Which tinnitus-related characteristics affect current health-related quality of life and depression? A cross-sectional cohort study

Weidt, Steffi; Delsignore, Aba; Meyer, Martin; Rufer, Michael; Peter, Nicole; Drabe, Natalie; Kleinjung, Tobias

doi:10.1016/j.psychres.2016.01.065

Cited by 52 publications

(51 citation statements)

References 37 publications

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“…This finding is not unexplainable because quality of life has already been found to be associated with cognitive functions and emotional distress [24]. This interpretation is further supported by findings from the validation of the Dutch TFI, in which the subscales cognitive interference and reduced quality of life were summarized in one factor [10].…”

Section: Discussionsupporting

confidence: 66%

Tinnitus functional index: validation of the German version for Switzerland

Peter

Kleinjung

Jeker

et al. 2017

Health Qual Life Outcomes

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BackgroundDifferent standardized questionnaires are used to assess tinnitus severity, making comparisons across studies difficult. These questionnaires are also used to measure treatment-related changes in tinnitus although they were not designed for this purpose. To solve these problems, a new questionnaire - the Tinnitus Functional Index (TFI) - has been established. The TFI is highly responsive to treatment-related change and promises to be the new gold standard in tinnitus evaluation. The aim of the current study was to validate a German version of the TFI for a German-speaking population in Switzerland.MethodsAt the ENT department of the University Hospital Zurich, 264 subjects completed an online survey including the German version for Switzerland of TFI, Tinnitus Handicap Inventory (THI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and sociodemographic variables. Internal consistency of the TFI was calculated with Cronbach’s alpha coefficient. Pearson correlation coefficients were used for the test-retest reliability of the TFI and to investigate convergent and discriminant validity between the THI and the BDI and BAI, respectively. Factor analysis was assessed using a principal component analysis with oblique rotation. The different factors extracted were then compared with the original questionnaire.ResultsThe German version of the TFI for Switzerland showed an excellent internal consistency (Cronbach’s alpha of 0.97) and an excellent test-retest reliability of 0.91. The convergent validity with THI was high (r = 0.86). The discriminant validity with BAI and BDI showed moderate results (BAI: r = 0.60 and BDI: r = 0.65). In the factor analysis only five factors with one main factor could be extracted instead of eight factors as described in the original version. Nevertheless, relations to the original eight subscales could be demonstrated.ConclusionThe German version of the TFI for Switzerland is a suitable instrument for measuring the impact of tinnitus. The reliability and validity of this version are comparable with the original version of the TFI. Although this study showed only five factors in the factor analysis, relations to the original eight subscales were identified. Therefore, the German version of the TFI for Switzerland can deliver relevant information regarding the different tinnitus domains.Trial registrationClinical trial registration number on clinicaltrial.gov: NCT01837368.

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Section: Discussionsupporting

confidence: 66%

Tinnitus functional index: validation of the German version for Switzerland

Peter

Kleinjung

Jeker

et al. 2017

Health Qual Life Outcomes

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“…For this purposes we compiled a sample of TI with similar psychopathological profiles. Clinically pertinent prevalences of depressive and anxiety disorders were noted consistently in TI populations (Loprinzi et al, 2013;Zöger et al, 2001;Weidt et al, 2016). However, it should be emphasized that tinnitus-related distress must not be automatically equated with the umbrella term depression.…”

Section: The Present Studymentioning

confidence: 99%

EEG oscillatory power dissociates between distress- and depression-related psychopathology in subjective tinnitus

et al. 2017

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Recent research has used source estimation approaches to identify spatially distinct neural configurations in individuals with chronic, subjective tinnitus (TI). The results of these studies are often heterogeneous, a fact which may be partly explained by an inherent heterogeneity in the TI population and partly by the applied EEG data analysis procedure and EEG hardware. Hence this study was performed to re-enact a formerly published study (Joos et al., 2012) to better understand the reason for differences and overlap between studies from different labs. We re-investigated the relationship between neural oscillations and behavioral measurements of affective states in TI, namely depression and tinnitus-related distress by recruiting 45 TI who underwent resting-state EEG. Comprehensive psychopathological (depression and tinnitus-related distress scores) and psychometric data (including other tinnitus characteristics) were gathered. A principal component analysis (PCA) was performed to unveil independent factors that predict distinct aspects of tinnitus-related pathology. Furthermore, we correlated EEG power changes in the standard frequency bands with the behavioral scores for both the whole-brain level and, as a post hoc approach, for selected regions of interest (ROI) based on sLORETA. Behavioral data revealed significant relationships between measurements of depression and tinnitus-related distress. Notably, no significant results were observed for the depressive scores and modulations of the EEG signal. However, akin to the former study we evidenced a significant relationship between a power increase in the β-bands and tinnitus-related distress. In conclusion, it has emerged that depression and tinnitus-related distress, even though they are assumed not to be completely independent, manifest in distinct neural configurations.

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“…Thus, the authors report that tinnitus may precede depression. Along with that, the rate of tinnitus described as uncomfortable among subjects was For the evaluation of tinnitus, depression and anxiety, the most frequently mentioned instruments were, respectively: the Tinnitus Handicap Inventory (THI) 19,20,23,24,26 ; the Beck Depression Inventory (BDI) 18,19,26 ; the Patient Health Questionnaire-9 (PHQ9) 21,25,28 ; and the Generalized Anxiety Disorder 7-item (GAD-7) 21,25 .…”

Section: Mini-tq12;mentioning

confidence: 99%

Tinnitus and its relationship with anxiety and depression in the elderly: a systematic review

et al. 2019

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Objective: to verify, in the literature, a probable association of tinnitus with anxiety and depression in the elderly. Methods: a systematic review (through a search in the indexed databases - Lilacs, Scielo, Pubmed, Science Direct, The Cochrane Library) of studies published between 2013 and 2018, in Portuguese and in English, involving adults and/or elderly (18 years and older). The descriptors used were: “tinnitus", "depression", "anxiety", "adult", "elderly", interspersed by the Boolean operator AND. Results: 11 studies were selected, from which, 5 compared adults to elderly and only 2 evaluated such relationship in the elderly alone. Studies suggest that, as age increases, tinnitus severity and psychological symptoms also increase, affecting both men and women. Conclusion: few studies compared the relationship between the variables among the elderly. A probable association between the variables for both genders has been found, suggesting that the advancing age contributes to the increase of tinnitus severity and its psychological symptoms, affecting the quality of life of these individuals. Further studies are suggested to confirm the association between tinnitus, anxiety and depression in the elderly. Multi-professional work is important for the evaluation and treatment of these people.

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Which tinnitus-related characteristics affect current health-related quality of life and depression? A cross-sectional cohort study

Cited by 52 publications

References 37 publications

Tinnitus functional index: validation of the German version for Switzerland

Tinnitus functional index: validation of the German version for Switzerland

EEG oscillatory power dissociates between distress- and depression-related psychopathology in subjective tinnitus

Tinnitus and its relationship with anxiety and depression in the elderly: a systematic review

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