Whispering gallery mode resonators in continuous flow: spectral assignments and sensing with monodisperse microspheres

Paulus, Bryan C.; Banh, Jenny K.; Rector, Kirk D.; Stein, Benjamin W.; Lilley, Laura M.

doi:10.1039/d2ay00181k

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…More operational details are available in video S3 and video S4. These two situations could both find useful applications in practical applications, for example, to eliminate undesired target (by strong ballistic shooting) or to install tiny mechanical payload for sensing [41] or deliver medicine or genetic cues [15,42]. To further exemplify this functionality, a simple bio-target shooting was carried out, where a sideflipped algal cell (15 μm wide and 20 μm long) was selected as the target, sitting 55 μm away from the slingshot.…”

Section: Directional Shooting Operationmentioning

confidence: 99%

Single-nanowire-morphed mechanical slingshot for directional shooting delivery of micro-payloads

Zhang

Jiang

et al. 2023

Nanotechnology

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Stretching elastomer bands to accumulate strain energy, for a sudden projectile launching, has been an old hunting skill that will continue to find new applications in miniaturized worlds. In this work, we explore the use of highly resilient and geometry-tailored ultrathin crystalline silicon nanowires (SiNWs) as elastic medium to fabricate the first, and the smallest, mechanical slingshot. These NW-morphed slingshots were first grown on planar surface, with desired layout, and then mounted upon standing pillar frames, with a unique self-hooking structure that allows for a facile and reliable assembly, loading and shooting maneuvers of microsphere payloads. Impressively, the elastic spring design can help to store 10 times more strain energy into the NW springs, compared to the straight ones under the same pulling force, which has been stronger enough to overcome the sticky van de Waals (vdW) force at the touching interfaces that otherwise will hinder a reliable releasing onto soft surface with low-surface energy or adhesion force, and to achieve a directional shooting delivery of precise amount of tiny payload units onto delicate target with the least impact damage. This NW-morphing construction strategy provides also a generic protocol/platform to fast design, prototype and deploy new nanoelectromechanical and biological applications at extremely low costs.

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Section: Directional Shooting Operationmentioning

confidence: 99%

Single-nanowire-morphed mechanical slingshot for directional shooting delivery of micro-payloads

Zhang

Jiang

et al. 2023

Nanotechnology

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show abstract

“…Different reagents can be pumped through to study the interaction between antibodies and proteins expressed by cancer cells. Lilley et al recently reported a continuous flow technique for measuring active dye-doped WGM microspheres suspended in solution, and a clustering algorithm was developed to analyze the results and differentiate signals from two different sizes of microspheres . In both cases, an external pump was required for operation, which is not ideal for POC or remote sensing.…”

Section: Introductionmentioning

confidence: 99%

Microsphere-Enabled Micropillar Array for Whispering Gallery Mode Virus Detection

Guan,

Kok,

Riesen

et al. 2024

ACS Appl. Mater. Interfaces

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Rapid detection of pathogens and analytes at the point of care offers an opportunity for prompt patient management and public health control. This paper reports an open microfluidic platform coupled with active whispering gallery mode (WGM) microsphere resonators for the rapid detection of influenza viruses. The WGM microsphere resonators, precoated with influenza A polyclonal antibodies, are mechanically trapped in the open micropillar array, where the evaporation-driven flow continuously transports a small volume (∼μL) of sample to the resonators without auxiliaries. Selective chemical modification of the pillar array changes surface wettability and flow pattern, which enhances the detection sensitivity of the WGM resonatorbased virus sensor. The optofluidic sensing platform is able to specifically detect influenza A viruses within 15 min using a few microliters of sample and displays a linear response to different virus concentrations.

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A Pump-Free Optofluidic Biosensing Platform Based on Whispering Gallery Mode Microspheres

Guan,

Kok,

Riesen

et al. 2023

2023 Ieee Sensors

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Whispering gallery mode resonators in continuous flow: spectral assignments and sensing with monodisperse microspheres

Abstract: Whispering gallery mode resonator (WGMR) microspheres yield highly structured optical spectra that are extremely sensitive to their environment and are of intense interest for use in a variety of sensing...

Cited by 3 publications

References 35 publications

Single-nanowire-morphed mechanical slingshot for directional shooting delivery of micro-payloads

Single-nanowire-morphed mechanical slingshot for directional shooting delivery of micro-payloads

Microsphere-Enabled Micropillar Array for Whispering Gallery Mode Virus Detection

A Pump-Free Optofluidic Biosensing Platform Based on Whispering Gallery Mode Microspheres

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