When is Helicobacter pylori infection acquired?

Cullen, Digby J.; Collins, B. J.; Christiansen, Keryn; Epis, J; Warren, Janet I.; Surveyor, Ivor; Cullen, Kevin J.

doi:10.1136/gut.34.12.1681

Cited by 205 publications

(85 citation statements)

References 6 publications

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“…pylon infection has declined within the past 3 decades. 34,35 In conclusion, the predominance of people with short duration of schooling, lack of vocational training/education, semiskilled and unskilled occupations, and high work-related energy expenditure among those with chronic H. pylon infection could explain the previously reported association between low socioeconomic status andH. pylon infection.…”

mentioning

confidence: 60%

Socioeconomic factors in Helicobacter pylori infection among Danish adults.

Rosenstock

Andersen²,

Rosenstock³

et al. 1996

Am J Public Health

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OBJECTIVES: This study examined the relationship between housing conditions, educational level, occupational factors, and serologically diagnosed acute and chronic Helicobacter pylori infection. METHODS: Immunoglobulin G and immunoglobulin M serum antibodies against H. pylori were measured in 3589 Danish adults who participated in a population study. RESULTS: Low socioeconomic status (odds ratio [OR] = 2.2, 95% confidence interval [CI] = 1.7, 3.0), short duration of schooling (OR = 2.0, 95% CI = 1.3, 2.5), lack of training/education (OR = 1.4, 95% CI = 1.2, 1.7]), unskilled work (OR = 1.7, 95% CI = 1.2, 2.5), and high work-related energy expenditure (OR = 1.4, 95% CI = 1.1, 1.9) increased the likelihood of chronic H. pylori infection. Infection was frequent in people who had lived abroad. Increased levels solely of immunoglobulin M antibodies were found more often in people who were divorced (OR = 2.3, 95% CI = 1.2, 4.4) or unmarried (OR = 2.0, 95% CI = 1.1, 3.8) or who worked long hours (OR = 2.0, 95% CI = 1.1, 4.0). CONCLUSIONS: Educational and occupational factors relate to the likelihood of chronic H. pylori infection in adults. The rate of acute infection is high in single individuals.

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mentioning

confidence: 60%

Socioeconomic factors in Helicobacter pylori infection among Danish adults.

Rosenstock

Andersen²,

Rosenstock³

et al. 1996

Am J Public Health

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“…It is now accepted that H. pylori infection is usually acquired early in childhood [33]. However, nothing is known about the factors of age that allow colonisation and distribution of H. pylori in the stomach.…”

Section: Discussionmentioning

confidence: 99%

Experimental Helicobacter pylori gastric infection in miniature pigs

Koga¹,

Shimada²,

Satô³

et al. 2002

Journal of Medical Microbiology

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An experimental Helicobacter pylori infection in miniature pigs was developed and investigated. Eighteen miniature pigs were inoculated with an H. pylori strain that has high virulence in mice at c. 5 3 10 10 cfu. H. pylori infection in miniature pigs was achieved by the administration of agar 1% in brucella broth with fetal bovine serum 10% just before inoculation. The bacterial colonisation and distribution were analysed by mapping of viable cell counts in the stomach in pigs of three different ages. The mapping assay was achieved on post-infection day 3 for the 5-day-old and 2-week-old pigs, and between days 41 and 43 for 3-month-old pigs. The highest cell counts were observed in 5-day-old pigs, which averaged 4:9 3 10 6 cfu=g of mucosa (n 4). The bacteria were colonised mainly in the cardiac and fundus gland region in the 5-day-old and 2-week-old pigs, whereas the colonisation sites did not depend on the region in the 3-month-old pigs. Biopsy assay of the antral mucosa of a 3-month-old pig after H. pylori infection showed that this infection persisted for >22 months. Serum antibody against H. pylori was detected in the infected pigs but not in the uninfected animal. Immunostaining demonstrated the presence of bacteria on the epithelial surface of the infected pigs. A microscopic ®nding common to all the infected pigs, focal gastritis with in®ltration of lymphocytes detected on the lesser curvature of the stomach, resembled the microscopic appearance in H. pylori-infected human patients. These results suggest that miniature pigs might be a suitable model for studying H. pylori infection.

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“…Esses dados são de altíssima relevância, pois estudos demonstram que o tempo de duração da infecção está diretamente relacionado ao desenvolvimento de patologias associadas, particularmente a doença ulcerativa péptica e o carcinoma gástrico. 2,15,23,31,39,47,68,75,99,104 Em relação à epidemiologia da infecção pelo H. pylori, vários conceitos estão bem estabelecidos, porém outros permanecem completamente obscuros, principalmente os relacionados à via de transmissão da bactéria. Esse fato acarreta extrema dificuldade na elaboração de normas para a prevenção da doença.…”

Section: Introductionunclassified

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

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Descritores ResumoRealizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. AbstractThe scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.

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When is Helicobacter pylori infection acquired?

Abstract: Acquisition of infection in adults is rare. It is unlikely, therefore, that reinfection will occur after successful eradication.

Cited by 205 publications

References 6 publications

Socioeconomic factors in Helicobacter pylori infection among Danish adults.

Socioeconomic factors in Helicobacter pylori infection among Danish adults.

Experimental Helicobacter pylori gastric infection in miniature pigs

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

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