Where is the mind within the brain? Transient selection of subnetworks by metabotropic receptors and G protein-gated ion channels

Nikolić, Danko

doi:10.1016/j.compbiolchem.2023.107820

Cited by 5 publications

(1 citation statement)

References 74 publications

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“…Many components of cytoskeleton themselves support information processing, learning and memory [79][80][81] . Proteins at synapses enable spike timing dependent plasticity (STDP) 82 along with long term potentiation and depression 83 .…”

Section: The Cytoelectric Coupling Hypothesismentioning

confidence: 99%

Cytoelectric Coupling: Electric fields sculpt neural activity and “tune” the brain’s infrastructure.

Pinotsis¹,

Fridman²,

Miller³

2023

Preprint

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We propose and present converging evidence for the Cytoelectric Coupling Hypothesis: Electric fields generated by neurons are causal down to the level of the cytoskeleton. This could be achieved via electrodiffusion and mechanotransduction and exchanges between electrical, potential and chemical energy. Ephaptic coupling organizes neural activity, forming neural ensembles at the macroscale level. This information propagates to the neuron level, affecting spiking, and down to molecular level to stabilize the cytoskeleton, “tuning” it to process information more efficiently.

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