When our body clocks run late: does it make us depressed?

Kripke, Daniel F.

doi:10.21037/atm.2016.04.20

Cited by 8 publications

(5 citation statements)

References 16 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A negative association between the ease of getting up in the morning and depression has been reported previously. 50 Our results consistently showed causal relationships for anxiety traits such as panic attacks diagnosed by a professional and use of citalopram , a common antidepressant, 51,52 increasing the difficulty to get out of bed in the morning. Further, the age at the first episode of depression , which is a proxy for the severity and recurrence of depression, 53 showed a causal relationship with getting up, where higher age increases the ease of getting up.…”

Section: Discussionsupporting

confidence: 68%

Inference of causal relationships between sleep-related traits and 1,527 phenotypes using genetic data

García-Marín

Campos

Martin

et al. 2020

Preprint

View full text Add to dashboard Cite

Study Objective. Sleep is essential for both physical and mental health.There is an increasing interest in understanding how different factors shape individual variation in sleep duration, quality and patterns, or confer risk for sleep disorders. The present study aimed to identify novel causal relationships between sleep-related traits and other phenotypes, using a genetics-driven hypothesis-free approach not requiring longitudinal data. Methods. We used genetic data and the latent causal variable (LCV) method to screen the phenome and infer causal relationships between seven sleep-related traits (insomnia, daytime dozing, easiness of getting up in the morning, snoring, sleep duration, napping, and morningness) and 1,527 different phenotypes. Results. We identify 84 significant causal relationships. Among other findings, poor health of musculoskeletal and connective tissue disorders increase insomnia risk and reduce sleep duration; depression-related traits increase insomnia and daytime dozing; insomnia, napping and snoring are affected by obesity and cardiometabolic traits and diseases; and working with asbestos, thinner, or glues increases insomnia, potentially through an increased risk of respiratory disease. Conclusion. Overall, our results indicate that changes in sleep variables are predominantly the consequence, rather than the cause, of other underlying phenotypes and diseases. These insights could inform the design of future epidemiological and interventional studies in sleep medicine and research.

show abstract

Section: Discussionsupporting

confidence: 68%

Inference of causal relationships between sleep-related traits and 1,527 phenotypes using genetic data

García-Marín

Campos

Martin

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…It is unclear how often the circadian rhythm timing disorders have a more important role in insomnia than the cognitive-behavioral elements, but one estimate suggests that “eveningness” may be associated with trouble falling asleep in as much as one quarter of the adult population 142 . When circadian timing issues are important, properly timed bright light treatment can be a safe, effective, and inexpensive non-drug treatment that also has benefits for comorbidities such as depression, but more clinical trials are needed to better define the applicability of bright light treatment for insomnia.…”

Section: Summary Of Benefits and Risksmentioning

confidence: 99%

Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit

Kripke

2016

F1000Res

Self Cite

View full text Add to dashboard Cite

This is a review of hypnotic drug risks and benefits, reassessing and updating advice presented to the Commissioner of the Food and Drug Administration (United States FDA). Almost every month, new information appears about the risks of hypnotics (sleeping pills). This review includes new information on the growing USA overdose epidemic, eight new epidemiologic studies of hypnotics’ mortality not available for previous compilations, and new emphasis on risks of short-term hypnotic prescription. The most important risks of hypnotics include excess mortality, especially overdose deaths, quiet deaths at night, infections, cancer, depression and suicide, automobile crashes, falls, and other accidents, and hypnotic-withdrawal insomnia. The short-term use of one-two prescriptions is associated with greater risk per dose than long-term use. Hypnotics are usually prescribed without approved indication, most often with specific contraindications, but even when indicated, there is little or no benefit. The recommended doses objectively increase sleep little if at all, daytime performance is often made worse, not better, and the lack of general health benefits is commonly misrepresented in advertising. Treatments such as the cognitive behavioral treatment of insomnia and bright light treatment of circadian rhythm disorders might offer safer and more effective alternative approaches to insomnia.

show abstract

“…A systematic review concerning the gut microbiota in individuals with depression has highlighted the heightened abundance of the genus Anaerofilum in this cohort. Previous studies (Kripke, 2016) have illustrated an inverse association between ease of early rising and depressive tendencies. Hence, the heightened abundance of the genus Anaerofilum in individuals with depression precipitates the challenge of early morning awakening.…”

Section: Easiness Of Getting Up In the Morningmentioning

confidence: 84%

Association between sleep-related phenotypes and gut microbiota: a two-sample bidirectional Mendelian randomization study

Wang,

Liu

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

BackgroundAn increasing body of evidence suggests a profound interrelation between the microbiome and sleep-related concerns. Nevertheless, current observational studies can merely establish their correlation, leaving causality unexplored.Study objectivesTo ascertain whether specific gut microbiota are causally linked to seven sleep-related characteristics and propose potential strategies for insomnia prevention.MethodsThe study employed an extensive dataset of gut microbiota genetic variations from the MiBioGen alliance, encompassing 18,340 individuals. Taxonomic classification was conducted, identifying 131 genera and 196 bacterial taxa for analysis. Sleep-related phenotype (SRP) data were sourced from the IEU OpenGWAS project, covering traits such as insomnia, chronotype, and snoring. Instrumental variables (IVs) were selected based on specific criteria, including locus-wide significance, linkage disequilibrium calculations, and allele frequency thresholds. Statistical methods were employed to explore causal relationships, including inverse variance weighted (IVW), MR-Egger, weighted median, and weighted Mode. Sensitivity analyses, pleiotropy assessments, and Bonferroni corrections ensured result validity. Reverse causality analysis and adherence to STROBE-MR guidelines were conducted to bolster the study’s rigor.ResultsBidirectional Mendelian randomization (MR) analysis reveals a causative interplay between selected gut microbiota and sleep-related phenotypes. Notably, outcomes from the rigorously Bonferroni-corrected examination illuminate profound correlations amid precise compositions of the intestinal microbiome and slumber-associated parameters. Elevated abundance within the taxonomic ranks of class Negativicutes and order Selenomonadales was markedly associated with heightened susceptibility to severe insomnia (OR = 1.03, 95% CI: 1.02–1.05, p = 0.0001). Conversely, the augmented representation of the phylum Lentisphaerae stands in concord with protracted sleep duration (OR = 1.02, 95% CI: 1.01–1.04, p = 0.0005). Furthermore, heightened exposure to the genus Senegalimassilia exhibits the potential to ameliorate the manifestation of snoring symptoms (OR = 0.98, 95% CI: 0.96–0.99, p = 0.0001).ConclusionThis study has unveiled the causal relationship between gut microbiota and SRPs, bestowing significant latent value upon future endeavors in both foundational research and clinical therapy.

show abstract

When our body clocks run late: does it make us depressed?

Cited by 8 publications

References 16 publications

Inference of causal relationships between sleep-related traits and 1,527 phenotypes using genetic data

Inference of causal relationships between sleep-related traits and 1,527 phenotypes using genetic data

Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit

Association between sleep-related phenotypes and gut microbiota: a two-sample bidirectional Mendelian randomization study

Contact Info

Product

Resources

About