White Blood Cell, Hemoglobin and Platelet Distribution Width as Short-Term Prognostic Markers in Patients with Acute Myocardial Infarction

Abstract

The aim of this study was to assess the prognostic value of combined use of white blood cell (WBC), hemoglobin (Hb), and platelet distribution width (PDW) in patients with acute myocardial infarction (AMI). This study included 1,332 consecutive patients with AMI. Patients were categorized into complete blood cell (CBC) group 0 (n=346, 26.0%), 1 (n=622, 46.7%), 2 (n=324, 24.3%), and 3 (n=40, 3.0%) according to the sum of the value defined by the cut-off levels of WBC (1, ≥14.5×103/µL; 0, <14.5×103/µL), Hb (1, <12.7 g/dL; 0, ≥12.7 g/dL), and PDW (1, ≥51.2%; 0: <51.2%). In-hospital death occurred in 59 (4.4%) patients. Patients who died during index hospitalization had higher WBC and PDW and lower Hb. The patients could be stratified for in-hospital mortality according to CBC group; 1.2%, 2.7%, 9.0%, and 22.5% in CBC groups 0, 1, 2, and 3 (P<0.001), respectively. In multivariate logistic regression analysis, CBC group≥2 (odds ratio, 3.604; 95% confidence interval, 1.040-14.484, P=0.043) was an independent predictor for in-hospital death. The prognostic impact of the combined use of CBC markers remained significant over 12 months. In conclusions, combination of WBC, Hb, and PDW, a cheap and simple hematologic marker, is useful in early risk stratification of patients with AMI.

Prognostic Factors for In-Hospital and Long-Term Survival in Patients with Acute ST-Segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention

“…Another previous study suggested that an elevated white cell count in patients with STEMI is related to the body's stress response and changes due to coronary endothelial dysfunction. This up-regulates the production of inflammatory cells and cytokines, promotes rupture of atherosclerotic plaque(s) and capillary congestion, and induces and aggravates acute coronary disease (Bae et al 2014). …”

Хемилюминесцентная Активность Нейтрофилов У Больных Ишемической Болезнью Сердца С Разной Чувствительностью К Ацетилсалициловой Кислоте

“…Несмотря на успехи в лечении ишемической болезни сердца (ИБС), данное заболевание и сегодня занимает первое место среди причин смертности в мире. Атеросклероз и атеротромбоз являются результатом хронического воспалительного процесса [1,2]. Изменения в гемостазе и активация воспалительных процессов тесно ассоциированы между собой.…”

DEPENDENCE OF THROMBOCYTES METABOLISM FROM THE CHEMILUMINESCENT ACTIVITY OF NEUTROPHILES IN PATIENTS WITH DIFFERENT SENSITIVITY TO ACETYLSALICYLIC ACID IN ACUTE CORONARY SYNDROME Pages: 59-66

“…В настоящее время хорошо известно, что атеротромбоз -это результат хронического воспали-тельного процесса в атеромах при атеросклерозе [1]. Из-менения в гемостазе и активация воспалительных про-цессов тесно ассоциированы между собой, вследствие чего тромбоцитарно-лейкоцитарное взаимодействие становится ведущим в патогенезе ОКС.…”