Whey protein capsules obtained through electrospraying for the encapsulation of bioactives

López‐Rubio, Amparo; Lagarón, José M.

doi:10.1016/j.ifset.2011.10.012

Cited by 217 publications

(79 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The polydispersity of the capsules containing β-carotene is also higher for the 5 and 10% ethanol concentrations and similar at 15%. The increase in capsule size with the incorporation of βcarotene was reported previously with electrosprayed β-carotene loaded in whey protein concentrate systems (López-Rubio & Lagaron, 2012). In this study the increase in capsule size was only noticed by DLS measurements, reflecting changes between 200 and 300 nm in the capsule average size.…”

Section: Size and Morphology Of The Hydrated Nanocapsulessupporting

confidence: 54%

“…These results are in agreement with the expectations for this processing methodology and corroborate other works reported in literature. Other works using WPC resulted in capsules with sizes bellow 2 µm (López-Rubio & Lagaron, 2012;Pérez-Masiá et al, 2015). Sullivan, Tang, Kennedy, Talwar, and Khan (2014) also used ethanol (20%, v/v) to improve the electrohydrodynamic processing of WPI, however on that study the authors aimed to obtain fibers.…”

Section: Size and Morphology Of The Dried Nanocapsulesmentioning

confidence: 99%

See 1 more Smart Citation

Electrosprayed whey protein-based nanocapsules for β-carotene encapsulation

et al. 2020

View full text Add to dashboard Cite

A B S T R A C TIn this work an electrohydrodynamic process (electrospray) was used to produce β-carotene loaded nanocapsules based on whey protein isolate (WPI). WPI solutions were prepared in aqueous solutions with different concentrations of ethanol (5, 10 and 15%) which were used for β-carotene solubilization. Different electrospray conditions were tested and the morphology and molecular organization of the nanocapsules were studied on dried and hydrated state. The size of the dried nanocapsules ranged between 227 and 283 nm. After hydration, there was a significant increase in the mean size of the nanocapsules, being the sizes higher for nanocapsules produced with increasing concentrations of ethanol. Results, obtained from the reactivity of free sulfhydryl groups and fluorescence analysis, showed that the increase of ethanol concentration had a destabilizing effect on the protein unfolding.Electrosprayed WPI-based nanocapsules can be used for the encapsulation of β-carotene answering the industrial demand for novel encapsulation technologies to protect sensitive bioactive compounds.

show abstract

Section: Size and Morphology Of The Hydrated Nanocapsulessupporting

confidence: 54%

Section: Size and Morphology Of The Dried Nanocapsulesmentioning

confidence: 99%

Electrosprayed whey protein-based nanocapsules for β-carotene encapsulation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…To date, electrospraying has been widely employed as valid alternative to gold standard technologies for a broader applicability spectrum, i.e. nanoparticles, nanostructured coating and drug loaded capsules . Only recently, nanoparticles fabricated by electrospraying have been successfully used to functionalize ECM analogues in the form of electrospun matrices able to release bioactive signals or drugs for multiscale and targeted delivery …”

Section: Introductionmentioning

confidence: 99%

Additive electrospraying: a route to process electrospun scaffolds for controlled molecular release

Guarino

Altobelli

Cirillo

et al. 2015

Polymers for Advanced Techs

View full text Add to dashboard Cite

Electrohydrodynamics-i.e. electrospinning, electrospraying and atomization-are gaining a growing interest in drug delivery applications, because of a large number of advantages including improved therapeutic index, localized delivery/targeting and controlled drugs toxicity level. In the past, microstructured platforms fabricated by the assembly of electrospun fibers have demonstrated to exhibit interesting features as bioactive carriers including extended surface area and high molecular permeability because of fully interconnected pore architecture, thus making the opportunity to incorporate a wide range of actives/drugs for different use. In these systems, molecular release occurs via various molecular transport pathways namely diffusion, desorption and scaffold degradation which may be tuned through a careful control of fiber morphology and composition. However, several shortcomings still concern the possibility to incorporate bioactive species, not exposing molecules to fast and/or uncontrolled denaturation, thus preserving biochemical and biological fiber functionalities. In this context, additive electro spraying (AES)-i.e. integration of electrosprayed nanoparticles into electrospun fiber network-is emerging as interesting route to control "separately" release and functional properties of the scaffolds in order to support cell activities by independent cues, during the tissue formation. Here, we describe the current advances on the use of electrospraying and/or electrospinning until more innovative integrated AES approaches to design molecularly loaded platforms able to spatially and timely release active molecules for different use in tissue engineering and molecular targeting.

show abstract

“…Above this temperature, the proteins partially unfold and associate with each other through hydrophobic attraction and disulfide bond formation. Whey protein‐based systems have been used for the encapsulation of β‐carotene (López‐Rubio & Lagaron, ), caffeine (Gunasekaran et al., ), epigallocatechin‐3‐gallate (Shpigelman, Cohen, & Livney, ), bilberry extract (Betz et al., ), date palm pit extract (Bagheri, Madadlou, Yarmand, & Mousavi, ; Sadeghi, Madadlou, & Yarmand, ), and probiotics (using nanofibers; López‐Rubio, Sanchez, Wilkanowicz, Sanz, & Lagaron, ). Delivery systems can be produced using whole whey proteins or their fractions such as β‐lactoglobulin (β‐Lg), α‐lactalbumin (α‐LA), and bovine serum albumin (BSA).…”

Section: Protein‐based Encapsulating Materialsmentioning

confidence: 99%

Protein‐Based Delivery Systems for the Nanoencapsulation of Food Ingredients

Fathi

Donsı̀

McClements

2018

Comp Rev Food Sci Food Safe

211

View full text Add to dashboard Cite

Many proteins possess functional attributes that make them suitable for the encapsulation of bioactive agents, such as nutraceuticals and pharmaceuticals. This article reviews the state of the art of protein-based nanoencapsulation approaches. The physicochemical principles underlying the major techniques for the fabrication of nanoparticles, nanogels, and nanofibers from animal, botanical, and recombinant proteins are described. Protein modification approaches that can be used to extend their functionality in these nanocarrier systems are also described, including chemical, physical, and enzymatic treatments. The encapsulation, retention, protection, and release of bioactive agents in different protein-based nanocarriers are discussed. Finally, some of the major challenges in the design and fabrication of protein-based delivery systems are highlighted.

show abstract

Whey protein capsules obtained through electrospraying for the encapsulation of bioactives

Cited by 217 publications

References 25 publications

Electrosprayed whey protein-based nanocapsules for β-carotene encapsulation

Electrosprayed whey protein-based nanocapsules for β-carotene encapsulation

Additive electrospraying: a route to process electrospun scaffolds for controlled molecular release

Protein‐Based Delivery Systems for the Nanoencapsulation of Food Ingredients

Contact Info

Product

Resources

About