White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study

Ishida, Shigeru; Kondo, Seiji; Satoh, Atsushi; Maeda, Toshiki; Kawazoe, Miki; Yoshimura, Chikara; Tada, Kazuhiro; Takahashi, Koji; Ito, Kenji; Yasuno, Tetsuhiko; Masutani, Kosuke; Nakashima, Hitoshi; Arima, Hisatomi

doi:10.1371/journal.pone.0246304

Cited by 24 publications

(17 citation statements)

References 20 publications

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“…This study was a population‐based retrospective cohort study of the residents of Iki City, Nagasaki Prefecture, Japan, and used data from the Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA‐CKD) study, which has been described in detail previously. 10 , 11 , 12 , 13 , 14 , 15 Iki City is located in the north of Nagasaki Prefecture and has a population of approximately 27 000. We enrolled 7895 participants aged ≥30 years who underwent annual health check‐ups conducted by the local government of Iki City between 2008 and 2017.…”

Section: Methodsmentioning

confidence: 99%

Effect of chronic kidney disease on the association between hyperuricemia and new‐onset hypertension in the general Japanese population: ISSA‐CKD study

Kawazoe

Ishida

Yoshimura

et al. 2021

J of Clinical Hypertension

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We aimed to investigate the association between serum uric acid (SUA) level and development of hypertension as well as the interaction effect of chronic kidney disease (CKD) on this relationship in the general Japanese population. We included 7895 participants aged ≥30 years from the ISSA‐CKD study, a population‐based retrospective cohort study that used annual health check‐up data of residents from Iki Island, Japan. After the exclusion of 1881 with l < 1‐year follow‐up, 2812 with hypertension at baseline, and 165 with missing information on SUA, a total of 3037 participants were enrolled in this analysis. Participants were divided into four groups according to the quartiles of SUA level at baseline, and multivariable‐adjusted hazard ratios for new‐onset hypertension were calculated. Stratified analyses were performed for each subgroup (defined by sex, age, alcohol intake, and CKD) to assess the interaction effects. During a mean follow‐up period of 4.4 years, 943 participants developed hypertension. The first quartile group was set as the reference group, and the multivariable‐adjusted hazard ratios (95% confidence interval) for new‐onset hypertension were 1.11 (0.90–1.36) in the second quartile, 1.25 (1.02–1.54) in the third quartile, and 1.35 (1.07–1.70) in the fourth quartile compared with those in the reference group ( p = .007 for trend). The stratified analyses showed that the association between SUA and hypertension was significantly stronger in participants with CKD than in those without CKD ( p = .035 for interaction). SUA level is an independent risk factor for new‐onset hypertension. This tendency was significantly stronger in participants with CKD.

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Section: Methodsmentioning

confidence: 99%

Effect of chronic kidney disease on the association between hyperuricemia and new‐onset hypertension in the general Japanese population: ISSA‐CKD study

Kawazoe

Ishida

Yoshimura

et al. 2021

J of Clinical Hypertension

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“…White blood cells (WBCs) are a well‐known biomarker of systemic inflammation. The WBC count has been reported to be associated with chronic diseases, including cancer, type 2 diabetes, hypertension, and obesity 1–6 ; our previous study also found a link between WBC count alteration and type 2 diabetes risk 7 . In addition, various studies have demonstrated that the WBC count is a valuable predictor of all‐cause mortality, especially in elderly individuals 8–10 .…”

Section: Introductionmentioning

confidence: 65%

Association of the MACROD2 rs6110695 A>G polymorphism with an increasing WBC count in a Korean population

Yang

Han

Lee

et al. 2022

Immunity Inflam & Disease

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Introduction We aimed to find a novel candidate gene related to the white blood cell (WBC) count in a Korean population. Since WBC count has been reported to have a relation to the risk of chronic diseases according to previous literature, WBC level prediction can be helpful for managing future risk of chronic disease development. In this aspect, a gene newly found in the present study is expected to be utilized as a tool for judging an individual's WBC level. Methods Based on the 153 study participants' genotype data produced by the Korean Chip. The mono‐adenosine diphosphate ribosylhydrolase 2 (MACROD2) rs6110695 A>G polymorphism had a significant strong association with WBC count, thus, the MACROD2 gene emerged as a novel candidate gene for WBC count. To verify the effects of the single‐nucleotide polymorphisms on WBC count, the participants were grouped according to the rs6110695 AA and AG genotypes. Results WBC to apolipoprotein A‐I ratio, WBC count, granulocyte to lymphocyte ratio, monocyte to platelet ratio, and interferon‐γ level were significantly higher in the AG genotype group than in the AA genotype group. Through the receiver operating characteristic curve analysis, the rs6110695 AA and AG genotypes were discriminated by the optimal WBC count cutoff value of 5.450. As expected, the results in the participants having a WBC count over 5.450 were similar to the AG genotype group. Conclusions We revealed that the MACROD2 rs6110695 AG genotype has an association with increasing WBC count. Since, as previous literature described, WBC count is one of the main risk factors for chronic diseases, WBC count measurement in individuals with the rs6110695 AG genotype that was found in the present study may help manage future chronic disease risk.

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“…32 However, previous studies suggested that the relationship between WBC count and HT was affected by ethnicity and sex. 15,17,34,43 The NHANES I Epidemiologic Follow-up Study reported an association between a higher WBC count and an increased incidence of HT in white men, and possibly older white and black women, but no positive association was found in black men. 43 A predominantly white cohort study conducted in Wisconsin reported that an elevated WBC count was associated with incident HT among women and men independent of smoking and most traditional cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…17 In addition, an observational study of a general Japanese population showed a close association between WBC count and further development of HT. 15 Regarding the subtypes of WBCs, high levels of neutrophils 44 and monocytes, 45 and low lymphocytes 46 have been proposed as potential predictors of CVD. The neutrophil count was demonstrated to be the strongest component of the WBC associated with SBP and DBP in an observational analysis of the UK Biobank, but there was no evidence of a causal effect in Mendelian randomization analysis.…”

Section: Discussionmentioning

confidence: 99%

Components of the Complete Blood Count as a Risk Predictor for Incident Hypertension in a Large Taiwanese Population Follow-up Study

Liu

Chen

Lee

et al. 2023

Circ J

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CVD and death. 6,7 However, nearly all elements of the complete blood count (CBC), including WBCs, red blood cells (RBCs), and platelets, are also involved in the underlying pathogenesis of atherosclerosis. 8-10 The relationship between arterial calcification and RBCs is bidirectional: calcification promotes hemorrhage, and hemoglobin (Hb) release promotes calcification of elastic vascular tissues. 9Local RBC hemolysis has also been associated with both early and advanced stages of atherosclerosis. 9 In addition to their known functions in thrombosis and hemostasis, platelets provide a link among inflammation, thrombosis, and atherosclerosis. 10 In atherosclerosis, platelets promote the recruitment of inflammatory cells to the lesion site and release large amounts of inflammatory mediators by interacting with endothelial cells and circulating leukocytes. 10 Various elements of the CBC have been associated with H ypertension (HT) is one of the most common diseases and an important cause of cardiovascular disease (CVD) and death in developed countries. 1,2 It causes cardiac hypertrophy, which leads to cardiomyopathy and heart failure, as well as serious blood vessel-related complications, such as stroke, coronary artery disease, aortic aneurysm, aortic vascular dissection, and renal vascular disease, all of which can result in permanent damage and death. 3 The prevalence of HT among adults aged ≥18 years in Taiwan is approximately 25%, and the rate continues to increase. 4 HT is a multifactorial disease, and inflammation is known to play an important role in the development of both atherosclerosis and HT. 5 An elevated circulating white blood cell (WBC) count, a well-known independent marker of systemic inflammation, has been associated with

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White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study

Cited by 24 publications

References 20 publications

Effect of chronic kidney disease on the association between hyperuricemia and new‐onset hypertension in the general Japanese population: ISSA‐CKD study

Effect of chronic kidney disease on the association between hyperuricemia and new‐onset hypertension in the general Japanese population: ISSA‐CKD study

Association of the MACROD2 rs6110695 A>G polymorphism with an increasing WBC count in a Korean population

Components of the Complete Blood Count as a Risk Predictor for Incident Hypertension in a Large Taiwanese Population Follow-up Study

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