What's Your Diagnosis? Well-Demarcated Vulvar Erythema in Two Girls

Trager, Jonathan D.K.

doi:10.1016/j.jpag.2004.11.009

Cited by 9 publications

(17 citation statements)

References 6 publications

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“…Since these agents may cause irritation of the sensitive genital skin, they are usually prescribed in combination with topical corticosteroids, rather than in monotherapy [29]. Also topical treatment with immunomodulators, pimecrolimus ointment or tacrolimus cream, was recommended in monotherapy or in combination with weak corticosteroids [30][31][32]. However, it should be remembered that besides irritation, the immunomodulating agents may promote allergic dermatitis, candidiasis and (re)activation of viral infections [11].…”

Section: Treatmentmentioning

confidence: 99%

Genital psoriasis: a hidden multidisciplinary problem — a review of literature

et al. 2016

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Genital psoriasis is a variety of autoimmune dermatological disease -psoriasis with relapsing-remitting course, which can have an onset in all age groups. It is most often diagnosed at an advanced stage. Genital psoriasis is considered an embarrassing condition and is often misjudged as a sexually transmitted disease or allergic reaction due to low social awareness of the disease. The manifestations of genital psoriasis may differ from typical genital dermatoses and with symptoms such as itch, erythroderma and vaginal discharge may mimic other diseases at an early stage. The diagnosis and treatment of genital psoriasis may be difficult and often requires a multidisciplinary approach. The aim of this article is to present the literature review of genital psoriasis concentrating on the clinical presentation, treatment and influence on the quality of patients' life and sexual activity disorders.

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Section: Treatmentmentioning

confidence: 99%

Genital psoriasis: a hidden multidisciplinary problem — a review of literature

et al. 2016

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“…Psoriatic lesions on the genital skin often present as well-demarcated, brightly erythematous, thin plaques and usually lack, due to maceration, the typical scaling that is apparent on other parts of the body (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39). However, scales may be seen on the more keratinised regions of the genital skin (34,40,41).…”

Section: Clinical Presentation [Loe: 5]mentioning

confidence: 99%

“…When scaling is present, it is often minimal and can easily be scraped off, leaving pinpoint bleedings (26,27,38,42). The appearance of vulvar psoriasis is often symmetrical and can vary from silvery, scaling patches adjacent to the outer parts of the labia majora to moist greyish plaques or glossy red plaques without scaling in the skin folds (33,35,40,(42)(43)(44)(45).…”

Section: Clinical Presentation [Loe: 5]mentioning

confidence: 99%

“…Despite these positive opinions regarding the use of coal-tar preparations, there are also reports that advise against the use of tar preparations because of their potential to cause irritation (22,29,32,33). Others point out the importance of the choice of the vehicle, as tar gels may be too irritating to sensitive genital skin and tar ointment may cause folliculitis in hairy areas.…”

Section: îmentioning

confidence: 99%

“…Vitamin D analogues may cause irritation, which may be minimised by their combination with steroids (25,46). Nevertheless, some authors advise against the use of vitamin D analogues, as these may be too irritating to apply to the genital area (33,60). Immunomodulators, One author expressed the opinion that the use of pimecrolimus ointment or tacrolimus cream may be useful (33), while acknowledging that they may cause local irritation and stinging.…”

Section: îmentioning

confidence: 99%

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Genital Psoriasis: A Systematic Literature Review on this Hidden Skin Disease

Meeuwis¹,

Hullu²,

Massuger³

et al. 2011

Acta Derm Venerol

147

133

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It is well known that the genital skin may be affected by psoriasis. However, little is known about the prevalence and clinical appearance of genital psoriasis, and genital skin is often neglected in the treatment of psoriatic patients. We performed an extensive systematic literature search for evidence-based data on genital psoriasis with respect to epidemiology, aetiology, clinical and histopathological presentation, diagnosis and treatment. Three bibliographical databases (PubMed, EMBASE and the Cochrane Library) were used as data sources. Fifty-nine articles on genital psoriasis were included. The results show that psoriasis frequently affects the genital skin, but that evidence-based data with respect to the efficacy and safety of treatments for genital psoriasis are extremely limited. An advised treatment paradigm for genital psoriasis, based on the levels of evidence, is: first-line: (weak) topical corticosteroids; second-line: vitamin D preparations or tar-based treatments.

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Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone

Guglielmetti

Conlledo

Bedoya

et al. 2012

Dermatol Ther (Heidelb)

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IntroductionInverse psoriasis is a rare form of psoriasis that affects between 3% and 7% of the patients with psoriasis. It can comprise genital skin folds as part of genital psoriasis, and it is one of the most commonly seen dermatoses of this area. There are few evidence-based studies about the treatment of intertriginous psoriasis involving genital skin folds.Case PresentationThe authors present a 42-year-old female patient with erythematous plaques in the vulva, groin, and perianal region. The patient had previously received a broad range of topical and systemic therapies that had to be discontinued due to ineffectiveness or side effects. She was treated with 100 mg dapsone daily for 10 months, showing a significant improvement of her cutaneous and mucous lesions. Complete clearance of psoriatic lesions was observed after 4 weeks of treatment. She has remained in remission for up to 2 years, using only topical therapy with tacrolimus 0.1% and calcipotriol.DiscussionGenital psoriasis is a skin disease that causes great discomfort. It is important to include examination of the genital region and to adopt this conduct in daily clinical practice. Research in this field is still poor, making no discrimination between flexural and genital psoriasis, and is based on case series and expert opinion; therefore, empirical recommendations for the treatment of genital psoriasis remain. Dapsone has been shown to be an effective and convenient alternative for the treatment of inverse psoriasis in genital skin folds, which can provide effective control of the disease. Further studies are required to determine the efficacy and safety of current therapies, and to decide whether dapsone therapy should be considered in the management of this form of psoriasis when topical and other systemic agents are not effective.

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What's Your Diagnosis? Well-Demarcated Vulvar Erythema in Two Girls

Cited by 9 publications

References 6 publications

Genital psoriasis: a hidden multidisciplinary problem — a review of literature

Genital psoriasis: a hidden multidisciplinary problem — a review of literature

Genital Psoriasis: A Systematic Literature Review on this Hidden Skin Disease

Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone

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