Association of human platelet antigen polymorphisms with platelet count and mean platelet volume

Zhou, Shihang; Liang, Xiaohua; Wang, Ni; Shao, Lin-Nan; Wang, Yu; Liu, Ming

doi:10.1080/10245332.2018.1445580

Cited by 3 publications

(3 citation statements)

References 39 publications

(46 reference statements)

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“…Some of them related to PTR. In a study by Zhou et al (25), the HPA-1, -2, -3, -4, -5 and -15 polymorphisms were all associated with the platelet count. In the study (14), all the platelet antigen polymorphisms HPA 1-17 were engaged in matching before transfusion, which significantly reduced the antibodies and prevented PTR.…”

Section: Discussionmentioning

confidence: 93%

Prevention of platelet transfusion refractoriness by platelet antigen gene matching: a systematic review and meta-analysis

Wang

Zhang

2021

Ann Palliat Med

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Section: Discussionmentioning

confidence: 93%

Prevention of platelet transfusion refractoriness by platelet antigen gene matching: a systematic review and meta-analysis

Wang

Zhang

2021

Ann Palliat Med

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“…Throughout the past decades, mean platelet volume, as a potential marker of platelet reactivity and a surrogate parameter for a broad variety of diseases, has been the subject of numerous investigations. To date, less attention has been paid to neurologic diseases in comparison to cardiovascular diseases [19], cancers [20–26], or genetic issues [27].…”

Section: Discussionmentioning

confidence: 99%

Is Migraine an MPV-Related Disease? An Observational Study of Polish Neurological Patients

Brzeźniakiewicz‐Janus

Lancé

Tukiendorf

et al. 2019

Disease Markers

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Many studies have found correlations between abnormal MPV and clinical reactivity in a variety of diseases. In the present paper, we sought MPV-related neurological diseases that are less frequently reported in the literature. The electronic medical records of 852 neurological patients with mean platelet volume (MPV) measurements (F = 45%, age = 55.7 ± 18.7, 8–104) were searched after the patients had received a diagnosis of a neurological disease (new and old episodes) according to the nine classes of the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10). A set of consecutive statistical methods (i.e., cluster analysis, segmented regression, linear correlation, propensity score matching, and mixed effects Poisson regression) were used to establish a link between MPV and neurological disease. A statistically significant (p < 0.05) relationship with MPV was found only in pain syndrome patients, with seven out of eight clinically diagnosed migraine episodes. With all other ICD-10 classes of neurological diseases, the effect of MPV was found to be nonsignificant (p > 0.05). MPV may implicate a clinical relationship with pain syndrome and migraine episodes. More complex statistics could help analyse data and find new correlations.

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“…The platelet count has been used as a platelet concentration parameter. Platelet concentration is crucial for the maintenance of hemostatic function [16]. Low platelet concentration indicating decrease in platelet count can be observed in numerous cases including increased peripheral platelet destruction, increased splenic sequestration, decreased bone marrow platelet production [17].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of mean platelet volume and platelet count in patients with schizophrenia

Aydın

İlhan

Elmas

et al. 2018

Family Practice and Palliative Care

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Introduction: Compared to the general population, cardiovascular diseases are more common in schizophrenia patients and the mortality rate is higher than the general population. One of the explanations for increased cardiovascular events in patients with schizophrenia is the increase in platelet activity. Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombus formation. Mean platelet volume (MPV) is a measure of platelet size and a good marker of platelet function and activation, which increases in cardiovascular diseases. MPV is routinely reported during complete blood count analysis. The aim of the present study was to evaluate MPV values of patients with schizophrenia. Methods: In this retrospective study, hospital-records of the patients who were consecutively admitted to psychiatry inpatient clinic between January 2015 and January 2017 with the diagnosis of schizophrenia were reviewed. Healthy subjects with no personal history of psychiatric disorder were included as a control group. Results: A total of 100 (59 female, 41 male) schizophrenic patients who had been consecutively admitted to the psychiatry inpatient clinic and 37 (20 female, 17 male) healthy controls were included in this retrospective study. There were no significant differences between the patient group and control group in the terms of age (mean age patient group vs control group: 37.72 vs 35.03, p=0.081) and sex (p=0.603). Body mass index (BMI) was found to be significantly different between groups, higher in the patient group (p=0.001). The MPV was found to be significantly higher in patient group compared with the control group (MPV, patient group vs control group: 10.34 fL vs 9.97 fL, p=0.041). Platelet count (PC) was significantly lower in the patient group (PC, patient group vs control group: 234.36 vs 267.38, p=0.008) There was no correlation between MPV and BMI (p=0.354, r=0.10), and duration of illness (p=0.530, r=0.06). Conclusions: As a result, increased MPV and decreased PC were found in a group of schizophrenic patient in this study. Since increased MPV and decreased PC are evaluated as risk factors for cardiovascular diseases in the general population, they can also be considered as a predictor of risk factors for cardiovascular diseases that are more frequently encountered in schizophrenia.

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Association of human platelet antigen polymorphisms with platelet count and mean platelet volume

Abstract: This study demonstrates that HPA-2, -5 and -15 polymorphisms are associated with the platelet count while HPA-5 polymorphism is associated with MPV. This finding will further our understanding of the association of HPA polymorphisms with platelet-related diseases.

Cited by 3 publications

References 39 publications

Prevention of platelet transfusion refractoriness by platelet antigen gene matching: a systematic review and meta-analysis

Prevention of platelet transfusion refractoriness by platelet antigen gene matching: a systematic review and meta-analysis

Is Migraine an MPV-Related Disease? An Observational Study of Polish Neurological Patients

Evaluation of mean platelet volume and platelet count in patients with schizophrenia

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