What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

Berridge, Kent; Robinson, Terry E.

doi:10.1016/s0165-0173(98)00019-8

Cited by 3,578 publications

(2,872 citation statements)

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“…A deficiency of mesolimbic dopaminergic pathway plays a critical role for the etiology of symptoms of depression like anhedonia and decreased motivation (Willner, 1983b;Schultz, 1997;Berridge and Robinson, 1998;Naranjo et al, 2001). Mesolimbic dopamine projections are a crucial component in the neural circuitry of reward and/or incentive motivation, both dysfunctional in major depression disorder (Fibiger, 1995;Naranjo et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Dopamine is also proposed to play an important role in the pathophysiology of depression as well as in the mechanism of action of antidepressant drugs (Willner, 1983a, b;Borsini et al, 1985a, b;Pulvirenti and Samanin, 1986;Fibiger, 1995;Charney, 1998;Naranjo et al, 2001;Klimek et al, 2002;Pania and Gessab, 2002). Mesolimbic dopamine pathways are involved in the control of motivation and reward-related behaviors (Koob, 1996;Robbins and Everitt, 1996;Schultz, 1997;Berridge and Robinson, 1998) and hypofunction of the dopamine system is implicated in the loss of motivation and/or anhedonia described as core symptoms in human depressive states (Nelson and Charney, 1981). Administration of dopamine receptor antagonists, or drugs that reduce dopamine levels such as reserpine, induces dysphoria and many symptoms resembling those of endogenous depression (Wise et al, 1978;Willner, 1983a).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

Basso

Gallagher

Bratcher

et al. 2005

Neuropsychopharmacol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

Basso

Gallagher

Bratcher

et al. 2005

Neuropsychopharmacol

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“…This has consequences for learning accounts of addiction as some learning tendencies appear to confer vulnerability towards developing addiction. In this part, we first present the data on individual differences in Pavlovian responding in some detail (mainly reiterating the findings of Flagel et al 2011b), then discuss its interpretation in terms of incentive salience (Berridge and Robinson, 1998;Berridge, 2004Berridge, , 2007Saunders and Robinson, 2012), and finally put forth a hypothesis that proposes a connection between the propensity to assign incentive salience and the propensity to employ model-free learning (McClure et al, 2003a;Huys et al, 2013b;Lesaint et al, 2013;Dayan and Berridge, 2013).…”

Section: Individual Variabilitymentioning

confidence: 99%

The role of learning-related dopamine signals in addiction vulnerability

Huys

Tobler

Hasler

et al. 2014

Progress in Brain Research

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Psychostimulants such as methylphenidate (MPH) and antidepressants such as fluoxetine (FLX) are widely used in the treatment of various mental disorders or as cognitive enhancers. These medications are often combined, for example, to treat comorbid disorders. There is a considerable body of evidence from animal models indicating that individually these psychotropic medications can have detrimental effects on the brain and behavior, especially when given during sensitive periods of brain development. However, almost no studies investigate possible interactions between these drugs. This is surprising given that their combined neurochemical effects (enhanced dopamine and serotonin neurotransmission) mimic some effects of illicit drugs such as cocaine and amphetamine. Here, we summarize recent studies in juvenile rats on the molecular effects in the mid-and forebrain and associated behavioral changes, after such combination treatments. Our findings indicate that these combined MPH + FLX treatments can produce similar molecular changes as seen after cocaine exposure while inducing behavioral changes indicative of dysregulated mood and motivation, effects that often endure into adulthood. Tables: 2 References: 254 ABSTRACT Dopaminergic signals play a mathematically precise role in reward-related learning, and variations in dopaminergic signalling have been implicated in vulnerability to addiction. Here, we provide a detailed overview of the relationship between theoretical, mathematical and experimental accounts of phasic dopamine signalling, with implications for the role of learning-related dopamine signalling in addiction and related disorders. We describe the theoretical and behavioural characteristics of model-free learning based on errors in the prediction of reward, including step-by-step explanations of the underlying equations. We then use recent insights from an animal model that highlights individual variation in learning during a Pavlovian conditioning paradigm to describe overlapping aspects of incentive salience attribution and model-free learning. We argue that this provides a computationally coherent account of some features of addiction. CONTENTS

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“…Drugs that facilitate DA transmission within the mesolimbic pathway enhance the processes by which otherwise neutral stimuli acquire incentive salience and motivate further drug-seeking behavior (Berridge and Robinson, 1998;Wyvell and Berridge, 2000). Both natural rewards and addictive drugs initially stimulate the release of DA from the mesolimbic pathway.…”

Section: Mesostriatal Acetylcholine and Reward Mediationmentioning

confidence: 99%

The Role of Acetylcholine in Cocaine Addiction

Williams

Adinoff²

2007

Neuropsychopharmacol

163

138

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Central nervous system cholinergic neurons arise from several discrete sources, project to multiple brain regions, and exert specific effects on reward, learning, and memory. These processes are critical for the development and persistence of addictive disorders. Although other neurotransmitters, including dopamine, glutamate, and serotonin, have been the primary focus of drug research to date, a growing preclinical literature reveals a critical role of acetylcholine (ACh) in the experience and progression of drug use. This review will present and integrate the findings regarding the role of ACh in drug dependence, with a primary focus on cocaine and the muscarinic ACh system. Mesostriatal ACh appears to mediate reinforcement through its effect on reward, satiation, and aversion, and chronic cocaine administration produces neuroadaptive changes in the striatum. ACh is further involved in the acquisition of conditional associations that underlie cocaine self-administration and context-dependent sensitization, the acquisition of associations in conditioned learning, and drug procurement through its effects on arousal and attention. Long-term cocaine use may induce neuronal alterations in the brain that affect the ACh system and impair executive function, possibly contributing to the disruptions in decision making that characterize this population. These primarily preclinical studies suggest that ACh exerts a myriad of effects on the addictive process and that persistent changes to the ACh system following chronic drug use may exacerbate the risk of relapse during recovery. Ultimately, ACh modulation may be a potential target for pharmacological treatment interventions in cocaine-addicted subjects. However, the complicated neurocircuitry of the cholinergic system, the multiple ACh receptor subtypes, the confluence of excitatory and inhibitory ACh inputs, and the unique properties of the striatal cholinergic interneurons suggest that a precise target of cholinergic manipulation will be required to impact substance use in the clinical population.

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What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

Cited by 3,578 publications

References 440 publications

Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

The role of learning-related dopamine signals in addiction vulnerability

The Role of Acetylcholine in Cocaine Addiction

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