Background: As the share of the older population is growing worldwide, health systems in developing countries need a policy shift to address the challenge of the optimization of healthcare across age groups. Many older people in resource-limited countries will seek specific care due to multimorbidity and frailty, as the burden of non-communicable diseases is getting heavier. Methods: Over a one-year period, we trained healthcare workers and developed new procedures of care in the geriatric unit of the Yaoundé Central Hospital in Cameroon, using the Acute Care for Elders (ACE) model. This model of care in Geriatrics is based on a patient-centered approach and is focused on preventing functional decline in acutely ill older patients. Results: During the implementation of the ACE model, 202 patients were hospitalized in the unit, of whom 60.9% (n=123) were female; the mean (SD) age was 79.3 (8.8) years. A multidisciplinary team was brought together, including a geriatrician, two general practitioners, two geriatric nurses, two advanced practice nurses and a social worker. After a thorough examination of the care procedures, nurses were given complementary missions, such as assessing functional status and providing therapeutic education to the patients and their family members. All hospitalized and ambulatory patients were offered a comprehensive geriatric assessment at the outpatient clinic.Conclusion: It was possible to establish a comprehensive model of care for older patients in our hospital with few trained personnel. Further actions are needed to improve the care of older people in resource-limited settings.