On June 16, 2015, Donald J. Trump announced his candidacy for president of the United States, stating that he would build a wall on the southern border and Mexico would pay for it. From that moment on, the U.S.-Mexico border region became the news epicenter in the nation throughout the 2016 presidential campaign. This article examines Trump’s candidate-generated messages in relation to the border as part of his political communication strategy. The authors perform a content analysis of his political ads and his Twitter posts along with a textual analysis of his official website and his first 100 day contract. The Spearman’s rank-order correlation coefficient was then used to assess the degree of interdependence of issue positions for each issue. Outcomes showed that Trump presented 16 issues, six related to the border (the economy, foreign policy, immigration, regulations, taxes, and trade). Results found 28 issue positions relating to the border, with the highest number of solutions offered via Trump’s Twitter agenda and his 100 day agenda. The strongest degree of interdependence between agendas was observed on immigration between Trump’s TV-ad agenda and his 100 day agenda (rho = +0.545), and on the economy between Trump’s TV-ad agenda and his Twitter agenda (rho = +0.538). In both instances, the messages transmitted to voters on those political communication venues were very similar to each other.