Which tests are most useful in distinguishing between reactive thrombocytosis and the thrombocytosis of myeloproliferative disease?

Majer, R.V.; Dawe, A.; Weir, P; Jones‐Lecointe, A.; Green, P.J.

doi:10.1111/j.1365-2257.1991.tb00246.x

Cited by 12 publications

(2 citation statements)

References 24 publications

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“…The most discriminating parameters in the present study have been fibrinogen (confirming the report of Majer et al 1991), ESR, VIIIC and vWFAg: all were raised in the reactive group and all were consistent with an acute phase response. The discriminating capacity of IL6 could similarly be associated with its known action of inducing hepatic synthesis and release of acute phase proteins.…”

Section: Primary Thrombocythaernia 147supporting

confidence: 89%

Primary thrombocythaemia: a composite approach to diagnosis

Messinezy

Westwood

Sawyer

et al. 2008

Clinical &Amp; Laboratory Haematology

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Summary. Traditional diagnostic criteria for primary thrombocythaemia (PT) remain essentially negative, aiming to exclude other myeloproliferative disorders and causes of reactive thrombocytosis (RT). It would be useful to have positive markers. We have examined several parameters to see how well they discriminate between PT and RT. Three groups of patients were studied: new, untreated PT (17), treated PT (12) and RT (17). Data consisted of: ESR, plasma fibrinogen, factor VIIIC, von Willebrand factor antigen (vWF:Ag), PDW, platelet nucleotide ratio (ATP:ADP) serum erythropoietin (Epo), ristocetin cofactor (vWF:RiCoF), multimeric structure of vWF, interleukin‐6, evidence of clinical ischaemia and erythroid colony formation. Erythroid colonies were assayed in a serum‐free system with the addition of Epo, IL3 or α‐IFN to produce a discriminant function (DF) successfully used in the diagnosis of primary polycythaemia in an earlier study. Acute phase reactants (ESR, fibrinogen, VIIIC, vWF:Ag) and IL6 were the best discriminants, while PDW and serum Epo were less so. ATP:ADP and clinical ischaemia were nondiscriminatory in this study. Reduction in vWF:RiCof and in high molecular weight multimers were clearly associated with PT. Endogenous erythroid colonies were nondiscriminatory, but half the PT group and only one patient in the RT group obtained a DF suggestive of myeloproliferative disorder. Judicious use of a battery of tests may provide support for diagnosis of PT in difficult cases.

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Section: Primary Thrombocythaernia 147supporting

confidence: 89%

Primary thrombocythaemia: a composite approach to diagnosis

Messinezy

Westwood

Sawyer

et al. 2008

Clinical &Amp; Laboratory Haematology

View full text Add to dashboard Cite

show abstract

“…Low platelet concentration, a condition known as thrombocytopenia, which is involved in numerous potential causes including decreased bone marrow platelet production, increased peripheral platelet destruction, increased splenic sequestration, and dilution [10]. Elevated platelet concentration, also called thrombocytosis, is involved in myeloproliferative diseases or reactive thrombocytosis [11]. Clinically, the platelet count has been used as a parameter that reflects the platelet concentration in vivo.…”

Section: Introductionmentioning

confidence: 99%