Which Occurs First in Patients with Type 2 Diabetes Mellitus? Central or Peripheral Neuropathy

Panta, Raju; Khadka, Rita; Thakur, Dilip; Limbu, Nirmala; Paudel, Bishnu Hari

doi:10.21276/iabcr.2016.2.2.16

Cited by 3 publications

(9 citation statements)

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“…However, up to 50% of patients do not have symptoms of neuropathy [1]. Some studies have reported the evidences of central neuropathy in T2DM patients, though the patients do not have symptoms of central nervous system (CNS) impairment [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological status of sural nerves in type 2 diabetes mellitus patients before symptomatic peripheral neuropathy

Panta

Thakur

Paudel

2017

Clinical Diabetology

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Section: Introductionmentioning

confidence: 99%

Electrophysiological status of sural nerves in type 2 diabetes mellitus patients before symptomatic peripheral neuropathy

Panta

Thakur

Paudel

2017

Clinical Diabetology

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“…The studies have shown that the EEG power spectra of delta and beta activity are more in T2DM patients at most of the brain regions (8,9) and hyperventilation helps to increase the yield of EEG. Diffuse EEG changes characteristically occur in metabolic encephalopathies unless there is a pre-existing or concomitant structural lesion.…”

Section: Discussion:-mentioning

confidence: 99%

“…Several studies have reported the manifestations of cerebral disorders in type 2 diabetes mellitus (T2DM) at neurochemical, electrophysiological, structural, and neurobehavioral levels (3,8,9). The alterations in cerebral…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

“…Patients with T2DM have increased EEG activity in low-frequency slow waves and high-frequency fast waves indicative of diffuse central neuropathy (8). Baskaran et al reported similar neurophysiological abnormalities in both DM and MDD, including elevated EEG activity in low-frequency slow waves (9).…”

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confidence: 98%

“…The prolonged existence of any response in EEG after cessation of HV is abnormal (10). Some studies have reported central neuropathy in DM as evidenced by EEG changes (3,8). To the best of our knowledge, very few studies have recorded EEG changes in DM during HV.…”

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Electroencephalographic Changes in Type 2 Diabetes Mellitus During Hyperventilation and Post-Hyperventilation

Panta¹,

Paudel²,

Limbu³

2017

IJAR

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Diabetes mellitus is the most common metabolic disorder that results in various complications including the brain abnormalities. Hyperventilation (HV) is a classic activation procedure during routine electroencephalography (EEG) recording that increases the yield of electrical activity generated in the cerebral cortex. Objectives: To investigate the electroencephalographic (EEG) changes in type 2 diabetes mellitus (T2DM) patients during hyperventilation (HV) and post-HV. Methods: The 16-channel EEG recording of 35 male patients with T2DM on oral hypoglycemic medication and 35 age-and sex-matched healthy subjects (controls) were done during and after hyperventilation for 3 minutes each. The quantitative EEG analysis was done using Fast Fourier Transformation (FFT). The EEG power spectra were subjected to log-transformation and compared using student's t-test. Results: The T2DM patients had diffuse increase in low-frequency slow waves at delta range (p <0.05) and high-frequency fast waves at beta range (p <0.05) as compared to the controls in EEG during HV. There was a prolonged existence of delta activity at few brain regions (p <0.05) and beta activity in some brain regions (p <0.05) in the EEG after cessation of HV during post-HV. Conclusion: The increased yield of EEG activity at delta and beta ranges in T2DM patients during HV and the prolonged existence of these responses after cessation of HV are suggestive of central nervous system (CNS) abnormalities in T2DM patients. Copy Right, IJAR, 2017. All rights reserved. …………………………………………………………………………………………………….... Introduction:-Diabetes mellitus (DM) remains most common metabolic disorder, with an estimated 415 million adults affected by diabetes worldwide (1). A complex interaction of direct and indirect metabolic consequences of insulin deficiency and additional genetic and environmental factors result in chronic complications affecting nephrons, blood vessels, retina, and neurons (2).Several studies have reported the manifestations of cerebral disorders in type 2 diabetes mellitus (T2DM) at neurochemical, electrophysiological, structural, and neurobehavioral levels (3,8,9). The alterations in cerebral

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Brain Wave Changes during Cognitive Task Performance in Uncomplicated Diabetic Adults: An Exploratory Study

Sim

Ahadon

Sohail

2022

imjm

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Introduction: Diabetes mellitus (DM) is a chronic disease associated with cognitive decline and dementia in the elderly population. This exploratory study analysed the brain wave changes during cognitive task performance in working adults with and without type 2 diabetes mellitus (T2DM). MATERIALS AND Methods: The Mini-Mental State Examination was used to screen subject’s cognitive function and quantitative electroencephalography was used to analyse subject’s brain waves at rest and whilst performing the serial seven test. Results: When performing the serial seven test, the diabetic group showed a higher absolute power of theta waves in the left frontal (Fp1, 16.22 ± 3.81 vs 3.75 ± 1.69; p = 0.022) and temporal regions (T3, 24.27 ± 3.69 vs 7.92 ± 2.17; p = 0.045), but lower absolute power of beta waves in both the frontal regions (Fp1, 27.35 ± 3.67 vs 41.14 ± 5.67; p = 0.029; Fp2, 23.01 ± 3.31 vs 39.05 ± 2.64; p = 0.041) and left temporal region (T3, 37.93 ± 4.64 vs 50.94 ± 3.56; p = 0.046) when compared to those of the control group. The diabetic group took longer to complete the task (127.9 ± 8.3 s vs 95.6 ± 5.9 s; p = 0.032) than the control group, despite no statistically significant difference in correct response rates. Diabetes duration was positively correlated with the theta/alpha ratio in the left frontal (Fp1, r = 0.525; p = 0.041) and temporal (T3, r = 0.618; p = 0.037) regions. Conclusions: T2DM may affect cognitive function in patients before clinical manifestation.

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Which Occurs First in Patients with Type 2 Diabetes Mellitus? Central or Peripheral Neuropathy

Cited by 3 publications

References 0 publications

Electrophysiological status of sural nerves in type 2 diabetes mellitus patients before symptomatic peripheral neuropathy

Electrophysiological status of sural nerves in type 2 diabetes mellitus patients before symptomatic peripheral neuropathy

Electroencephalographic Changes in Type 2 Diabetes Mellitus During Hyperventilation and Post-Hyperventilation

Brain Wave Changes during Cognitive Task Performance in Uncomplicated Diabetic Adults: An Exploratory Study

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