Where new approaches can stem from: Focus on stem cell identification

Adams, Volker; Challen, Grant A.; Zuba‐Surma, Ewa; Ulrich, Henning; Vereb, György; Tárnok, Attila

doi:10.1002/cyto.a.20695

Cited by 16 publications

(12 citation statements)

References 11 publications

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“…The determination of the origin and identity of SCs together with their niches in adult tissue also provides important information on their participation in endogenous tissue regeneration and their possible applications as pluri-or multipotent cells in cellular regeneration therapy (6,7,(27)(28)(29)(30)(31)(32)(33). Evidence accumulated in the last few years show that the adult macro-and microvessels contain multi-or pluripotent SCs, including MSCs, and/or pericytes, as well as hemopoietic SCs, and lineage committed progenitors, such as vascular walls endothelial progenitor and Sca-1 1 smooth muscle progenitor cells (6,7,23,(29)(30)(31)(33)(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

Neural differentiation of rat aorta pericyte cells

et al. 2011

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Pericyte perivascular cells, believed to originate mesenchymal stem cells (MSC), are characterized by their capability to differentiate into various phenotypes and participate in tissue reconstruction of different organs, including the brain. We show that these cells can be induced to differentiation into neural-like phenotypes. For these studies, pericytes were obtained from aorta ex-plants of Sprague-Dawley rats and differentiated into neural cells following induction with trans retinoic acid (RA) in serum-free defined media or differentiation media containing nerve growth and brain-derived neuronal factor, B27, N2, and IBMX. When induced to differentiation with RA, cells express the pluripotency marker protein stage-specific embryonic antigen-1, neural-specific proteins b3-tubulin, neurofilament-200, and glial fibrillary acidic protein, suggesting that pericytes undergo differentiation, similar to that of neuroectodermal cells. Differentiated cells respond with intracellular calcium transients to membrane depolarization by KCl indicating the presence of voltage-gated ion channels and express functional Nmethyl-D-aspartate receptors, characteristic for functional neurons. The study of neural differentiation of pericytes contributes to the understanding of induction of neuroectodermal differentiation as well as providing a new possible stem-cell source for cell regeneration therapy in the brain. ' 2011 International Society for Advancement of Cytometry

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Section: Discussionmentioning

confidence: 99%

Neural differentiation of rat aorta pericyte cells

et al. 2011

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“…In most cases a combination of a hematopoietic stem cell marker, like CD34, CD117 (cKit), or CD133, with a marker for endothelial cells, like vascular endothelial growth factor receptor 2 (KDR) or Ve-cadherin, are used to identify EPCs (summarized in Refs. 1,28,81). The combination of CD34 ϩ /KDR ϩ is the most often used set for quantification of EPCs in the current literature.…”

Section: Definition and Detectionmentioning

confidence: 99%

Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease

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Uhlemann

Schuler

et al. 2011

Journal of Applied Physiology

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“…On the basis of these new data, we updated our previous phenotypic table by a set of seven new cell types isolated from additional organs and include a set of additional markers not present in the earlier overview (2). Therefore, we asked all authors to revisit the table and upgrade their part either by own data or based on additional literature, as necessary.…”

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confidence: 99%