1998
DOI: 10.1016/s0002-9378(98)70539-3
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When does estrogen replacement therapy improve sleep quality?

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Cited by 216 publications
(117 citation statements)
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References 19 publications
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“…Whereas there are numerous animal studies and some clinical evidence that hops may contribute to the therapeutic efficacy of certain polyherbal sedative preparations, no randomized, double blind, placebo-controlled clinical trials have been identified that would support the internal use of hops for their estrogenic properties. Considering that sleep disturbances are frequently associated with menopause (Polo-Kantola et al, 1998;PoloKantola et al, 2001), and that hops are not only estrogenic but also used traditionally as a sedative, it is a reasonable hypothesis that properly formulated hop preparations can have a rational place in modern medicine. In order to test this ultimate hypothesis, a dosage form must be produced.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Whereas there are numerous animal studies and some clinical evidence that hops may contribute to the therapeutic efficacy of certain polyherbal sedative preparations, no randomized, double blind, placebo-controlled clinical trials have been identified that would support the internal use of hops for their estrogenic properties. Considering that sleep disturbances are frequently associated with menopause (Polo-Kantola et al, 1998;PoloKantola et al, 2001), and that hops are not only estrogenic but also used traditionally as a sedative, it is a reasonable hypothesis that properly formulated hop preparations can have a rational place in modern medicine. In order to test this ultimate hypothesis, a dosage form must be produced.…”
Section: Discussionmentioning
confidence: 99%
“…Hop preparations continue to be recommended by proponents of herbal medicine for similar indications as in the past (Blumenthal, 2000;Schulz et al, 2001). Sleep disturbances are associated with the climacteric (Polo-Kantola et al, 1998;Polo-Kantola et al, 2001), and it is possible that the sedative properties of hops can benefit people suffering from such complaints. Wilcox noted, "hops lose their active properties on keeping" (Wilcox, 1912), while Youngken asserted that they are "unfit for use in pharmacy when they develop a valeric acid odor" (Youngken, 1950).…”
Section: Sedative Activitymentioning
confidence: 99%
“…Por outro lado, vários autores assinalaram que a nictúria pode levar a distúrbios do sono na pós-menopausa com maior freqüência do que os sintomas vasomotores 20 . Outros estudos sugerem que as mudanças de humor que se verificam na pós-menopausa seriam resultantes de distúrbios no sono decorrentes dos fogachos que ocorrem durante esse período 19,21 .…”
Section: Discussionunclassified
“…Não está claro, porém, na literatura, se essas alterações decorrem do estado hormonal alterado nesse período ou do próprio envelhecimento. Além disso, fatores que ocorrem na pós-menopausa, como ondas de calor [16][17][18][19] , nictúria 19 e alterações de humor 13,[19][20][21] , poderiam ter papel mais relevante nos distúrbios do sono do que o estado hormonal per si.…”
Section: Introductionunclassified
“…Entretanto, se a mulher não refere sintomas de deficiência estrogênica, mas apresenta sintomas emocionais ou físicos, é imprová-vel que ela melhore com a TRH 29,30 . Essas considerações podem, ao menos em parte, explicar a semelhança nos componentes do SF-36 nessa casuística.…”
Section: Discussionunclassified