When Parkinson’s disease patients go to sleep: specific sleep disturbances related to Parkinson’s disease

Schulte, Eva C.; Winkelmann, Juliane

doi:10.1007/s00415-011-5933-0

Cited by 43 publications

(29 citation statements)

References 71 publications

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“…In relation to the involvement of the centers involved in the sleep-wakefulness lifecycle, it was previously reported that deposition of alpha-synuclein promotes dysfunction in dopaminergic, noradrenergic, cholinergic, serotoninergic, and hypocretinergic systems, contributing to the deterioration of sleep and wakefulness in these patients [12]. …”

Section: Discussionmentioning

confidence: 99%

High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

et al. 2017

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Objectives: To determine the frequency of major sleep disorders in patients with Parkinson’s disease (PD), diagnosed according to the third international classification of sleep disorders, and assess the relationship of those disorders with the quality of life. Methods: A cross-sectional study was performed involving 88 consecutive patients with PD from outpatient clinic. Participants were subjected to clinical interviews, assessment using standardized scales (Epworth Sleepiness Scale, PD Questionnaire, Pittsburgh sleep quality index (PSQI) and, for individuals with a diagnosis of RLS/WED, International RLS/WED grading scale), and video-polysomnography. Results: We observed sleep disorders in 96.5% of the participants, with REM-sleep behavior disorder found in 62.5%, obstructive sleep apnea in 62.5%, insomnia in 55.7%, and restless legs syndrome in 28.4%. We observed a correlation between health-related quality of life with the PSQI and the Epworth sleepiness scale. Conclusion: Patients with PD have a high prevalence of sleep disorders. The quality of sleep and excessive daytime sleepiness significantly affect the quality of life in these individuals.

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Section: Discussionmentioning

confidence: 99%

High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

et al. 2017

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“…Sleep disorders are also prevalent in PD and can occur at any stage of the disease . It affects up to two‐thirds of the patients, and they are often associated with impairment in quality of life .…”

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confidence: 99%

Global cognitive performance is associated with sleep efficiency measured by polysomnography in patients with Parkinson's disease

Sobreira

Sobreira-Neto

Pena-Pereira

et al. 2019

Psychiatry Clin Neurosci

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Aim Sleep disorders can be associated with an increased risk for cognitive decline in patients with Parkinson's disease (PD). The aim of this study was to examine the association between cognitive status and presence of sleep symptoms and sleep disorders in PD patients. Methods We evaluated excessive sleepiness, other sleep symptoms, and performed polysomnography and neuropsychological evaluation in 79 patients. They were classified as having normal cognition (PDNC), mild cognitive impairment (PDMCI), or dementia (PDD). Results There were 29 PDNC, 39 PDMCI, and 11 PDD patients. PDD patients were older, had higher scores on the Unified Parkinson's Disease Rating Scale, and lower Schwab and England Activities of Daily Living scores than PDNC patients. After analysis of the polysomnographic variables, it was also found that PDD patients had a lower sleep efficiency, lower total sleep time, and lower number of sleep state changes than PDNC patients. In a stepwise analysis, defining Mattis Dementia Rating Scale scores as the dependent variable, the results were a model that selected three variables that accounted for 59% of the variation in the Mattis Dementia Rating Scale score: wake time after sleep onset, number of state changes, and schooling. Conclusion We found a significant association between global cognitive performance and wake time after sleep onset and the number of state changes during sleep measured in the polysomnography of PD patients. However, we did not find any other association between sleep disorders or symptoms and cognitive status or cognitive performance of PD patients.

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“…Sleep disturbances are an important group of non-motor symptoms, being reported in 2/3 of PD patients (Tandberg et al, 1998) and in some cases anticipating the onset of the disease (Schenck et al, 1996). Sleep onset insomnia, sleep maintenance insomnia, excessive daytime sleepiness (EDS), REM sleep behavior disorder and sleepdisordered breathing (SDB) are sleep disorders commonly found in patients with neurodegenerative diseases (Schulte and Winkelmann, 2011). The term SDB refers to several chronic conditions in which snoring and partial or complete cessation of breathing during the night may result in daytime sleepiness and fatigue.…”

Section: Introductionmentioning

confidence: 99%

Obstructive sleep apnea syndrome in Parkinson�s disease and other parkinsonisms

Crosta¹,

Desideri²,

Marini³

2017

Functional Neurology

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SummaryAn association of obstructive sleep apnea syndrome (OSAS) and other sleep-disordered breathing (SDB) with Parkinson's disease (PD) has been reported in some small studies. In the present study we investigated the occurrence of SDB in a large consecutive outpatient series. This is a case-control study in subjects attending a neurological clinic where all patients were screened for SDB by means of sleep-wake history, Epworth Sleepiness Scale, and full-night polysomnography, when indicated. 3194 patients were recruited. Of these, 194 were affected by PD and 77 by other parkinsonisms. Snoring, excessive daytime sleepiness and OSAS were more common in patients with PD or parkinsonisms (40.59, 5.9, and 4.06%) than in controls (35.58, 2.19, and 2.09%). Our study suggests an increased frequency of OSAS and other SDB in PD and parkinsonisms. Early detection and management of these disorders may have a substantial impact on quality of life and survival in these patients.

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When Parkinson’s disease patients go to sleep: specific sleep disturbances related to Parkinson’s disease

Cited by 43 publications

References 71 publications

High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

Global cognitive performance is associated with sleep efficiency measured by polysomnography in patients with Parkinson's disease

Obstructive sleep apnea syndrome in Parkinson�s disease and other parkinsonisms

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