WHipple-ABACUS, a simple, validated risk score for 30-day mortality after pancreaticoduodenectomy developed using the ACS-NSQIP database

Gleeson, Elizabeth M.; Shaikh, Mohammad F.; Shewokis, Patricia A.; Clarke, John R.; Meyers, William C.; Pitt, Henry A.; Bowne, Wilbur B.

doi:10.1016/j.surg.2016.06.040

Cited by 62 publications

(51 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cause of death being myocardial ischemia during the postoperative period in two patients. Although this mortality rate is high when compared to literature deaths occurred in two cases who are aged above 65 years with significant cardiovascular risk factors corresponding to specific subgroups of patients with a high risk of morbidity and mortality (EM Gleeson et al 29 ).…”

Section: Complicationsmentioning

confidence: 80%

Outcome of Diseases of Pancreas in Tertiary Care Hospital

Rao¹,

Prasadula²,

Prasad³

et al. 2019

jebmh

View full text Add to dashboard Cite

BACKGROUND There has been a meteoric rise in the fraction of patients who are presenting with the disorders of the pancreas, necessitating the need for increased awareness of the disease and treatment modalities of disorders of the pancreas, the appropriate modalities for diagnosis and the proper treatment protocols that have been utilized. METHODS This study was done among 60 out of 81 patients with various pancreatic diseases who were admitted and operated in the surgery department for two years (2017-2019). RESULTS There is an increased rate of pancreatic surgeries during this period as compared to the previous two years (2015-2017) as only 42 out of 60 were operated previously. There is also increased incidence of pancreatic diseases as reflected by the total number of admissions, which increased from 60 during the period of (2015-2017) to 81 during the period of (2017-2019). This is due to the increased incidence of alcoholism, smoking, gall stone diseases reinforced by studies done by Kontis V et al, 1 Hirota et al. 2 CONCLUSIONS Most cases of benign pancreatic disorders were identified between 3rd to 5th decades and pancreatic malignancies in 5th and 6th decades. More cases of pancreatic malignancies are being identified in resectable stages.

show abstract

Section: Complicationsmentioning

confidence: 80%

Outcome of Diseases of Pancreas in Tertiary Care Hospital

Rao¹,

Prasadula²,

Prasad³

et al. 2019

jebmh

View full text Add to dashboard Cite

show abstract

“…Although this model is based on a similar data set and incorporates some of the same factors as the ACS NSQIP risk calculator, the reported c-statistic of this model is only 0.71. (14) The c-statistic of the ACS NSQIP risk calculator in all patients was reported to be 0.944 for mortality. (8) It has also been demonstrated that Whipple-specific complications, including postoperative pancreatic fistula, lead to an increase in actual length of stay beyond what the ACS NSQIP risk calculator predicts.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the American College of Surgeons National Surgical Quality Improvement project risk calculator: results from the U.S. Extrahepatic Biliary Malignancy Consortium

Beal

Lyon

Kearney

et al. 2017

HPB

View full text Add to dashboard Cite

Background The objective of this study is to evaluate use of the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) online risk calculator for estimating common outcomes after operations for gallbladder cancer and extrahepatic cholangiocarcinoma. Methods Subjects from the United States Extrahepatic Biliary Malignancy Consortium (USE-BMC) who underwent operation between January 1, 2000 and December 31, 2014 at 10 academic medical centers were included in this study. Calculator estimates of risk were compared to actual outcomes. Results The majority of patients underwent partial or major hepatectomy, Whipple procedures or extrahepatic bile duct resection. For the entire cohort, c-statistics for surgical site infection (0.635), reoperation (0.680) and readmission (0.565) were less than 0.7. The c-statistic for death was 0.740. For all outcomes the actual proportion of patients experiencing an event was much higher than the median predicted risk of that event. Similarly, the group of patients who experienced an outcome did have higher median predicted risk than those who did not. Conclusions The ACS NSQIP risk calculator is easy to use butrequires further modifications to more accurately estimate outcomes for some patient populations and operations for which validation studies show suboptimal performance.

show abstract

“…7 Patients' demographics, preexisting comorbidities, and preoperative laboratory data were attributable to the development of severe complications after PD. 7,8 Early postoperative serum C-reactive protein (CRP) levels were also useful as early diagnostic markers for the aggravation of postoperative complications. 9,10 However, postoperative complications associated with infection are often difficult to distinguish from surgical stress-induced inflammatory responses, especially at the early postoperative period.…”

Section: Introductionmentioning

confidence: 99%

Serum procalcitonin as an early diagnostic marker of severe postoperative complications after elective pancreaticoduodenectomy

Hata

Mizuma

Motoi

et al. 2020

J Hepato Biliary Pancreat

View full text Add to dashboard Cite

Background/Purpose: To evaluate the clinical utility of serum procalcitonin (PCT) as a diagnostic marker for the severe postoperative complications associated with pancreaticoduodenectomy (PD). Methods: A total of 387 patients were enrolled and the PCT and C-reactive protein (CRP) values were compared between the non-severe complications group (Clavien-Dindo classification Grade IIIb and lower) and severe complications (Grade IVa and higher). Results: Severe complications occurred in 16 patients. In the severe complications group, CRP levels peaked on postoperative day (POD) 3, whereas PCT levels peaked on POD 1. The PCT levels on PODs 1-5 were significantly higher in the severe complications group. Regarding the diagnostic performance, the PCT value on POD 2 higher than 2.1 ng/mL revealed the highest performance, with 66.7% sensitivity and 78.6% specificity. Based on the postoperative kinetics and multivariate analysis, PCT and CRP both act independently of each other and the combination assay improved the diagnostic power (area under the curve 0.781; sensitivity 60.0%; specificity 85.6%). Preoperative biliary drainage was found to affect the perioperative PCT values and subgroup analysis stratified by the drainage procedure improved diagnostic sensitivity (~85%). Conclusions: Procalcitonin in the early postoperative period can serve as an earlier detector for the development of severe complications after PD.

show abstract

WHipple-ABACUS, a simple, validated risk score for 30-day mortality after pancreaticoduodenectomy developed using the ACS-NSQIP database

Cited by 62 publications

References 22 publications

Outcome of Diseases of Pancreas in Tertiary Care Hospital

Outcome of Diseases of Pancreas in Tertiary Care Hospital

Evaluating the American College of Surgeons National Surgical Quality Improvement project risk calculator: results from the U.S. Extrahepatic Biliary Malignancy Consortium

Serum procalcitonin as an early diagnostic marker of severe postoperative complications after elective pancreaticoduodenectomy

Contact Info

Product

Resources

About