What’s new on primary Hodgkin’s lymphoma of the breast? A case report and review of the literature

Abstract

HighlightsA subtle case report of primary Hodgkin’s disease of the breast.Definition and staging of primary lymphomas of the breast.A comprehensive review of the Literature about this kind of disease.

Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment

“…Furthermore, keratin positivity in a breast FNA showing large malignant cells among abundant lymphoid population can confirm the diagnosis of medullary carcinoma, which may pause diagnostic difficulties. Histological study, which followed, confirmed the unexpected cytological diagnosis, reporting a classical HL of nodular sclerosis subtype, commonly observed involving the breast [4, 5, 12, 14, 15, 17, 20, 22].…”

“…Breast is an uncommon site affected by HL. According to a recent review, 19 cases of primary HL of the breast have been reported since the first description by Kueckens in 1928 [4, 11]. However, after a better search of the literature, we retrieved 5 additional cases [12–16].…”

“…A recent review states that breast HL cannot be diagnosed by FNA. This can be attributed mainly to inadequate or inconclusive material, particularly in cases of nodular sclerosis with abundant collagenous stroma [4]. In another case, cytology was reported as suspicious for malignancy [17].…”

“…Breast is an uncommon site of extranodal Hodgkin lymphoma (HL). Given that only sporadic cases of breast HL have been reported in the literature, the exact prevalence, either as a primary tumor or in the process of disseminated or recurrent disease, cannot be defined [4, 5].…”

Large single cutaneous metastasis of colon adenocarcinoma mimicking a squamous cell carcinoma of the skin: A case report

“…Skin cancer be expression either of a primary disease or of a secondary disease, in which the infiltration is due to a systemic disease or a disease recurrence [ 11 ].…”