What you always wanted to know about gastric MALT-lymphoma: a focus on recent developments

Raderer, Markus; Kiesewetter, Barbara

doi:10.1177/17588359211033825

Cited by 9 publications

(8 citation statements)

References 100 publications

(188 reference statements)

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“…These types are characterised by a greater degree of disease progression. If no spiral bacteria are found on histology, other methods should be used to assess H. pylori infection: serology, faecal H. pylori antigen and urea breath test [ 126 ].…”

Section: Prevention and Public Healthmentioning

confidence: 99%

Diagnostic and therapeutic recommendations on Helicobacter pylori infection. Recommendations of the Working Group of the Polish Society of Gastroenterology

Jaroń,

Pietrzak,

Daniluk

et al. 2023

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Helicobacter pylori remains a major health problem worldwide, causing considerable morbidity and mortality due to peptic ulcer disease and gastric cancer. These guidelines constitute an update of the previous “Recommendations on the diagnosis and management of Helicobacter pylori infection” issued in 2014. They have been developed by a Task Force organized by the Governing Board of the Polish Society of Gastroenterology. They discuss, with particular emphasis on new scientific data covering papers published since 2014: the epidemiology, clinical presentation, diagnostic principles and criteria for the diagnosis, and recommendations for the treatment of H. pylori infection. The guidelines in particular determine which patients need to be tested and treated for infection. The Task Force also discussed recommended treatment algorithms. Accordingly, a combination of available evidence and consensus-based expert opinion were used to develop these best practice advice statements. It is worth noting that guidelines are not mandatory to implement but they offer advice for pragmatic, relevant and achievable diagnostic and treatment pathways based on established key treatment principles and using local knowledge and available resources to guide regional practice.

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Section: Prevention and Public Healthmentioning

confidence: 99%

Diagnostic and therapeutic recommendations on Helicobacter pylori infection. Recommendations of the Working Group of the Polish Society of Gastroenterology

Jaroń,

Pietrzak,

Daniluk

et al. 2023

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“…Immunomodulatory drugs (IMiDs) represent a novel therapeutic approach to target the tumor microenvironment of MALT lymphomas. IMiDs, consisting of thalidomide, lenalidomide and pomalidomide, are approved for the treatment of multiple myeloma, and lenalidomide is approved for the treatment of relapsed follicular lymphoma[ 53 , 68 - 70 ]. IMiDs exert anti-inflammatory effects, such as decreased production of cytokines and increased production of Th1 type cytokines; furthermore, they decrease vascular endothelial growth factor (VEGF) levels and show modulating effects on basic cellular mechanisms (T cell costimulation and alteration of FOXP3+ Tregs and natural killer cells)[ 68 , 69 ].…”

Section: Tumor Microenvironment-targeting Therapiesmentioning

confidence: 99%

“…The efficacy of lenalidomide in MALT lymphomas has been reported in studies with induction of remission after treatment for up to 32 mo[ 71 ]. Raderer and Kiesewetter[ 53 ] conducted a phase II study with a combination therapy consisting of lenalidomide and rituximab, which achieved an overall response rate of 80% and a complete remission rate of 54%.…”

Section: Tumor Microenvironment-targeting Therapiesmentioning

confidence: 99%

“…It has been shown that the Bruton’s kinase inhibitor ibrutinib reduces the number of Tregs in the early course of treatment in chronic lymphocytic leukemia (CLL), in addition to inhibiting the BCR pathway[ 75 ]. Ibrutinib has been tested in relapsed/refractory marginal zone B cell lymphoma (MZL) and possesses a remarkable response rate with tolerable toxicity[ 53 ]. However, no data are available thus far for the treatment of MALT lymphoma.…”

Section: Tumor Microenvironment-targeting Therapiesmentioning

confidence: 99%

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Impact of the microenvironment on the pathogenesis of mucosa-associated lymphoid tissue lymphomas

Uhl¹,

Prochazka²,

Fechter³

et al. 2022

WJGO

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Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphomas of mucosa-associated lymphoid tissue (MALT), also known as MALT lymphomas. These arise at a wide range of different extranodal sites, with most cases affecting the stomach, the lung, the ocular adnexa and the thyroid. The small intestine is involved in a lower percentage of cases. Lymphoma growth in the early stages is associated with long-lasting chronic inflammation provoked by bacterial infections ( e.g ., Helicobacter pylori or Chlamydia psittaci infections) or autoimmune conditions ( e.g ., Sjögren’s syndrome or Hashimoto thyroiditis). While these inflammatory processes trigger lymphoma cell proliferation and/or survival, they also shape the microenvironment. Thus, activated immune cells are actively recruited to the lymphoma, resulting in either direct lymphoma cell stimulation via surface receptor interactions and/or indirect lymphoma cell stimulation via secretion of soluble factors like cytokines. In addition, chronic inflammatory conditions cause the acquisition of genetic alterations resulting in autonomous lymphoma cell growth. Recently, novel agents targeting the microenvironment have been developed and clinically tested in MALT lymphomas as well as other lymphoid malignancies. In this review, we aim to describe the composition of the microenvironment of MALT lymphoma, the interaction of activated immune cells with lymphoma cells and novel therapeutic approaches in MALT lymphomas using immunomodulatory and/or microenvironment-targeting agents.

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“…Gastric MALT lymphoma, has attracted attention because of its relationship with Helicobacter pylori (H. pylori). H. pylori eradication was considered as the first-line treatment regardless of stages and H. pylori status in the latest review (1). As for patients with localized disease who failed response after H. pylori eradication, radiotherapy was suggested, but is there a place for endoscopic treatment in such patients remains open to debate.…”

Section: To the Editormentioning

confidence: 99%

Does endoscopic submucosal dissection have its place in the treatment of patients with gastric mucosa associated lymphoid tissue lymphoma localized disease after eradication?

Wang

Zhang

et al. 2022

AGEB

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Mucosa associated lymphoid tissue (MALT) lym- phoma, one of the B-cell non-Hodgkin’s lymphoma, always occurs in the extranodal margin zone. Gastric MALT lymphoma, has attracted attention because of its relationship with Helicobacter pylori (H. pylori). H. pylori eradication was considered as the first-line treatment regardless of stages and H. pylori status in the latest review (1). As for patients with localized disease who failed response after H. pylori eradication, radiotherapy was suggested, but is there a place for endoscopic treatment in such patients remains open to debate.

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What you always wanted to know about gastric MALT-lymphoma: a focus on recent developments

Cited by 9 publications

References 100 publications

Diagnostic and therapeutic recommendations on Helicobacter pylori infection. Recommendations of the Working Group of the Polish Society of Gastroenterology

Diagnostic and therapeutic recommendations on Helicobacter pylori infection. Recommendations of the Working Group of the Polish Society of Gastroenterology

Impact of the microenvironment on the pathogenesis of mucosa-associated lymphoid tissue lymphomas

Does endoscopic submucosal dissection have its place in the treatment of patients with gastric mucosa associated lymphoid tissue lymphoma localized disease after eradication?

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