2017
DOI: 10.17140/hroj-4-144
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Where are Cell-Based Therapies Heading? Current Limitations and Future Directions

Abstract: Congestive heart failure (CHF) secondary to chronic coronary artery disease is a major cause of morbidity and mortality worldwide. Its prevalence is increasing despite advances in medical and device therapies. Adult stem cell therapies have emerged as a promising treatment generating new cardiomyocytes and vessels, and are anticipated to reverse functional deterioration in patients with congestive heart failure for whom heart transplantation is the only cure. This field was enthusiastically studied in last two… Show more

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Cited by 1 publication
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“…Moreover, seeding of single cells requires time for the cells to attach to the area, resulting in loss of some cells before they can attach. This is similar to in vivo situations, where cell therapy by injection of cells fails to deliver the cells to target sites unless biomaterials are used for cell transport (Suzuki et al, 2018). We demonstrate that the 3D-DF can be grafted onto the wounded dermis in vitro.…”
Section: Discussionmentioning
confidence: 55%
“…Moreover, seeding of single cells requires time for the cells to attach to the area, resulting in loss of some cells before they can attach. This is similar to in vivo situations, where cell therapy by injection of cells fails to deliver the cells to target sites unless biomaterials are used for cell transport (Suzuki et al, 2018). We demonstrate that the 3D-DF can be grafted onto the wounded dermis in vitro.…”
Section: Discussionmentioning
confidence: 55%