What's New in Point-of-Care Testing?

Ransohoff, Jaime R; Melanson, Stacy E.F.

doi:10.1097/poc.0000000000000193

Cited by 3 publications

(3 citation statements)

References 70 publications

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“…The outlook of using mini-MS in clinical fields is closely related to the point-of-care system. As briefly mentioned earlier, the point-of-care system is promising to enhance patient care, diagnosis, and management (117). Eventually, on-site diagnosis or nonlaboratory-based analysis is the goal of the point-of-care system.…”

Section: Miniature Mass Spectrometersmentioning

confidence: 99%

Clinical Chemistry for Developing Countries: Mass Spectrometry

Lee

Chintalapudi

Badu‐Tawiah

2021

Annual Rev. Anal. Chem.

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Early disease diagnosis is necessary to enable timely interventions. Implementation of this vital task in the developing world is challenging owing to limited resources. Diagnostic approaches developed for resource-limited settings have often involved colorimetric tests (based on immunoassays) due to their low cost. Unfortunately, the performance/sensitivity of such simplistic tests are often limited and significantly hinder opportunities for early disease detection. A new criterion for selecting diagnostic tests in low- and middle-income countries is proposed here that is based on performance-to-cost ratio. For example, modern mass spectrometry (MS) now involves analysis of the native sample in the open laboratory environment, enabling applications in many fields, including clinical research, forensic science, environmental analysis, and agriculture. In this critical review, we summarize recent developments in chemistry that enable MS to be applied effectively in developing countries. In particular, we argue that closed automated analytical systems may not offer the analytical flexibility needed in resource-limited settings. Alternative strategies proposed here have potential to be widely accepted in low- and middle-income countries through the utilization of the open-source ambient MS platform that enables microsampling techniques such as dried blood spot to be coupled with miniature mass spectrometers in a centralized analytical platform. Consequently, costs associated with sample handling and maintenance can be reduced by >50% of the total ownership cost, permitting analytical measurements to be operated at high performance-to-cost ratios in the developing world. Expected final online publication date for the Annual Review of Analytical Chemistry, Volume 14 is August 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Section: Miniature Mass Spectrometersmentioning

confidence: 99%

Clinical Chemistry for Developing Countries: Mass Spectrometry

Lee

Chintalapudi

Badu‐Tawiah

2021

Annual Rev. Anal. Chem.

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“…5 POCT, geri dönüş süresini iyileştirme, kullanılan tanı yönteminin verimliliğini artırma, kırsal ve gelişmemiş topluluklarda hastalıkların tanılanmasını kolaylaştırma, uzay ve vahşi yaşam gibi ulaşımın zor olduğu alanlarda sağlık hizmetlerini geliştirme potansiyeline sahiptir. 7 POCT küresel sağlık bakım programlarında, özellikle hızlı tıbbi kararların gerekli olduğu ideal olmayan koşullarda değerlidir. Örneğin bir kişi felç geçiriyorsa, sağlık çalışanları felç gerekli ilaçları vermeden önce kan pıhtılaşmasını test etmek için protrombin zamanı/uluslararası normalleştirilmiş oran ölçmelidir.…”

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Point of Care Tests in Healthcare: Traditional Review

BİLMEZ,

İŞBİLİR,

TOPKAYA

2024

J Lit Pharm Sci

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“…Point-of-care testing is increasingly used in a variety of settings because of its potential to provide testing in the absence of a central laboratory, speed up clinical decision-making, reduce iatrogenic blood loss, and increase patient and clinician satisfaction. [2][3][4][5] As is true of laboratory testing, errors that are made while performing POCT may lead to medical adverse events or near misses. 3,[6][7][8] Risk-mitigation strategies to reduce or eliminate such errors include securing point-of-care systems and operations, ensuring data integrity and confidentiality, implementing and enforcing regular quality checks, and POCT oversight by laboratory professionals.…”

mentioning

confidence: 99%

Point-of-Care Testing Practices, Failure Modes, and Risk-Mitigation Strategies in Emergency Medical Services Programs in the Canadian Province of Alberta

Füzéry

Kost

2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Emergency medical services (EMS) programs have been using point-of-care testing (POCT) for more than 20 years. However, only a handful of reports have been published in all of that time on POCT practices in field settings. Objective.— To provide an overview of POCT practices and failure modes in 3 of Alberta's EMS programs, and to propose risk-mitigation strategies for reducing or eliminating these failure modes. Design.— Details about POCT practices, failure modes, and risk-mitigation strategies were gathered through (1) conversations with personnel, (2) in-person tours of EMS bases, (3) accompaniment of EMS personnel on missions, (4) internet searches for publicly available information, and (5) a review of laboratory documents. Results.— Practices were most standardized and robust in the community paramedicine program (single service provider, full laboratory oversight), and least standardized and robust in the air ambulance program (4 service providers, limited laboratory oversight). Common failure modes across all 3 programs included device inoperability due to cold weather, analytical validation procedures that failed to consider the unique challenges of EMS settings, and a lack of real-time electronic transmission of results into the health care record. Conclusions.— A provincial framework for POCT in EMS programs is desirable. Such a framework should include appropriate funding models, laboratory oversight of POCT, and relevant expertise on POCT in EMS settings. The framework should also incorporate specific guidance on quality standards that are needed to address the unique challenges of performing POCT in field settings.

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What's New in Point-of-Care Testing?

Cited by 3 publications

References 70 publications

Clinical Chemistry for Developing Countries: Mass Spectrometry

Clinical Chemistry for Developing Countries: Mass Spectrometry

Point of Care Tests in Healthcare: Traditional Review

Point-of-Care Testing Practices, Failure Modes, and Risk-Mitigation Strategies in Emergency Medical Services Programs in the Canadian Province of Alberta

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