Wheel running reduces high-fat diet intake, preference and mu-opioid agonist stimulated intake

Liang, Nu-Chu; Bello, Nicholas T.; Moran, Timothy H.

doi:10.1016/j.bbr.2015.02.004

Cited by 33 publications

(24 citation statements)

References 51 publications

(70 reference statements)

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“…5I) during the 2nd exposure of Experiment 2. These results are consistent with our recent report that wheel running decreases preferences for previously formed preference to a familiar HF diet [26]. Taken together, these data indicate that the decreases in HF diet preference with exercise are not simply due to neophobia or a conditioning learning.…”

Section: Discussionsupporting

confidence: 93%

Wheel running decreases palatable diet preference in Sprague–Dawley rats

Moody

Liang

Choi

et al. 2015

Physiology & Behavior

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Physical activity has beneficial effects on not only improving some disease conditions but also by preventing the development of multiple disorders. Experiments in this study examined the effects of wheel running on intakes of chow and palatable diet e.g. high fat (HF) or high sucrose (HS) diet in male and female Sprague Dawley rats. Experiment 1 demonstrated that acute wheel running results in robust HF or HS diet avoidance in male rats. Although female rats with running wheel access initially showed complete avoidance of the two palatable diets, the avoidance of the HS diet was transient. Experiment 2 demonstrated that male rats developed decreased HF diet preferences regardless of the order of diet and wheel running access presentation. Running associated changes in HF diet preference in females, on the other hand, depended on the testing schedule. In female rats, simultaneous presentation of the HF diet and running access resulted in transient complete HF diet avoidance whereas running experience prior to HF diet access did not affect the high preference for the HF diet. Ovariectomy in females resulted in HF diet preference patterns that were similar to those in male rats during simultaneous exposure of HF and wheel running access but similar to intact females when running occurred before HF exposure. Overall, the results demonstrated wheel running associated changes in palatable diet preferences that were in part sex dependent. Furthermore, ovarian hormones play a role in some of the sex differences. These data reveal complexity in the mechanisms underlying exercise associated changes in palatable diet preference.

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Section: Discussionsupporting

confidence: 93%

Wheel running decreases palatable diet preference in Sprague–Dawley rats

Moody

Liang

Choi

et al. 2015

Physiology & Behavior

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“…Wheel running immediately reduces intake of and preference for a HF diet regardless of its familiarity (23,29). Results of experiment 1 replicated our previous results that wheel running induces reduced intake of a novel HF diet (29) and demonstrated that plasma corticosterone levels were significantly increased and positively correlated with wheel-running activity during the two-diet-choice feeding regimen.…”

Section: Discussionsupporting

confidence: 86%

“…In recent years, a paradigm of wheel running with two-diet choice, chow vs. HF, available simultaneously has been established (23,36). We have used this paradigm to demonstrate that wheel running reduces intake and preference to a previously preferred HF diet (23). When the exposure to the HF diet and wheel-running opportunity occurs simultaneously, the reduced HF diet preference can be so profound that the rats avoid the HF diet and consume only the chow diet (29).…”

mentioning

confidence: 98%

“…The food source in these studies included only a single diet, a standard high-carbohydrate (chow) or a high-fat (HF) diet. In recent years, a paradigm of wheel running with two-diet choice, chow vs. HF, available simultaneously has been established (23,36). We have used this paradigm to demonstrate that wheel running reduces intake and preference to a previously preferred HF diet (23).…”

mentioning

confidence: 99%

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Corticosterone administration in drinking water decreases high-fat diet intake but not preference in male rats

Boersma

Tamashiro

Moran

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

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One of the mechanisms through which regular exercise contributes to weight maintenance could be by reducing intake and preference for high-fat (HF) diets. Indeed, we previously demonstrated that wheel-running rats robustly reduced HF diet intake and preference. The reduced HF diet preference by wheel running can be so profound that the rats consumed only the chow diet and completely avoided the HF diet. Because previous research indicates that exercise activates the hypothalamic-pituitary-adrenal axis and increases circulating levels of corticosterone, this study tested the hypothesis that elevation of circulating corticosterone is involved in wheel running-induced reduction in HF diet preference in rats.Experiment 1 measured plasma corticosterone levels under sedentary and wheel-running conditions in the two-diet-choice (high-carbohydrate chow vs. HF) feeding regimen. The results revealed that plasma corticosterone is significantly increased and positively correlated with the levels of running in wheel-running rats with two-diet choice.Experiments 2 and 3 determined whether elevated corticosterone without wheel running is sufficient to reduce HF diet intake and preference. Corticosterone was elevated by adding it to the drinking water. Compared with controls, corticosterone-drinking rats had reduced HF diet intake and body weight, but the HF diet preference between groups did not differ. The results of this study support a role for elevated corticosterone on the reduced HF diet intake during wheel running. The elevation of corticosterone alone, however, is not sufficient to produce a robust reduction in HF diet preference.

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“…Both μ-opioid receptor 1 (OPRM1) and preproenkephalin (PENK) mRNA in the ventral striatum were increased in RUN females compared to SED females, while there was no change in expression level in males. A previous study also showed no change in nucleus accumbens OPRM1 gene expression profiles in male rats following access to voluntary running wheels and high-fat plus chow diets [46], yet females were not explored.…”

Section: Discussionmentioning

confidence: 99%

Sex determines effect of physical activity on diet preference: Association of striatal opioids and gut microbiota composition

Lee

Muckerman

Wright

et al. 2017

Behavioural Brain Research

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Previous studies suggest an interaction between the level of physical activity and diet preference. However, this relationship has not been well characterized for sex differences that may exist. The present study examined the influence of sex on diet preference in male and female Wistar rats that were housed under either sedentary (no wheel access) (SED) or voluntary wheel running access (RUN) conditions. Following a 1 week acclimation period to these conditions, standard chow was replaced with concurrent ad libitum access to a choice of 3 pelleted diets (high-fat, high-sucrose, and high-corn starch) in the home cage. SED and RUN conditions remained throughout the next 4 week diet preference assessment period. Body weight, running distance, and intake of each diet were measured daily. At the conclusion of the 4 week diet preference test, animals were sacrificed and brains were collected for mRNA analysis. Fecal samples were also collected before and after the 4 week diet preference phase to characterize microbiota composition. Results indicate sex dependent interactions between physical activity and both behavioral and physiological measures. Females in both RUN and SED conditions preferred the high-fat diet, consuming significantly more high-fat diet than either of the other two diets. While male SED rats also preferred the high-fat diet, male RUN rats consumed significantly less high-fat diet than the other groups, instead preferring all three diets equally. There was also a sex dependent influence of physical activity on both reward related opioid mRNA expression in the ventral striatum and the characterization of gut microbiota. The significant sex differences in response to physical activity observed through both behavioral and physiological measures suggest potential motivational or metabolic difference between males and females. The findings highlight the necessity for further exploration between male and female response to physical activity and feeding behavior.

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Wheel running reduces high-fat diet intake, preference and mu-opioid agonist stimulated intake

Cited by 33 publications

References 51 publications

Wheel running decreases palatable diet preference in Sprague–Dawley rats

Wheel running decreases palatable diet preference in Sprague–Dawley rats

Corticosterone administration in drinking water decreases high-fat diet intake but not preference in male rats

Sex determines effect of physical activity on diet preference: Association of striatal opioids and gut microbiota composition

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