What Tinnitus Therapy Outcome Measures Are Important for Patients?– A Discrete Choice Experiment

Rademaker, Maaike M.; Essers, Brigitte; Stokroos, Robert J.; Smit, A.L.; Stegeman, Inge

doi:10.3389/fneur.2021.668880

Cited by 8 publications

(4 citation statements)

References 37 publications

(50 reference statements)

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“…In summary, the effects of the combined treatment are stronger for the tinnitus loudness than for tinnitus distress, which is probably in favor for the tinnitus sufferers since a recent analysis by Rademaker et al 2021 [22] concluded that tinnitus patients consider loudness the most important outcome measure. With this study, we can only document the changes of tinnitus loudness and distress but cannot identify the underlying therapeutic mechanism.…”

Section: Discussionmentioning

confidence: 96%

Auricular Acupressure Combined with Self-Help Intervention for Treating Chronic Tinnitus: A Longitudinal Observational Study

Schlee¹,

Simões²,

Pryss³

2021

Preprint

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Tinnitus is a phantom sound perception in the ears or head and can arise from many different medical disorders. Currently, there is no standard treatment for tinnitus that reliably reduces tinnitus. Individual patients reported that acupressure at various points around the ear can help to reduce tinnitus, which was investigated here. With this longitudinal observational study, we report a systematic evaluation of auricular acupressure on 39 tinnitus sufferers, combined with a self-help smartphone app. The participants were asked to report about tinnitus, stress, mood, neck and jaw muscle tensions twice a day using an ecological momentary assessment study design for six weeks. On average, 123.6 questionnaires per person were provided and used for statistical analysis. The treatment responses of the participants were heterogeneous. On average, we ob-served significant negative trends for tinnitus loudness (Cohen’s d effect size: -.861), tinnitus dis-tress (d = -.478), stress (d = -.675), and tensions in the neck muscles (d = -.356). Comparison with a matched control group revealed significant improvements for tinnitus loudness (p = .027) and self-reported stress level (p = .003). The positive results of the observational study motivate fur-ther research including a randomized clinical trial and long-term assessment of the clinical im-provement.

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Section: Discussionmentioning

confidence: 96%

Auricular Acupressure Combined with Self-Help Intervention for Treating Chronic Tinnitus: A Longitudinal Observational Study

Schlee¹,

Simões²,

Pryss³

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…In summary, the effects of the combined treatment are stronger for the tinnitus loudness than for tinnitus distress, which is probably in favor for the tinnitus sufferers since a recent analysis by Rademaker et al 2021 [ 23 ] concluded that tinnitus patients consider loudness the most important outcome measure. With this study, we can only document the changes of tinnitus loudness and distress but cannot identify the underlying therapeutic mechanism.…”

Section: Discussionmentioning

confidence: 98%

Auricular Acupressure Combined with Self-Help Intervention for Treating Chronic Tinnitus: A Longitudinal Observational Study

Schlee

Simões

Pryss

2021

JCM

View full text Add to dashboard Cite

Tinnitus is a phantom sound perception in the ears or head and can arise from many different medical disorders. Currently, there is no standard treatment for tinnitus that reliably reduces tinnitus. Individual patients reported that acupressure at various points around the ear can help to reduce tinnitus, which was investigated here. With this longitudinal observational study, we report a systematic evaluation of auricular acupressure on 39 tinnitus sufferers, combined with a self-help smartphone app. The participants were asked to report on tinnitus, stress, mood, neck, and jaw muscle tensions twice a day using an ecological momentary assessment study design for six weeks. On average, 123.6 questionnaires per person were provided and used for statistical analysis. The treatment responses of the participants were heterogeneous. On average, we observed significant negative trends for tinnitus loudness (Cohen’s d effect size: −0.861), tinnitus distress (d = −0.478), stress (d = −0.675), and tensions in the neck muscles (d = −0.356). Comparison with a matched control group revealed significant improvements for tinnitus loudness (p = 0.027) and self-reported stress level (p = 0.003). The positive results of the observational study motivate further research including a randomized clinical trial and long-term assessment of the clinical improvement.

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“…The secondary outcome is the prediction model of the effect of electrical stimulation on tinnitus impact (or synonyms) measured by multi-item tinnitus questionnaires or single-item VAS scores of acceptance, annoyance, awareness, intrusiveness, unpleasantness 31 or loudness. 32 …”

Section: Methodsmentioning

confidence: 99%

Effect of electrical stimulation with a cochlear implant on tinnitus impact: protocol of an individual patient data meta-analysis

2022

Self Cite

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IntroductionTinnitus is the perception of sound without an external stimulus, often experienced as a ringing, buzzing sound. While several studies have shown a reduction in tinnitus distress following cochlear implantation, others showed an increase or no change after implantation. At this stage, clinicians have little certainty when counselling their patients prior to implantation regarding tinnitus post-implantation. To help clinicians to counsel cochlear implant (CI) candidates on the risk of developing or improving tinnitus after implantation, we aim to assess the effect of electrical stimulation with a CI on tinnitus impact for individual adult patients with tinnitus. We will also apply prediction models to individual patient data (IPD) of clinical trials to find predictive factors of the effect of electrical stimulation on tinnitus impact.Method and analysisThe IPD meta-analysis is a follow-up project of the systematic review on cochlear implantation in patients with tinnitus as a primary complaint. First, the systematic searches will be updated to date. Methodological quality of eligible studies will be assessed using the Risk of Bias In Non-randomised Studies of Intervention tool (ROBINS-I). Based on a data-sharing agreement, authors of the eligible studies will be invited to share their deidentified and complete IPD. The primary outcome is the effect of electrical stimulation with a CI on tinnitus impact 1 month or more post-implantation. IPD meta-analysis will be used to assess the primary outcome, while differentiating the tinnitus impact questionnaires. Second, linear regression analyses will be used to model the effect of electrical stimulation on tinnitus impact based on relevant predictors.Ethics and disseminationThe Medical Research Involving Human Subject Act does not apply, and ethical approval is not required. The study results will be made accessible to the public in a peer-review open access journal.PROSPERO registration numberCRD42022319367, review ongoing.

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What Tinnitus Therapy Outcome Measures Are Important for Patients?– A Discrete Choice Experiment

Cited by 8 publications

References 37 publications

Auricular Acupressure Combined with Self-Help Intervention for Treating Chronic Tinnitus: A Longitudinal Observational Study

Auricular Acupressure Combined with Self-Help Intervention for Treating Chronic Tinnitus: A Longitudinal Observational Study

Auricular Acupressure Combined with Self-Help Intervention for Treating Chronic Tinnitus: A Longitudinal Observational Study

Effect of electrical stimulation with a cochlear implant on tinnitus impact: protocol of an individual patient data meta-analysis

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