Squamous cell carcinoma (SCC) is the most frequent malignant neoplasm affecti ng structures of the oral mucosa, which accounts for more than 90% of all malignant lesions in the mouth. The aim of this study was to report a case of well differentiated squamous cell carcinoma of gingiva. A 50 year old female seen with 3 weeks history of a painless mass over the lower left posterior buccal gingival area. Clinical examination revealed, a reddish white, ulcerative spongy asymptomatic lesion around the buccal area of teeth 33 to 37 and a leukoplakic lesion over the left border of the tongue & whole of poste rior left buccal mucosa. Thus, in view of the clinical symptoms and differential diagnosis of a malignant neoplasm, an incisional biopsy was obtained from the lesion. The diagnosis of well differentiated squamous cell carcinoma was made and fourteen days after incisional biopsy, healing was found to be unsatisfactory. The patient was referred for treatment consisting of surgical excision of the tumour.