Which Lesions Are at Higher Risk of Developing Colorectal Carcinomas: Superficially Elevated Serrated Lesions or Depressed Lesions?

Parada, Artur Adolfo; Venco, Filadelfio Euclydes; Varca-Neto, Miguel Reynaldo; Ibrahim, Roberto El; Poletti, Paula; Brito, Hélcio Pedrosa; Sare, Heloisa de Fátima; Malafaia, Osvaldo

doi:10.1590/0102-672020220002e1716

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…The prevalence of adenomas increases with age, affects both genders similarly, and is associated with a hereditary predisposition to sporadic forms. Histologically, adenomas can be classified into three subtypes: tubular, villous, and tubulovillous 20 . The risk of malignant transformation is independently associated with polyp size, histological architecture, and degree of dysplasia.…”

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer: Histopathological Profile and Prevalence of Dna Repair System Deficiency in Patients Submitted to Surgical Treatment in a University Hospital

Oliveira,

Moraes,

Mehanna

et al. 2023

ABCD, arq. bras. cir. dig.

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BACKGROUND: Part of colorectal cancer cases occurs due to modifications in the DNA mismatch repair system, which are responsible for microsatellite instability. This alteration results in an unconventional phenotypic pattern of colorectal cancer. AIMS: To describe the epidemiological, histopathological and molecular profiles of patients with colorectal cancer who underwent surgical treatment in a reference hospital. METHODS: This is a cross-sectional, retrospective study with a quantitative approach, that included a review of patients’ medical records who underwent oncological surgery for colorectal cancer. RESULTS: A total of 122 colorectal cancer cases were identified, with microsatellite instability detected in 8.2% of the sample. The gender distribution was similar, with 52.46% males, and the weighted average age was 63 years (standard deviation±11.65). However, in the microsatellite instability group, the predominant age was below 60 years. Regarding the histological type, adenocarcinoma not otherwise specified accounted for 80.33% of the cases, being the most prevalent in both groups, with the mucinous type being more frequent among the instability cases. The pT3 pathological staging (46.72%) was the most predominant. The topography was more prevalent on the left (60.66%), but there was a significant difference when compared to the group with microsatellite instability, in which 80% of the neoplasms were located on the right (p=0.006). CONCLUSIONS: Differences in age and neoplastic topography found in microsatellite instability samples highlight the distinctive presentation pattern of the disease. Recognizing these characteristics is essential for developing prevention strategies, in addition to early and accurate diagnosis of colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Colorectal Cancer: Histopathological Profile and Prevalence of Dna Repair System Deficiency in Patients Submitted to Surgical Treatment in a University Hospital

Oliveira,

Moraes,

Mehanna

et al. 2023

ABCD, arq. bras. cir. dig.

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Macroscopic and Histological Analysis on Endoscopically Resected Rectal Lesions

Frugis¹,

Ribas

Malafaia

et al. 2023

ABCD, arq. bras. cir. dig.

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BACKGROUND: Colorectal cancer is among the most common malignancies worldwide. Colonoscopy is the examination of choice for the prevention of CRC because of its great diagnostic and, especially, therapeutic capacity in relation to adenomatous lesions. AIMS: This study aimed to analyze the prevalence, macroscopic, and histological characteristics of polypoid rectal lesions resected through endoscopic techniques and assess whether endoscopic therapy is safe and efficient for treating lesions located in the rectum. METHODS: This is a retrospective observational study with an analysis of the medical records of all patients undergoing resection of rectal polyps. RESULTS: A total of 123 patients with rectal lesions were evaluated, with 59 men and 64 women of mean age 56 years. All patients underwent endoscopic resection: 70% with polypectomy and 30% with wide mucosectomy. Complete colonoscopy with removal of the entire rectal lesion occurred in 91%, while in 5% the preparation was inadequate and poor clinical conditions were an impeditive factor, and in 4% surgical treatment was indicated because there was an infiltrative lesion with central ulceration. Histological evaluation showed adenomas in 3.25%, hyperplasia in 7.32%, and hamartoma in 0.81%; low-grade dysplasia was identified in 34.96%, high-grade dysplasia in 51.22%, and adenocarcinoma in 1.63%, while one case (0.81%) was classified as erosion. CONCLUSIONS: Polyps in the rectum are common and were found in 37% of these colonoscopies. Adenomas with dysplasia were the most common form of Colorectal cancer . Therapeutic colonoscopy proved to be a safe and efficient method for the complete treatment of rectal lesions.

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Which Lesions Are at Higher Risk of Developing Colorectal Carcinomas: Superficially Elevated Serrated Lesions or Depressed Lesions?

Cited by 2 publications

References 33 publications

Colorectal Cancer: Histopathological Profile and Prevalence of Dna Repair System Deficiency in Patients Submitted to Surgical Treatment in a University Hospital

Colorectal Cancer: Histopathological Profile and Prevalence of Dna Repair System Deficiency in Patients Submitted to Surgical Treatment in a University Hospital

Macroscopic and Histological Analysis on Endoscopically Resected Rectal Lesions

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