When to suspect a non-melanoma skin cancer

Smith, Henry B.; Wernham, Aaron; Patel, A. N.

doi:10.1136/bmj.m692

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…According to the current knowledge on NMSC development, a constellation of factors are found to be implicated such as environmental exposure to UV light (regions closer to the equator suffer from higher rates of NMSC) [5,31], radiotherapy [32], viral infections (mostly β-HPV) [3], immunosuppression (based primarily upon the increased incidence exhibited in organ transplant recipients and the twofold higher incidence rate among HIV+ patients where SCCs is positively correlated with immunosuppression) [33,34], and genetic predisposition [35].…”

Section: Etiologymentioning

confidence: 99%

“…It is estimated that approximately 1 in 5 Americans will develop skin cancer at some point in their lives by the age of 70 [2]. Unfortunately, in spite of immense efforts being made in public health awareness and primary prevention campaigns, a steady increase in skin cancer rates is observed [3][4][5]. In fact, non-melanoma skin cancer (NMSC) is the most common type with a relative incidence increase of up to 10% per annum, with 2-3 million new cases each year globally [6].…”

Section: Introductionmentioning

confidence: 99%

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Current and Future Trends in Molecular Biomarkers for Diagnostic, Prognostic, and Predictive Purposes in Non-Melanoma Skin Cancer

Νikolouzakis

Falzone

Lasithiotakis

et al. 2020

JCM

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Skin cancer represents the most common type of cancer among Caucasians and presents in two main forms: melanoma and non-melanoma skin cancer (NMSC). NMSC is an umbrella term, under which basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and Merkel cell carcinoma (MCC) are found along with the pre-neoplastic lesions, Bowen disease (BD) and actinic keratosis (AK). Due to the mild nature of the majority of NMSC cases, research regarding their biology has attracted much less attention. Nonetheless, NMSC can bear unfavorable characteristics for the patient, such as invasiveness, local recurrence and distant metastases. In addition, late diagnosis is relatively common for a number of cases of NMSC due to the inability to recognize such cases. Recognizing the need for clinically and economically efficient modes of diagnosis, staging, and prognosis, the present review discusses the main etiological and pathological features of NMSC as well as the new and promising molecular biomarkers available including telomere length (TL), telomerase activity (TA), CpG island methylation (CIM), histone methylation and acetylation, microRNAs (miRNAs), and micronuclei frequency (MNf). The evaluation of all these aspects is important for the correct management of NMSC; therefore, the current review aims to assist future studies interested in exploring the diagnostic and prognostic potential of molecular biomarkers for these entities.

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Section: Etiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Current and Future Trends in Molecular Biomarkers for Diagnostic, Prognostic, and Predictive Purposes in Non-Melanoma Skin Cancer

Νikolouzakis

Falzone

Lasithiotakis

et al. 2020

JCM

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“…The most common skin cancer is BCC which accounts for 80% of all skin malignancies (ratio of incidence compare with SCC is between 10:1 and 1:1) [9]. MM accounts for 1.5-2% of all skin cancers [10,11].…”

Section: Skin Cancersmentioning

confidence: 99%

Nanotechnology as a Promising Method in the Treatment of Skin Cancer

Adamus-Grabicka,

Hikisz,

Sikora

2024

IJMS

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The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, of which nearly 350,000 are melanoma, which is often fatal. Treatment is challenging and often ineffective, with conventional chemotherapy playing a limited role in this context. These disadvantages can be overcome by the use of nanoparticles and may allow for the early detection and monitoring of neoplastic changes and determining the effectiveness of treatment. This article briefly reviews the present understanding of the characteristics of skin cancers, their epidemiology, and risk factors. It also outlines the possibilities of using nanotechnology, especially nanoparticles, for the transport of medicinal substances. Research over the previous decade on carriers of active substances indicates that drugs can be delivered more accurately to the tumor site, resulting in higher therapeutic efficacy. The article describes the application of liposomes, carbon nanotubes, metal nanoparticles, and polymer nanoparticles in existing therapies. It discusses the challenges encountered in nanoparticle therapy and the possibilities of improving their performance. Undoubtedly, the use of nanoparticles is a promising method that can help in the fight against skin cancer.

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“…3 Squamous cell carcinomas often feature scaled, reddened patches that may become tender and ulcerate. 4 ❚ Hordeolums and chalazions. A hordeolum (or stye) is a painful, acute, localized swelling of the eyelid.…”

Section: A Lesson In Considering the Full Differentialmentioning

confidence: 99%

Slow-growing lesion on eyebrow

Grover

Chavez

Nelson

et al. 2021

The Journal of Family Practice

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It took a dermatoscopic examination followed by an e-consultation and shave biopsy to arrive at the diagnosis. a 51-year-old woman presented to the family medicine clinic for evaluation of a slightly tender skin lesion on her left eyebrow. The lesion had been slowly growing for a year.The patient's family history included multiple family members with colon or breast cancer and other relatives with pancreatic and prostate cancer. A colonoscopy performed a year earlier on the patient was negative. The patient's past medical history included hypertension, major depressive disorder, hyperlipidemia, and venous insufficiency. She also had a colon polyp history.

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When to suspect a non-melanoma skin cancer

Cited by 7 publications

References 25 publications

Current and Future Trends in Molecular Biomarkers for Diagnostic, Prognostic, and Predictive Purposes in Non-Melanoma Skin Cancer

Current and Future Trends in Molecular Biomarkers for Diagnostic, Prognostic, and Predictive Purposes in Non-Melanoma Skin Cancer

Nanotechnology as a Promising Method in the Treatment of Skin Cancer

Slow-growing lesion on eyebrow

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