“…These findings indicate that DCF absolute induces type I and type IV collagen synthesis in fibroblasts, but not in keratinocytes. It has been reported that type I collagen is a component of interstitial matrix and that type IV collagen synthesis promotes skin basement membrane formation [15,33]. In addition, the syntheses of type I and IV collagens have been associated with wound healing and skin regeneration [8,15].…”
Section: Resultsmentioning
confidence: 99%
“…These findings indicate that DCF absolute induces type I and type IV collagen synthesis in fibroblasts, but not in keratinocytes. It has been reported that type I collagen is a component of interstitial matrix and that type IV collagen synthesis promotes skin basement membrane formation [15,33]. In addition, the syntheses of type I and IV collagens have been associated with wound healing and skin regeneration [8,15].…”
Section: Resultsmentioning
confidence: 99%
“…They generate contractility by cyclic calcium fluxes [17,18]. Fibroblasts secrete collagen precursors and matrix metalloproteinases (MMPs) and thereby actively remodel the ECM [17][18][19]. The ECM embeds the myocytes and non-myocytes.…”
Section: Left-ventricular Hypertrophy In Ckdmentioning
confidence: 99%
“…The ECM embeds the myocytes and non-myocytes. Collagen is the most abundant protein here [19]. These structural changes are closely related to a functional impairment of the left ventricle causing diastolic dysfunction [20] while systolic function may, at least initially, remain normal [21].…”
Section: Left-ventricular Hypertrophy In Ckdmentioning
confidence: 99%
“…Wound repair is a complex process that is broadly categorized into the following four phases which occur in a temporal sequence but are overlapping: hemostasis, inflammation, proliferation (cellular infiltration, angiogenesis and re-epithelialization) and maturation/remodeling ( Figure 1 ) [ 1 ]. Key steps of the wound healing process, such as hemostasis, inflammation and angiogenesis are responsive to the ECM, collagen and its compounds [ 1 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. In response to injury, collagen induces platelet activation and aggregation resulting in the deposition of a fibrin clot at the injury site.…”
Section: Introductionmentioning
confidence: 99%