Whey protein peptides PEW and LLW synergistically ameliorate hyperuricemia and modulate gut microbiota in potassium oxonate and hypoxanthine-induced hyperuricemic rats

Qi, Xiaofen; Guan, Kaifang; Liu, C. M.; Chen, Haoran; Ma, Ying; Wang, Rongchun

doi:10.3168/jds.2023-23369

Cited by 7 publications

(2 citation statements)

References 45 publications

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“…In HUA rats, WPH and peptide PEW downregulate the levels of mRNA and protein expression of URAT1 while upregulating the levels of mRNA and protein expression of OAT1. Additionally, WPH promotes ABCG2 expression at the mRNA level, reversing the tendency in rats toward lowering urine UA [64]. URAT1 and GLUT9 protein expression levels decrease, whereas ABCG2 protein expression levels increase in HUA mice following an anserine gastric injection [102].…”

Section: Peptides That Regulate the Expression Levels Of Ua Transportersmentioning

confidence: 95%

“…Subsequently, PEW and LLW, both displaying the strongest XO inhibitory activity, were synthesized. These peptides form stable complexes with key amino acids of XO through hydrogen bonds and hydrophobic interactions, preventing the substrate from binding to XO [64]. Four novel XO inhibitory peptides, GL, PM, AL, and AM, have been identified from whey protein, exhibiting strong XO inhibitory activity in vitro.…”

Section: Milkmentioning

confidence: 99%

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Understanding Hyperuricemia: Pathogenesis, Potential Therapeutic Role of Bioactive Peptides, and Assessing Bioactive Peptide Advantages and Challenges

Chen,

Yang,

Rao

et al. 2023

Foods

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Hyperuricemia is a medical condition characterized by an elevated level of serum uric acid, closely associated with other metabolic disorders, and its global incidence rate is increasing. Increased synthesis or decreased excretion of uric acid can lead to hyperuricemia. Protein peptides from various food sources have demonstrated potential in treating hyperuricemia, including marine organisms, ovalbumin, milk, nuts, rice, legumes, mushrooms, and protein-rich processing by-products. Through in vitro experiments and the establishment of cell or animal models, it has been proven that these peptides exhibit anti-hyperuricemia biological activities by inhibiting xanthine oxidase activity, downregulating key enzymes in purine metabolism, regulating the expression level of uric acid transporters, and restoring the composition of the intestinal flora. Protein peptides derived from food offer advantages such as a wide range of sources, significant therapeutic benefits, and minimal adverse effects. However, they also face challenges in terms of commercialization. The findings of this review contribute to a better understanding of hyperuricemia and peptides with hyperuricemia-alleviating activity. Furthermore, they provide a theoretical reference for developing new functional foods suitable for individuals with hyperuricemia.

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Section: Peptides That Regulate the Expression Levels Of Ua Transportersmentioning

confidence: 95%

Section: Milkmentioning

confidence: 99%

Understanding Hyperuricemia: Pathogenesis, Potential Therapeutic Role of Bioactive Peptides, and Assessing Bioactive Peptide Advantages and Challenges

Chen,

Yang,

Rao

et al. 2023

Foods

View full text Add to dashboard Cite

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Food-derived bioactive peptides with anti-hyperuricemic activity: A comprehensive review

Mehmood,

Iftikhar,

Chen

2024

Food Chemistry

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Integrated microbiome and metabolome analysis reveals the key role of taurohyocholate in the treatment of hyperuricemia with Lacticaseibacillus rhamnosus 2016SWU.05.0601

Chen,

Yan,

Yang

et al. 2024

Food Research International

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Whey protein peptides PEW and LLW synergistically ameliorate hyperuricemia and modulate gut microbiota in potassium oxonate and hypoxanthine-induced hyperuricemic rats

Cited by 7 publications

References 45 publications

Understanding Hyperuricemia: Pathogenesis, Potential Therapeutic Role of Bioactive Peptides, and Assessing Bioactive Peptide Advantages and Challenges

Understanding Hyperuricemia: Pathogenesis, Potential Therapeutic Role of Bioactive Peptides, and Assessing Bioactive Peptide Advantages and Challenges

Food-derived bioactive peptides with anti-hyperuricemic activity: A comprehensive review

Integrated microbiome and metabolome analysis reveals the key role of taurohyocholate in the treatment of hyperuricemia with Lacticaseibacillus rhamnosus 2016SWU.05.0601

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