Where ferroptosis inhibitors and paraquat detoxification mechanisms intersect, exploring possible treatment strategies

Rashidipour, Niloofar; Karami‐Mohajeri, Somayyeh; Mandegary, Ali; Mohammadinejad, Reza; Wong, Anselm; Mohit, Melika; Salehi, J.; Ashrafizadeh, Milad; Najafi, Amir H.; Abiri, Ardavan

doi:10.1016/j.tox.2020.152407

Cited by 24 publications

(19 citation statements)

References 123 publications

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“…Studies suggest that ferroptosis is related to PF caused by paraquat, and applying ferroptosis inhibitors may be an effective therapy to reduce paraquat poisoning. 77 , 96 …”

Section: Ferroptosis and Lung Diseasesmentioning

confidence: 99%

“…Studies suggest that ferroptosis is related to PF caused by paraquat, and applying ferroptosis inhibitors may be an effective therapy to reduce paraquat poisoning. 77,96 In addition, ferroptosis is also related to the fibrosis of other organs. Inhibition of ferroptosis by fer-1 can improve myocardial fibrosis in mice, and application of fer-1 or knockout of p53 to inhibit ferroptosis of hepatic stellate cells can aggravate liver fibrosis in mice.…”

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confidence: 99%

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Role of Ferroptosis in Lung Diseases

Xu¹,

Deng²,

Hu³

et al. 2021

JIR

102

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Ferroptosis is a new type of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative stress and cell death. The metabolism of iron, lipids, and amino acids and multiple signalling pathways precisely regulate the process of ferroptosis. Emerging evidence has demonstrated that ferroptosis participates in the occurrence and progression of various pathological conditions and diseases, such as infections, neurodegeneration, tissue ischaemia-reperfusion injury and immune diseases. Recent studies have also indicated that ferroptosis plays a critical role in the pathogenesis of acute lung injury, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary infection and asthma. Herein, we summarize the latest knowledge on the regulatory mechanism of ferroptosis and its association with iron, lipid and amino acid metabolism as well as several signalling pathways. Furthermore, we review the contribution of ferroptosis to the pathogenesis of lung diseases and discuss ferroptosis as a novel therapeutic target for various lung diseases.

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“…Studies suggest that ferroptosis is related to PF caused by paraquat, and applying ferroptosis inhibitors may be an effective therapy to reduce paraquat poisoning. 77 , 96 …”

Section: Ferroptosis and Lung Diseasesmentioning

confidence: 99%

mentioning

confidence: 99%

Role of Ferroptosis in Lung Diseases

Xu¹,

Deng²,

Hu³

et al. 2021

JIR

102

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“…Moreover, erastin can promote fibroblast-to-myofibroblast differentiation by inhibiting the GPX4 expression and accelerating lipid peroxidation in HFL1 cell line [ 118 ]. Other studies suggest that ferroptosis is involved in paraquat- (PQ-) induced pulmonary damage and ferroptosis inhibitors might be promising therapeutics in alleviating PQ poisoning [ 119 ]. It is also found that ferroptosis is involved in the fibrosis of other organs including the liver and heart [ 120 , 121 ].…”

Section: Main Textmentioning

confidence: 99%

Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease

Tao

Liu

2020

Oxidative Medicine and Cellular Longevity

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Ferroptosis is a new mode of cell death that is characterized by the excessive accumulation of iron and lipid peroxides. It has unique morphological changes and disparate biochemical features and plays an intricate role in many pathophysiological processes. A great deal of researches confirms that ferroptosis can be regulated by numerous molecules through different mechanisms, supporting great potentials for novel pharmacological therapeutics. Recently, several studies reveal that ferroptosis is also closely associated with the initiation and development of respiratory disease. Understanding the specific mechanism, the molecular trait of ferroptosis and their relationship with pulmonary disease could provide significant references regarding effective treatment of these obstinate disease.

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“…Paraquat, as a wide-spectrum but toxic herbicide, is now restricted for use in various agricultural production processes. It can cause the production of high-energy oxygen free radicals and glutathione peroxidase 4 (GPX4) inactivation, and ultimately multiorgan failure and pulmonary fibrosis [ 26 ]. Some works have also reported a relationship between paraquat and increased risk for Parkinson’s disease [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

A Fluorescent Detection for Paraquat Based on β-CDs-Enhanced Fluorescent Gold Nanoclusters

Ren

Mao

et al. 2021

Foods

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In this report, a fluorescent sensing method for paraquat based on gold nanoclusters (AuNCs) is proposed. It was found that paraquat could quench both glutathione-capped AuNCs (GSH-AuNCs) and β-cyclodextrin-modified GSH-AuNCs (GSH/β-CDs-AuNCs). The modification of β-CDs on the surface of GSH-AuNCs obviously enhanced the fluorescence intensity of GSH-AuNCs and improved the sensitivity of paraquat sensing more than 4-fold. This sensibilization was ascribed to the obvious fluorescence intensity enhancement of GSH-AuNCs by β-CDs and the “host–guest” interaction between paraquat and β-CDs. The fluorescence quenching was mainly due to the photoinduced energy transfer (PET) between GSH/β-CDs-AuNCs and paraquat. With the optimized β-CDs modification of the GSH-AuNC surfaces and under buffer conditions, the fluorescent detection for paraquat demonstrated a linear response in the range of 5.0–350 ng/mL with a detection limit of 1.2 ng/mL. The fluorescent method also showed high selectivity toward common pesticides. The interference from metal ions could be easily masked by ethylene diamine tetraacetic acid (EDTA). This method was applied to the measurement of paraquat-spiked water samples and good recoveries (93.6–103.8%) were obtained. The above results indicate that host molecule modification of fluorescent metal NC surfaces has high potential in the development of robust fluorescent sensors.

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Where ferroptosis inhibitors and paraquat detoxification mechanisms intersect, exploring possible treatment strategies

Cited by 24 publications

References 123 publications

Role of Ferroptosis in Lung Diseases

Role of Ferroptosis in Lung Diseases

Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease

A Fluorescent Detection for Paraquat Based on β-CDs-Enhanced Fluorescent Gold Nanoclusters

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