What Was the Patient's Occupation?

Descatha, Alexis; Deschamps, Emmanuelle

doi:10.1097/rhu.0b013e3181d59d46

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Bernard and colleagues [24] reported that stair climbing was associated with foot OA. Descatha and Deschamps [51] reported the case of a 55-year old woman suffering from pains in the feet. Over 40 years as a professional dancer and dance teacher caused localized OA of the tarsometatarsal joint, or at least accelerated the degenerative process.…”

Section: Occupational Risk Factors For Osteoarthritismentioning

confidence: 99%

Occupational and genetic risk factors for osteoarthritis: A review

Yücesoy

Charles

Baker

et al. 2015

Work

137

111

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BACKGROUND Osteoarthritis (OA) is a multifactorial disease with strong genetic and occupational components. Although published studies have described several risk factors for OA, very few studies have investigated the occupational and genetic factors that contribute to this debilitating condition. OBJECTIVE To describe occupational and genetic factors that may contribute to the risk of developing (OA). METHODS A literature search was conducted in PubMed using the search terms osteoarthritis, occupation, work, and genetics. RESULTS Heavy physical work load was the most common occupational risk factor for OA in several anatomical locations. Other factors include kneeling and regular stair climbing, crawling, bending and whole body vibration, and repetitive movements. Numerous studies have also shown the influence of genetic variability in the pathogenesis of OA. Genetic variants of several groups of genes e.g., cartilage extracellular matrix structural genes and the genes related to bone density have been implicated in disease pathogenesis. CONCLUSION This review shows that occupational factors were extensively studied in knee OA unlike OA of other anatomical regions. Although genetic association studies performed to date identified a number of risk variants, some of these associations have not been consistently replicated across different studies and populations. Therefore, more research is needed.

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Section: Occupational Risk Factors For Osteoarthritismentioning

confidence: 99%

Occupational and genetic risk factors for osteoarthritis: A review

Yücesoy

Charles

Baker

et al. 2015

Work

137

111

View full text Add to dashboard Cite

show abstract

“…lower educational attainment, and (a history of) physically demanding occupation (e.g. frequent stair climbing, professional dance) appear to contribute more to the risk of MTP1 clinical or radiographic OA in the general population, and primary OA [52,74,73,75], and we therefore assume that the combination of biomechanical factors, including acromegaly-related physical changes (e.g. feet enlargement, joint misalignment), contribute most to the development of MTP1 OA in acromegaly.…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiographic assessment of peripheral joints in controlled acromegaly

Pelsma

Kroon

Trigt

et al. 2022

Preprint

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PurposeAcromegalic arthropathy is a well-known phenomenon, occurring in most patients regardless of disease status. To date, solely hips, knees, hands, and spinal joints have been radiographically assessed. Therefore, this study aimed to assess the prevalence of joint symptoms and radiographic osteoarthritis (OA) of new, and established peripheral joint sites in well-controlled acromegaly. MethodsFifty-one acromegaly patients (56% female, mean age 64±12years) in long-term remission for 18.3 years (median, IQR 7.2 – 25.4) were included. Nineteen patients currently received pharmacological treatment. Self-reported joint complaints were assessed using standardized interviews. Self-reported disability of the upper and lower limbs, and health-related quality of life (HR-QoL) were evaluated using validated questionnaires. Radiographic OA (defined as KL≥2) was scored using (modified) Kellgren&Lawrence (KL) methods. ResultsRadiographic signs of OA were present in 46 patients (90.2%), which occurred in a generalized manner in virtually all patients (N=44; 95.7%). Radiographic MTP1 OA was as prevalent as radiographic knee OA (N=26, 51.0%), and radiographic glenohumeral OA was similarly prevalent as hip OA (N=21 (41.2%) vs N=24 (47.1%)). Risk factors for radiographic glenohumeral OA were higher pre-treatment IGF-1 levels (OR 1.06 (1.01 – 1.12), P=0.021), and current pharmacological treatment (OR 5.01 (1.03 – 24.54), P=0.047), whereas no risk factors for MTP1 joint OA could be identified.ConclusionSimilar to previously-assessed peripheral joints, clinical and radiographic arthropathy of the shoulder and feet were prevalent in controlled acromegaly. Further studies on adequate management strategies of acromegalic arthropathy are needed.

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“…lower educational attainment, and (a history of) physically demanding occupation (e.g. frequent stair climbing, professional dance) appear to contribute more to the risk of MTP1 clinical or radiographic OA in the general population, and primary OA [ 54 , 75 – 77 ], and we therefore assume that the combination of biomechanical factors, including acromegaly-related physical changes (e.g. feet enlargement, joint misalignment), contribute most to the development of MTP1 OA in acromegaly.…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiographic assessment of peripheral joints in controlled acromegaly

et al. 2022

View full text Add to dashboard Cite

Purpose Acromegalic arthropathy is a well-known phenomenon, occurring in most patients regardless of disease status. To date, solely hips, knees, hands, and spinal joints have been radiographically assessed. Therefore, this study aimed to assess the prevalence of joint symptoms and radiographic osteoarthritis (OA) of new, and established peripheral joint sites in well-controlled acromegaly. Methods Fifty-one acromegaly patients (56% female, mean age 64 ± 12 years) in long-term remission for 18.3 years (median, IQR 7.2–25.4) were included. Nineteen patients currently received pharmacological treatment. Self-reported joint complaints were assessed using standardized interviews. Self-reported disability of the upper and lower limbs, and health-related quality of life (HR-QoL) were evaluated using validated questionnaires. Radiographic OA [defined as Kellgren & Lawrence (KL) ≥ 2] was scored using (modified) KL methods. Results Radiographic signs of OA were present in 46 patients (90.2%) with ≥ 2 joints affected in virtually all of these patients (N = 44; 95.7%). Radiographic MTP1 OA was as prevalent as radiographic knee OA (N = 26, 51.0%), and radiographic glenohumeral OA was similarly prevalent as hip OA [N = 21 (41.2%) vs. N = 24 (47.1%)]. Risk factors for radiographic glenohumeral OA were higher pre-treatment IGF-1 levels [OR 1.06 (1.01–1.12), P = 0.021], and current pharmacological treatment [OR 5.01 (1.03–24.54), P = 0.047], whereas no risk factors for MTP1 joint OA could be identified. Conclusion Similar to previously-assessed peripheral joints, clinical and radiographic arthropathy of the shoulder and feet were prevalent in controlled acromegaly. Further studies on adequate management strategies of acromegalic arthropathy are needed.

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What Was the Patient's Occupation?

Cited by 3 publications

References 5 publications

Occupational and genetic risk factors for osteoarthritis: A review

Occupational and genetic risk factors for osteoarthritis: A review

Clinical and radiographic assessment of peripheral joints in controlled acromegaly

Clinical and radiographic assessment of peripheral joints in controlled acromegaly

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